Abstract：Hypertensive disorders of pregnancy (HDP) are a common severe complication during pregnancy, which is characterized by complex etiology, unclear pathogenesis and lack of effective tools for early diagnosis and prediction. Recently, the development of omics technology provides new insights into the research into HDP. Based on national and international publications from 2011 to 2022, this review summarizes the application of genomics, proteomics, metabolomics, and microbiomics in the pathogenesis and prediction of HDP, so as to provide insights into the prediction, prevention and precise treatment of HDP.
徐佳惠, 卢莎, 胡文胜. 组学技术在妊娠期高血压疾病发病机制及预测研究中的应用进展[J]. 预防医学, 2023, 35(1): 36-40.
XU Jiahui, LU Sha, HU Wensheng. Application of omics in the pathogenesis and prediction of hypertensive disorders of pregnancy: a review. Preventive Medicine, 2023, 35(1): 36-40.
[1] 王昊,胡蓉.妊娠期高血压疾病与子代心血管疾病关系研究进展[J].现代妇产科进展,2022,31(1):72-74. [2] 鲁婕雨,石文翔,孔祥清.高血压代谢组学研究进展[J].南京医科大学学报(自然科学版),2021,41(2):286-291. [3] ESPLIN M S,FAUSETT M B,FRASER A,et al.Paternal and maternal components of the predisposition to preeclampsia[J].N Engl J Med,2001,344(12):867-872. [4] Wellcome Trust Case Control Consortium.Genome-wide association study of 14 000 cases of seven common diseases and 3 000 shared controls[J].Nature,2007,447(7145):661-678. [5] ZHAO L,TRICHE E W,WALSH K M,et al.Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients[J/OL].BMC Pregnancy Childbirth,2012,12[2022-11-27].http://doi.org/10.1186/1471-2393-12-61. [6] ZHAO L,BRACKEN M B,DEWAN A T.Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome(HAPO)study cohort[J].Ann Hum Genet,2013,77(4):277-287. [7] YANG X,YANG Y,YUAN Y,et al.The roles of uterine natural killer(NK) cells and KIR/HLA-C combination in the development of preeclampsia:a systematic review[J/OL].Biomed Res Int,2020[2022-11-27].https://doi.org/10.1155/2020/4808072. [8] HERUR A,AITHALA M,DAS K K,et al.Interplay of oxidative stress and nitric oxide synthase gene expression on cardiovascular responses in preeclampsia[J].Rev Bras Ginecol Obstet,2022,44(3):214-219. [9] LU F,GONG H,LEI H,et al.Downregulation of cathepsin C alleviates endothelial cell dysfunction by suppressing p38 MAPK/NF-κB pathway in preeclampsia[J].Bioengineered,2022,13(2):3019-3028. [10] DESHPANDE J S,SUNDRANI D P,SAHAY A S,et al.Unravelling the potential of angiogenic factors for the early prediction of preeclampsia[J].Hypertens Res,2021,44(7):756-769. [11] JIN X,XU Z,CAO J,et al.Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia[J].Biochim Biophys Acta Proteins Proteom,2017,1865(9):1207-1214. [12] MARY S,KULKARNI M J,MALAKAR D,et al.Placental proteomics provides insights into pathophysiology of pre-eclampsia and predicts possible markers in plasma[J].J Proteome Res,2017,16(2):1050-1060. [13] MA K,JIN H,HU R,et al.A proteomic analysis of placental trophoblastic cells in preeclampsia-eclampsia[J].Cell Biochem Biophys,2014,69(2):247-258. [14] 胡金艳,郭红霞,胡水旺,等.妊娠期高血压疾病与正常孕妇尿液蛋白质组分析[J].实用妇产科杂志,2013,29(6):446-449. [15] CARTY D M,SIWY J,BRENNAND J E,et al.Urinary proteomics for prediction of preeclampsia[J].Hypertension,2011,57(3):561-569. [16] ZHOU C,SONG C,HUANG X,et al.Early prediction model of gestational hypertension by multi-biomarkers before 20 weeks gestation[J].Diabetes Metab Syndr Obes,2021,14:2441-2451. [17] MYERS J E,TUYTTEN R,THOMAS G,et al.Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia[J].Hypertension,2013,61(6):1281-1288. [18] ZENG S,HAN M,JIANG M,et al.Serum complement proteomics reveal biomarkers for hypertension disorder of pregnancy and the potential role of Clusterin[J/OL].Reprod Biol Endocrinol,2021,19(1)[2022-11-27].http://doi.org/10.1186/s12958-021-00742-z. [19] BAHADO-SINGH R,POON L C,YILMAZ A,et al.Integrated proteomic and metabolomic prediction of term preeclampsia[J/OL].Sci Rep,2017,7(1)[2022-11-27].http://doi.org/10.1038/s41598-017-15882-9. [20] CHEN T,HE P,TAN Y,et al.Biomarker identification and pathway analysis of preeclampsia based on serum metabolomics[J].Biochem Biophys Res Commun,2017,485(1):119-125. [21] BAHADO-SINGH R O,SYNGELAKI A,MANDAL R,et al.Metabolomic determination of pathogenesis of late-onset preeclampsia[J].J Matern Fetal Neonatal Med,2017,30(6):658-664. [22] AUSTDAL M,TANGERÅS L H,SKRÅSTAD R B,et al.First trimester urine and serum metabolomics for prediction of preeclampsia and gestational hypertension:a prospective screening study[J].Int J Mol Sci,2015,16(9):21520-21538. [23] BAHADO-SINGH R O,AKOLEKAR R,MANDAL R,et al.Metabolomics and first-trimester prediction of early-onset preeclampsia[J].J Matern Fetal Neonatal Med,2012,25(10):1840-1847. [24] BAHADO-SINGH R O,AKOLEKAR R,MANDAL R,et al.First-trimester metabolomic detection of late-onset preeclampsia[J].Am J Obstet Gynecol,2013,208(1):e51-e57. [25] KUC S,KOSTER M P,PENNINGS J L,et al.Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia[J/OL].PLoS One,2014,9(5)[2022-11-27].http://doi.org/10.1371/journal.pone.0098540. [26] MUKHERJEE R,RAY C D,RAY S,et al.Altered metabolic profile in early and late onset preeclampsia:an FTIR spectroscopic study[J].Pregnancy Hypertens,2014,4(1):70-80. [27] RUAN W,ENGEVIK M A,SPINLER J K,et al.Healthy human gastrointestinal microbiome:composition and function after a decade of exploration[J].Dig Dis Sci,2020,65(3):695-705. [28] WANG J,SHI Z H,YANG J,et al.Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters[J].Chin Med J,2020,133(9):1057-1065. [29] CHANG Y,CHEN Y,ZHOU Q,et al.Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia[J].Clin Sci,2020,134(2):289-302. [30] WANG J,GU X,YANG J,et al.Gut microbiota dysbiosis and increased plasma LPS and TMAO levels in patients with preeclampsia[J/OL].Front Cell Infect Microbiol,2019,9[2022-11-27].http://doi.org/10.3389/fcimb.2019.00409. [31] BRANTSAETER A L,MYHRE R,HAUGEN M,et al.Intake of probiotic food and risk of preeclampsia in primiparous women:the Norwegian Mother and Child Cohort Study[J].Am J Epidemiol,2011,174(7):807-815. [32] NORDQVIST M,JACOBSSON B,BRANTSÆTER A L,et al.Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery:a prospective observational cohort study in Norway[J/OL].BMJ Open,2018,8(1)[2022-11-27].http://doi.org/10.1136/bmjopen-2017-018021. [33] GREV J,BERG M,SOLL R.Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants[J/OL].Cochrane Database Syst Rev,2018,12(12)[2022-11-27].http://doi.org/10.1002/14651858.CD012519.pub2. [34] MOVAGHAR R,FARSHBAF-KHALILI A,HAJIZADE K,et al.The effect of probiotics or synbiotics on the hypertensive disorders of pregnant women with gestational diabetes:a systematic review and meta-analysis[J].J Caring Sci,2022,11(2):94-104. [35] DAVIDSON S J,BARRETT H L,PRICE S A,et al.Probiotics for preventing gestational diabetes[J/OL].Cochrane Database Syst Rev,2021,4(4)[2022-11-27].http://doi.org/10.1002/14651858.CD009951.pub3. [36] KELL D B,KENNY L C.A dormant microbial component in the development of preeclampsia[J/OL].Front Med,2016,3[2022-11-27].http://doi.org/10.3389/fmed.2016.00060.
