|
|
An analysis on the clinical and epidemiological characteristics of 15 cases of human infection with avian influenza A (H7N9) virus in Jiaxing City |
QI Yun-peng,GU Wei-ling,FU Xiao-fei,XIE Liang,ZHA Yi-wei,ZHOU Wan-ling
|
The Center for Disease Control and Prevention of Jiaxing City,Jiaxing,Zhejiang,314050,China |
|
|
Abstract Objective To analyze the clinical and epidemiological characteristics of human avian influenza A (H7N9) epidemic in Jiaxing City,and to provide scientific basis for the control and prevention of the disease.Methods The epidemiological and clinical information of 15 cases of human infection with avian influenza A (H7N9) reported from April, 2013 to May, 2015 were collected.Sample of patients and external environmental samples of suspected exposure were collected and detected by real-time PCR.The epidemic distribution and clinical characteristics were analyzed.Results Fifteen cases of human infection with H7N9 were confirmed from April,2013 to May,2015, including 11 cases of death (77.33%). The confirmed cases mostly reported in winter and spring, and 9 confirmed cases were over 60 years, and male case proportion was higher than women (1.5∶1). Most of cases (66.67%) were sporadic and occurred in rural areas, but no epidemiological association was observed among the cases. Fever (100%), cough (66.67%), and wheezing and tightness in chest (33.33%) were common initial symptoms. The chest imaging examination of patients showed ground glass opacity and patchy consolidation, and 7 cases had simple pleural effusion. Twelve of confirmed cases had other chronic diseases.Eleven cases of death had appeared multiple medical comorbidities, such as respiratory failure (6/11), pulmonary embolism (4/11), multiple systemic organ failure (3/11), and heart cerebrovascular embolization (2/11). Twelve cases had been exposed to the live poultry markets where the positive rate of novel influenza A (H7N9) virus in environmental specimens was 7.69% (25/325). One of the 252 close contacts to confirmed cases appeared mild flu-like symptoms. No positive result related to novel influenza A (H7N9) virus nucleic acid was detected from each close contact's throat swabs.Conclusion Human infections with avian influenza A (H7N9) virus showed obvious seasonal distribution in Jiaxing. Elderly men, especially those with chronic diseases were the high risk people of human infection with H7N9 avian influenza.The infection might be associated with the exposure to live birds. Standard management of live poultry markets is the key measure in preventing and controlling H7N9 virus infection among population.
|
Published: 26 December 2017
|
|
|
|
|
[1]孙阳,沈银忠,林萍,等.新型禽流感:H7N9[J].检验医学,2013,28(9):739-744. [2]浙江省疾病预防控制中心.浙江省流感/禽流感监测工作季报[Z]2015. [3]中华人民共和国国家卫生和计划生育委员会.人感染H7N9禽流感疫情防控方案[Z].2014(1): 24-27. [4]任瑞琦,周蕾,向妮娟,等.中国内地人感染H7N9禽流感疫情流行病学特征分析[J].中华流行病学杂志,2014,35(12): 1362-1365. [5]童照威,王伟洪,李盛利,等.人感染H7N9禽流感临床特征及影像学分析[J].中华放射学杂志,2013,47(9): 834-835. [6]LU S H,LI T,XI X H,et al. Prognosis of 18 H7N9 avian influenza patients in Shanghai [J]. PLoS One,2014,9(4): e88728. [7]高明芬.浅析基层医院呼吸道传染病的防控[J].中国卫生产业,2013(32):48-49. [8]谢立,丁华,孙昼,等. 2013年杭州市人感染H7N9禽流感病例分布特征及暴露来源分析[J].中华流行病学杂志,2013,34(9): 944-945. [9]刘晓青,傅伟杰,谢昀,等.江西省人感染H7N9禽流感流行病学特征分析[J].中华疾病控制杂志,2015,19(3): 265-268. [10]许可,鲍倡俊.人感染H7N9禽流感流行病学研究进展[J].江苏预防医学,2015,26(1):43-47. [11]HE F,CHEN E F,LI F D,et al. Human infection and environmental contamination with Avian Influenza A (H7N9) Virus in Zhejiang Province, China: risk trend across the three waves of infection [J]. BMC Public Health,2015,15(1): 931. [12]李海,林玫,唐振柱,等.广西南宁市一起家庭聚集性人感染H7N9禽流感疫情的调查[J].中华流行病学杂志,2015,36(5): 481-483. [13]刘国贤,刘荣强,王正良,等.一起家庭聚集性人感染H7N9禽流感事件调查[J].实用预防医学,2015,22(7): 826-828. |
|
|
|