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预防医学  2021, Vol. 33 Issue (11): 1117-1121    DOI: 10.19485/j.cnki.issn2096-5087.2021.11.009
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大肠埃希菌O157:H7抗生素耐药性研究进展
卢丽英 综述, 詹丽杏 审校
中国科学院上海营养与健康研究所,上海 200030
Research progress on antibiotic resistance of Escherichia coli O157:H7
LU Liying, ZHAN Lixing
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200030, China
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摘要 病原微生物污染是食源性疾病发生的主要原因。血清型O157:H7是目前全球报道最多、引起疾病最严重的大肠埃希菌(E.coli)之一。临床上尚未发现有效方案治疗其引起的感染。抗生素治疗E.coli O157:H7早期感染具有一定效果,但近年来抗生素的广泛使用导致了耐药菌的产生和耐药基因的传播,已成为公共健康的巨大威胁。本文对E.coli O157:H7抗生素耐药菌的流行、耐药机制及防控措施的研究进展进行综述,为E.coli O157:H7感染的预防、早期临床用药及相关研究提供参考。
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卢丽英
詹丽杏
关键词 大肠埃希菌O157:H7抗生素耐药性耐药基因食源性疾病    
Abstract:Contamination of foodborne pathogens is the main cause of related diseases. Escherichia coli O157:H7 (E.coli O157:H7), as a representative of pathogenic E.coli, is one of the most severe and commonly reported E.coli in the world, but there is still no effective clinical treatment against the infection. Antibiotics show effective in the early infection of E.coli O157:H7. However, their extensive use has led to drug-resistant bacteria and genes in recent years, which becomes a great threat to public health. This article reviews the research progress of E.coli O157:H7 from the prevalence of antibiotic-resistant bacteria, the resistance mechanism, and the prevention and control methods, in order to provide a reference for its prevention, early clinical treatment and related research.
Key wordsEscherichia coli O157:H7    antibiotic resistance    resistance gene    foodborne diseases
收稿日期: 2021-05-20      修回日期: 2021-06-30      出版日期: 2021-11-10
中图分类号:  R378.21  
基金资助:科技部重点研发计划专项项目(2017YFC1600100); 国家自然科学基金面上项目(81872369)
通信作者: 詹丽杏,E-mail:lxzhan@sibs.ac.cn   
作者简介: 卢丽英,博士在读
引用本文:   
卢丽英, 詹丽杏. 大肠埃希菌O157:H7抗生素耐药性研究进展[J]. 预防医学, 2021, 33(11): 1117-1121.
LU Liying, ZHAN Lixing. Research progress on antibiotic resistance of Escherichia coli O157:H7. Preventive Medicine, 2021, 33(11): 1117-1121.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2021.11.009      或      http://www.zjyfyxzz.com/CN/Y2021/V33/I11/1117
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