|
|
|
| Effects of fine particulate matter exposure on acute myocardial infarction mortality and life lost |
| LIANG Haiqing, RONG Sijing, KANG Huili, WANG Jun
|
| Haizhu District Center for Disease Control and Prevention, Guangzhou, Guangdong 510288, China |
|
|
|
|
Abstract Objective To investigate the effects of fine particulate matter (PM2.5) exposure on acute myocardial infarction (AMI) mortality and years of life lost (YLL). Methods Mortality data in Haizhu District, Guangzhou City from 2020 to 2024 were collected by the China Population Death Information Registration Management System and Guangdong Death Certificate Management System. Air pollution and meteorological data of the same period were obtained from the national environmental monitoring sites on the National Real-time Air Quality Release Platform and the Guangzhou Observatory, respectively. The single-pollutant model and multi-pollutant model were established by distributed lag non-linear model to analyze the effects of PM2.5 on AMI mortality and YLL. Results From 2020 to 2024, there were 2 466 AMI death cases in Haizhu District, including 949 males and 1 517 females. Among them, 530 cases were aged <65 years, 494 cases were aged 65-74 years, and 1 442 cases were aged >74 years. The median daily average number of deaths was 1.3 (interquartile range, 2.0) cases, and the median daily average YLL was 16.4 (interquartile range, 24.8) person years. The median daily average mass concentration of PM2.5 was 24.3 (interquartile range, 18.0) μg/m3. In single-pollutant models, the maximum effects of PM2.5 on AMI mortality and YLL were observed at a cumulative lag of 7 days. For per 10 μg/m3 increment in the daily average concentration of PM2.5, the excess risk of AMI mortality increased by 8.793% (95%CI: 4.201% to 13.588%), and YLL increased by 2.059 (95%CI: 1.081 to 3.037) person-years. Gender-stratified analyses showed that PM2.5 significantly affected AMI mortality in males and YLL in males and females (all P<0.05). Age-stratified analyses revealed that PM2.5 significantly affected AMI mortality and YLL among residents aged <65 years and 65-74 years (all P<0.05). However, the difference between genders or the two age groups was not statistically significant (both P>0.05). In multi-pollutant models, when NO2, SO2, or O3 were introduced respectively at a cumulative lag of 7 days, the effects of PM2.5 on AMI mortality and YLL were enhanced compared to the single-pollutant model (all P<0.05). When PM10 was introduced alone or in combination with PM10, SO2, NO2, and O3, the effects of PM2.5 on AMI mortality and YLL were not statistically significant (all P>0.05). Conclusion Exposure to PM2.5 may increase the risk of AMI mortality and YLL, with varying effects across populations of different genders and ages.
|
|
Received: 16 May 2025
Revised: 07 August 2025
Published: 20 November 2025
|
|
|
|
|
|
[1] 国家卫生健康委员会.2023中国卫生健康统计年鉴[M].北京:中国协和医科大学出版社,2024.
National Health Commission of China.China health statistics yearbook 2023[M].Beijing:Peking Union Medical College Press,2024.(in Chinese)
[2] 国家心血管病中心,中国心血管健康与疾病报告编写组.中国心血管健康与疾病报告2023概要[J].中国循环杂志,2024,39(7):625-660.
National Center for Cardiovascular Diseases,the Writing Committee of the Report on Cardiovascular Health and Diseases in China.Report on cardiovascular health and diseases in China 2023:an updated summary[J].Chin Circul J,2024,39(7):625-660.(in Chinese)
[3] GBD 2021 Risk Factors Collaborators.Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations,1990-2021:a systematic analysis for the Global Burden of Disease Study 2021[J].Lancet,2024,403(10440):2162-2203.
[4] World Health Organization.Global Health Observatory data repository:life tables by country China[EB/OL].[2025-08-07].https://apps.who.int/gho/data/view.main.60340?lang=en.
[5] CHEN C,ZHU P F,LAN L,et al.Short-term exposures to PM2.5 and cause-specific mortality of cardiovascular health in China[J].Environ Res,2018,161:188-194.
[6] HUANG K,DING K,YANG X J,et al.Association between short-term exposure to ambient air pollutants and the risk of tuberculosis outpatient visits:a time-series study in Hefei,China[J/OL].Environ Res,2020,184[2025-08-07].https://doi.org/10.1016/j.envres.2020.109343.
[7] HO A F W,HU Z X,WOO T Z C,et al.Ambient air quality and emergency hospital admissions in Singapore:a time-series analysis[J/OL].Int J Environ Res Public Health,2022,19(20)[2025-08-07].https://doi.org/10.3390/ijerph192013336.
[8] 曲玥,曾芳婷,陈凤格,等.石家庄市大气颗粒物对居民循环系统疾病死亡的寿命损失年影响的研究[J].现代预防医学,2023,50(3):426-431,450.
QU Y,ZENG F T,CHEN F G,et al.A study on the effect of atmospheric particulate matter on life lost years of death from circulatory diseases in Shijiazhuang[J].Mod Prev Med,2023,50(3):426-431,450.(in Chinese)
[9] 贾芯芮,杨升美,张晨光,等.2018—2021年PM2.5与呼和浩特市居民循环系统疾病死亡的关系分析[J].实用预防医学,2024,31(6):645-649.
JIA X R,YANG S M,ZHANG C G,et al.Relationship between PM2.5 and deaths due to circulatory system diseases among residents in Hohhot city,2018-2021[J].Pract Prev Med,2024,31(6):645-649.(in Chinese)
[10] 张文军,雷立健.2019—2020年阳泉市大气PM2.5污染与居民心血管疾病死亡效应的时间序列分析[J].实用预防医学,2023,30(8):908-912.
ZHANG W J,LEI L J.Time series analysis on the effect between atmospheric PM2.5 pollution and deaths from cardiovascular diseases among residents in Yangquan city,2019-2020[J].Pract Prev Med,2023,30(8):908-912.(in Chinese)
[11] 张开月,李小琴,夏俊鹏,等.大气PM2.5暴露对居民超额死亡的风险评估[J].预防医学,2024,36(11):950-952.
ZHANG K Y,LI X Q,XIA J P,et al.Excess mortality risk associated with atmospheric PM2.5 exposure[J].China Prev Med J,2024,36(11):950-952.(in Chinese)
[12] TIAN Y H,MA Y,WU J H,et al.Ambient PM2.5 chemical composition and cardiovascular disease hospitalizations in China[J].Environ Sci Technol,2024,58(37):16327-16335.
[13] 王照恩,卢海琼,王晨,等.不同来源PM2.5长期暴露对人群健康影响的研究进展[J].科学通报,2025,70(22):3616-3628.
WANG Z E,LU H Q,WANG C,et al.A review of advances in health effects from long-term exposure to PM2.5 from different sources[J].Sci Bull,2025,70(22):3616-3628(in Chinese)
[14] 李静,王焕新,屈龙,等.PM2.5对北京市昌平区居民心血管系统疾病死亡的短期影响[J].中华流行病学杂志,2019,40(3):331-334.
LI J,WANG H X,QU L,et al.Short term effect of PM2.5 on cardiovascular mortality in residents in Changping district,Beijing[J].Chin J Epidemiol,2019,40(3):331-334.(in Chinese)
[15] ZHANG Y Q.All-cause mortality risk and attributable deaths associated with long-term exposure to ambient PM2.5 in Chinese adults[J].Environ Sci Technol,2021,55(9):6116-6127.
[16] LUO H H,ZHANG Q L,YU K X,et al.Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity:a prospective study in the UK Biobank[J/OL].EBioMedicine,2022,84[2025-08-07].https://doi.org/10.1016/j.ebiom.2022.104282.
[17] 方博,李琦,晋珊,等.2013—2020年上海市空气动力学直径≤2.5 μm的颗粒物短期暴露导致的循环系统疾病超额死亡风险评估[J].疾病监测,2024,39(12):1547-1554.
FANG B,LI Q,JIN S,et al.Risk assessment of excess circulatory disease mortality attributed to short-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm in Shanghai,2013-2020[J].Dis Surveill,2024,39(12):1547-1554.(in Chinese)
[18] 赵静. 乌海市空气污染与心血管疾病死亡风险相关关系的研究[D].呼和浩特:内蒙古医科大学,2022.
ZHAO J.Study on the relationship between air pollution and cardiovascular disease mortality risk in Wuhai city[D].Hohhot:Inner Mongolia Medical University,2022.(in Chinese)
[19] 黄晓波,刘冠伦,梁永贤,等.深圳市道路扬尘化学组分特征及来源研究[J].当代化工研究,2024(18):105-107.
HUANG X B,LIU G L,LIANG Y X,et al.Study on chemical composition characteristics and sources of road dust in Shenzhen[J].Mod Chem Res,2024(18):105-107.(in Chinese) |
|
|
|
