Objective To evaluate the safety of two types of enterovirus 71（EV71）inactivated vaccine（Vero cell vs. Human Diploid cell）after inoculation.Methods Subjects were children vaccinated EV71 vaccine between November 2016 and May 2017 at vaccination clinics in Xiacheng District. According to the type of EV71 vaccine，subjects were divided into the Vero Cell group and the Human Diploid Cell group. The adverse effects were collected after 30 min，3 days and 30 days of injection，respectively.Results A total of 3 158 vaccinated children were observed，with 1 529 in Vero Cell group and 1 629 in Human Diploid Cell group. The rates of adverse effects were 0.59%（9 cases）of Vero cell group and 0.55 %（9cases）of Human Diploid Cell group. All of the adverse effects were systemic reactions such as fever，diarrhea and vomiting. No significant differences were observed between the two groups above in the incidence and severity of adverse effects（ P>0.05）. The incidence and severity of adverse effects of the first dose were significantly higher than the second dose in two groups（P<0.05）.Conclusion EV71 vaccine was safe to vaccinate，and no statistical difference in the adverse effects was found between the two types of vaccine.

Since coronavirus disease 2019 (COVID-19) broke out, the world has accelerated the development of preventive vaccines. By December 2020, 60 candidate vaccines have been approved for clinical trials, of which 7 vaccines, including 3 inactivated vaccines, 2 mRNA vaccines and 2 vector vaccines, have been authorized for emergency use or conditional marketing. In this paper, we reviewed the development progress in inactivated vaccines, nucleic acid vaccines, vector vaccines, protein subunit vaccines, attenuated vaccines and virus-like particle vaccines, as well as advantages and disadvantages of these vaccines. The studies showed that the vaccines against COVID-19 in phase III clinical trials had good safety and immunogenicity, and those authorized vaccines were declared to have good efficacy. However, attention should be paid to the adverse reactions of the vaccines and the long-term protective effects, in order to improve the immunization strategy for the control of COVID-19 epidemic.

Objective To investigate the occupational hazards in automobile maintenance industry in Hangzhou and to provide field-research based evidence for prevention and control. Methods We visited 12 workshops of automobile maintenance to investigate the actors of occupational hazards,examine the protective facilities,and evaluate the occupation-related risk using MES method. Results The factors of occupation-related hazards at polishing posts met the criteria. At the painting posts in the painting room,the factors of chemical hazards satisfied the criteria,however,the levels of xylene and butyl acetate exceeded the standard lines in some enterprises when the ventilation system was close. The noise was higher than the limit at a few posts of sheet metal. The ventilation in spray paint room and the dust collector in dry mill room work well. The risks of occupational hazards at grinding,painting,and sheet metal posts were slightly harmful. Conclusion The occupational hazard factors in automobile repair enterprises were much more complicated. The noise hazard of the sheet metal posts was relatively prominent.

The second batch of provincial standard revision projects in 2016 were established by Quality and Technical Supervision Institute of Zhejiang Province. The Health Standard for Disinfection in Nurseries（DB33/T 2082-2017）was jointly formulated by Zhejiang Provincial Center for Disease Control and Prevention（CDC）,Hangzhou CDC,Ningbo CDC and Zhejiang Sterilization Product Standardization Committee. The standard was recommended by the Health Committee of Zhejiang and was formally implemented on January 26,2018 with the approval of Quality and Technical Supervision Institute of Zhejiang Province. For preventing and controlling communicable diseases in kindergartens,hygiene and evaluation requirements were put forward; regulations of system management,personnel responsibilities,layout of buildings,drinking water management,air quality management,daily cleaning and disinfection requirements,disinfection methods during the onset of diseases were formulated; the sampling and testing methods for hygiene assessment were determined. This paper explained the significance and some key contents of the standard for promoting the publicity and implementation.