Research progress on the epidemiology of human adenovirus infections
XIE Jiamin1,2, WU Jie1,2
1. School of Public Health, Southern Medical University, Guangzhou, Guangdong 510515, China; 2. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong 511430, China
Abstract:Human adenovirus (HAdV), which is characterized by infectivity, complex pathogenesis and multiple target organs, causes multiple organ infections in the respiratory system, gastrointestinal system and eyes, which seriously endangers human health. Various subspecies of HAdV has different tissue tropism, which presents diverse clinical symptoms and epidemiological characteristics. Based on the molecule biological characteristics of HAdV, this review summarizes the clinical symptoms and epidemiological characteristics of HAdV infections depending on tissue tropism, and describes the trends in HAdV epidemiology, so as to provide insights into prevention and control of HAdV infections.
谢家敏, 武婕. 人腺病毒感染的流行病学研究进展[J]. 预防医学, 2023, 35(1): 32-35,40.
XIE Jiamin, WU Jie. Research progress on the epidemiology of human adenovirus infections. Preventive Medicine, 2023, 35(1): 32-35,40.
[1] ROWE W P,HUEBNER R J,GILMORE L K,et al.Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture[J].Proc Soc Exp Biol Med,1953,84(3):570-573. [2] HILLEMAN M R,WERNER J H.Recovery of new agent from patients with acute respiratory illness[J].Proc Soc Exp Biol Med,1954,85(1):183-188. [3] ZHAORI G.Severe acute hepatitis of unknown causes in children:current findings,questions,opinions,and recommendations,a mini-review[J].Pediatr Investig,2022,6(3):211-218. [4] HAQUE E,BANIK U,MONOWAR T,et al.Worldwide increased prevalence of human adenovirus type 3(HAdV-3)respiratory infections is well correlated with heterogeneous hypervariable regions(HVRs)of hexon[J/OL].PLoS One,2018,13(4)[2022-11-04].https://doi.org/10.1371/journal.pone.0194516. [5] KULANAYAKE S,TIKOO S K.Adenovirus core proteins:structure and function[J/OL].Viruses,2021,13(3)[2022-11-04].https://doi.org/10.3390/v13030388. [6] GALLARDO J,PÉREZ-ILLANA M,MARTÍN-GONZÁLEZ N,et al.Adenovirus structure:what is new?[J/OL].Int J Mol Sci,2021,22(10)[2022-11-04].https://doi.org/10.3390/ijms22105240. [7] STASIAK A C,STEHLE T.Human adenovirus binding to host cell receptors:a structural view[J].Med Microbiol Immunol,2020,209(3):325-333. [8] MARTTILA M,PERSSON D,GUSTAFSSON D,et al.CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7[J].J Virol,2005,79(22):14429-14436. [9] LENMAN A,LIACI A M,LIU Y,et al.Polysialic acid is a cellular receptor for human adenovirus 52[J].Proc Natl Acad Sci U S A,2018,115(18):E4264-E4273. [10] NEMEROW G R,STEWART P L.Insights into adenovirus uncoating from interactions with integrins and mediators of host immunity[J/OL].Viruses,2016,8(12)[2022-11-04].https://doi.org/10.3390/v8120337. [11] PROBST V,DATYNER E K,HADDADIN Z,et al.Human adenovirus species in children with acute respiratory illnesses[J].J Clin Virol,2021,134[2022-11-04].https://doi.org/10.1016/j.jcv.2020.104716. [12] HIROI S,IZUMI M,TAKAHASHI K,et al.Isolation and characterization of a novel recombinant human adenovirus species D[J].J Med Microbiol,2012,61(Part 8):1097-1102. [13] PERIN J,MULICK A,YEUNG D,et al.Global,regional,and national causes of under-5 mortality in 2000-19:an updated systematic analysis with implications for the Sustainable Development Goals[J].Lancet Child Adolesc Health,2022,6(2):106-115. [14] 人腺病毒呼吸道感染预防控制技术指南编写审定专家组.人腺病毒呼吸道感染预防控制技术指南(2019年版)[J].中华预防医学杂志,2019,53(11):1088-1093. [15] 王方明,杨传宇,钱渊,等.北京地区急性呼吸道感染住院患儿腺病毒感染临床特征[J].中华儿科杂志,2022,60(1):30-35. [16] WO Y,LU Q B,HUANG D D,et al.Epidemical features of HAdV-3 and HAdV-7 in pediatric pneumonia in Chongqing,China[J].Arch Virol,2015,160(3):633-638. [17] XIE L,ZHANG B,XIAO N,et al.Epidemiology of human adenovirus infection in children hospitalized with lower respiratory tract infections in Hunan,China[J].J Med Virol,2019,91(3):392-400. [18] 杨林飞,刘琼.36 616例呼吸道感染患者腺病毒核酸检测结果分析[J] .湖南师范大学学报(医学版),2020,17(6):14-17. [19] 陈红卫,陆小霞,李颖,等.2019年武汉儿童医院15 636例呼吸道感染儿童7项病毒检测结果分析[J].疾病监测,2022,37(1):67-71. [20] KO J H,WOO H T,OH H S,et al.Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military,2013 to 2018[J].Korean J Intern Med,2021,36(1):205-213. [21] BAUTISTA-GOGEL J,MADSEN C M,LU X,et al.Outbreak of respiratory illness associated with human adenovirus type 7 among persons attending officer candidates school,Quantico,Virginia,2017[J].J Infect Dis,2020,221(5):697-700. [22] KENMOE S,TCHENDJOU P,VERNET M A,et al.Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon,2011-2013[J].Influenza Other Respir Viruses,2016,10(5):386-393. [23] TEMPIA S,MOYES J,COHEN A L,et al.The national burden of influenza-like illness and severe respiratory illness overall and associated with nine respiratory viruses in South Africa,2013-2015[J].Influenza Other Respir Viruses,2022,16(3):438-451. [24] WANG C,LIU J,MI Y,et al.Clinical features and epidemiological analysis of respiratory human adenovirus infection in hospitalized children:a cross-sectional study in Zhejiang[J/OL].Virol J,2021,18(1)[2022-11-04].https://doi.org/10.1186/s12985-021-01705-x. [25] PAPANICOLAOU G A,DVORAK C C,DADWAL S,et al.Practice patterns and incidence of adenovirus infection in allogeneic hematopoietic cell transplant recipients:multicenter survey of transplant centers in the United States[J/OL].Transpl Infect Dis,2020,22(4)[2022-11-04].http://doi.org/10.1111/tid.13283. [26] ZHAO M C,GUO Y H,QIU F Z,et al.Molecular and clinical characterization of human adenovirus associated with acute respiratory tract infection in hospitalized children[J/OL].J Clin Virol,2020,123[2022-11-04].http://doi.org/10.1016/j.jcv.2019.104254. [27] KIM J M,JUNG H D,CHEONG H M,et al.Nation wide surveillance of human acute respiratory virus infections between 2013 and 2015 in Korea[J].J Med Virol,2018,90(7):1177-1183. [28] CHEHADEH W,AL-ADWANI A,JOHN S E,et al.Adenovirus types associated with severe respiratory diseases:a retrospective 4-year study in Kuwait[J].J Med Virol,2018,90(6):1033-1039. [29] 黄亮,吴瑕,蒋辉英.腹泻患儿腺病毒感染临床特征及流行病学分析[J].中国中西医结合儿科学,2016,8(3):348-350. [30] 任敏,谢晓丽,周更生,等.成都市2006—2008年儿童医院婴幼儿腹泻腺病毒感染的调查[J].现代预防医学,2011,38(1):37-38. [31] 马小珍,曹冉冉,任敏.2014—2020年成都市某哨点医院5岁以下腹泻患儿腺病毒分子流行病学特征[J].中国病毒病杂志,2021,11(5):358-362. [32] HUANG D,WANG Z,ZHANG G,et al.Molecular and epidemiological characterization of human adenoviruses infection among children with acute diarrhea in Shandong Province,China[J/OL].Virol J,2021,18(1)[2022-11-04].http://doi.org/10.1186/s12985-021-01666-1. [33] LEE B,DAMON C F,PLATTS-MILLS J A.Pediatric acute gastroenteritis associated with adenovirus 40/41 in low-income and middle-income countries[J].Curr Opin Infect Dis,2020,33(5):398-403. [34] QIU F Z,SHEN X X,LI G X,et al.Adenovirus associated with acute diarrhea:a case-control study[J/OL].BMC Infect Dis,2018,18(1)[2022-11-04].http://doi.org/10.1186/s12879-018-3340-1. [35] UEMURA T,MIGITA H,UENO T,et al.Clinical and virological analysis of epidemic keratoconjunctivitis caused by adenovirus type 54 in a regional ophthalmic clinic in Kyushu,Japan[J].Clin Ophthalmol,2018,12:511-517. [36] OYONG K,KILLERBY M,PAN C Y,et al.Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type D53 in an eye care clinic - Los Angeles County,2017[J].MMWR,2018,67(48):1347-1349. [37] JONAS R A,UNG L,RAJAIYA J,et al.Mystery eye:human adenovirus and the enigma of epidemic keratoconjunctivitis[J/OL].Prog Retin Eye Res,2020,76[2022-11-04].http://doi.org/10.1016/j.preteyeres.2019.100826. [38] LI D,ZHOU J N,LI H,et al.An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school,southwest China[J/OL].BMC Infect Dis,2019,19(1)[2022-11-04].http://doi.org/10.1186/s12879-019-4232-8. [39] LEI Z,ZHU Z,WANG B M C,et al.Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016[J/OL].PLoS One,2017,12(9)[2022-11-04].http://doi.org/10.1371/journal.pone.0185048. [40] RONAN B A,AGRWAL N,CAREY E J,et al.Fulminant hepatitis due to human adenovirus[J].Infection,2014,42(1):105-111. [41] GU J,SU Q Q,ZUO T T,et al.Adenovirus diseases:a systematic review and meta-analysis of 228 case reports[J].Infection,2021,49(1):1-13. [42] LI M,LUO Q,GONG C,et al.Prospective surveillance of human adenovirus in acute respiratory infections reveals epidemiological features and the disappearance of species B during the COVID-19 pandemic in Beijing,China[J].J Infect,2022,85(4):436-480. [43] EL-HENEIDY A,WARE R S,ROBSON J M,et al.Respiratory virus detection during the COVID-19 pandemic in Queensland,Australia[J].Aust N Z J Public Health,2022,46(1):10-15. [44] OLSEN S J,WINN A K,BUDD A P,et al.Changes in influenza and other respiratory virus activity during the COVID-19 pandemic - United States,2020-2021[J].MMWR Morb Mortal Wkly Rep,2021,70(29):1013-1019. [45] WANG H,ZHENG Y,DE JONGE M I,et al.Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China[J/OL].Sci Rep,2022,12(1)[2022-11-04].http://doi.org/10.1038/s41598-022-21430-x. [46] MALDONADO-BARRUECO A,GARCÍA-RODRÍGUEZ J,YÁNIZ-RAMIREZ J,et al.Impact of the SARS-CoV-2 pandemic on the prevalence and incidence of gastrointestinal viruses in children up to five years old:a retrospective cohort study[J].Microbiol Spectr,2022,10(3)[2022-11-04].GARCÍA-RODRÍGUEZ J,YÁNIZ-RAMIREZ J,et al.Impact of the SARS-CoV-2 pandemic on the prevalence and incidence of gastrointestinal viruses in children up to five years old:a retrospective cohort study[J].Microbiol Spectr,2022,10(3)[2022-11-04].http://doi.org/10.1128/spectrum.02669-21. [47] YI H,LIN Y,LU B,et al.The origin of severe hepatitis of unknown aetiology in children:SARS-CoV-2 or adenovirus?[J/OL].J Hepatol,2022,77(1)[2022-11-04].https://doi.org/10.1016/j.jhep.2022.08.032. [48] ZHU M,CHEN L.Hepatitis of unknown etiology in children:what we know and what we can do?[J/OL].Front Microbiol,2022,13[2022-11-04].https://doi.org/10.3389/fmicb.2022.956887.