|
|
|
| Adverse reactions to rabies vaccine for human use in China: a review |
| ZHAO Zhiyuan, ZHENG Limin
|
1. Xinzhou District Center for Disease Control and Prevention, Shangrao, Jiangxi 334000, China;
2. Shangrao Center for Disease Control and Prevention, Shangrao, Jiangxi 334000, China |
|
|
|
|
Abstract Rabies is an acute infectious disease caused by rabies virus with a high fatality rate. Post-exposure human rabies vaccination is an important measure to reduce the risk of rabies. Rabies vaccine is mainly used for post-exposure immunization with safety and tolerance. However, adverse reactions may occur in some recipients, mainly including local reactions such as pain, redness and swelling, and systemic reactions such as fever and headache. Usually, the symptoms are mild and self-limited, but severe adverse reactions in allergic patients may be life-threatening. The occurrence of adverse reactions to rabies vaccine for human use is closely related to individual differences, vaccine production process, and vaccination factors. The articles on adverse reaction of rabies vaccine for human use published in CNKI and PubMed database from 2006 to 2024 were retrieved. The incidence, causes and countermeasures of adverse reaction of rabies vaccine for human use were reviewed, so as to provide reference for reducing adverse reactions of rabies vaccine.
|
|
Received: 23 January 2025
Revised: 20 June 2025
Published: 23 July 2025
|
|
|
|
|
|
[1] 秦瑶,张倩,赖圣杰,等.2007—2023年中国狂犬病流行病学特征分析[J].中华实验和临床病毒学杂志,2024,38(4):373-377.
QIN Y,ZHANG Q,LAI S J,et al.Analysis of epidemic characteristics of human rabies in China in 2007-2023[J].Chin J Exp Clin Virol,2024,38(4):373-377.(in Chinese)
[2] 国家疾病预防控制局. 2023年全国法定传染病疫情概况[EB/OL].[2025-06-20].https://www.ndcpa.gov.cn/jbkzzx/c100016/common/content/content_1836299733133275136.html.
[3] 吴雪,郑立浩,阚绪伟,等.安吉县狂犬病暴露人群特征分析[J].预防医学,2023,35(4):327-330.
WU X,ZHENG L H,KAN X W,et al.Characteristics of populations exposed to rabies in Anji County[J].China Prev Med J,2023,35(4):327-330.(in Chinese)
[4] 来时明,尹志英,李俊姬,等.狂犬病疫苗两种不同免疫程序接种依从性及经济成本比较[J].预防医学,2017,29(8):857-860.
LAI S M,YIN Z Y,LI J J,et al.Comparison of vaccination compliance and economic costs of two different rabies vaccine immunization schedules[J].China Prev Med J,2017,29(8):857-860.(in Chinese)
[5] 张晓蕊,武治国,张文生.中国狂犬病疫苗不良反应发生率Meta分析[J].中华流行病学杂志,2017,38(6):821-827.
ZHANG X R,WU Z G,ZHANG W S.Adverse reaction caused by rabies vaccine in China:a meta-analysis[J].Chin J Epidemiol,2017,38(6):821-827.(in Chinese)
[6] 柏宁培,许濒月,王青.2006—2021年重庆市疑似预防接种异常反应监测分析[J].现代预防医学,2023,50(9):1711-1716.
BO N P,XU B Y,WANG Q.Analysis on the surveillance of adverse events following immunization in Chongqing from 2006 to 2021[J].Mod Prev Med,2023,50(9):1711-1716.(in Chinese)
[7] 吕亚可,王锐泽,李永东,等.2010—2021年陕西省疑似预防接种异常反应监测分析[J].中国生物制品学杂志,2024,37(6):696-702.
LYU Y K,WANG R Z,LI Y D,et al.Surveillance of adverse events following immunization in Shaanxi Province,2010-2021[J].Chin J Biologicals,2024,37(6):696-702.(in Chinese)
[8] 王易寒,李静,孙丽,等.2020—2022年河北省疑似预防接种异常反应监测分析[J].实用预防医学,2025,32(1):25-33.
WANG Y H,LI J,SUN L,et al.Surveillance of adverse events following immunization in Hebei Province,2020-2022[J].Pract Prev Med,2025,32(1):25-33.(in Chinese)
[9] WANG S Y,SUN J F,LIU P,et al.Immunogenicity and safety of human diploid cell vaccine(HDCV)vs. purified Vero cell vaccine(PVRV)vs. purified chick embryo cell vaccine(PCECV)used in post-exposure prophylaxis:a systematic review and meta-analysis[J/OL].Hum Vaccin Immunother,2022,18(1)[2025-06-20].https://doi.org/10.1080/21645515.2022.2027714.
[10] 华炜,张丽娟,叶建荣,等.接种狂犬病疫苗后发生腹型过敏性紫癜1例报告[J].预防医学,2017,29(2):180-181.
HUA W,ZHANG L J,YE J R,et al.One case report of abdominal allergic purpura after rabies vaccination[J].China Prev Med J,2017,29(2):180-181.(in Chinese)
[11] 赵欢欢,宋佳伟,刘金广,等.疫苗致5岁儿童肾病综合征1例分析[J].中国药物警戒,2023,20(11): 1303-1305.
ZHAO H H,SONG J W,LIU J G,et al.One case of nephrotic syndrome caused by rabies vaccine in a 5-year-old child[J].Chin J Pharmacov,2023,20(11):1303-1305.(in Chinese)
[12] 杜艳桃,张曼,张敏,等.狂犬病暴露后预防处置过程中疑似严重不良反应处置[J].实用预防医学,2023,30(9):1109-1112.
DU Y T,ZHANG M,ZHANG M,et al.Management of suspected severe adverse reactions during post-exposure prophylaxis for rabies[J].Pract Prev Med,2023,30(9):1109-1112.(in Chinese)
[13] 王达特. 接种冻干人用狂犬病疫苗(Vero细胞)后出现临床孤立综合征1例报告[J].实用预防医学,2019,26(6):738-739.
WANG D T.Clinically isolated syndrome after injecting freeze-dried purified Vero cell rabies vaccines:a report of one case[J].Pract Prev Med,2019,26(6):738-739.(in Chinese)
[14] 于敏敏,张金灵,吴海燕,等.狂犬疫苗致吉兰-巴雷综合征一例[J].中国神经免疫学和神经病学杂志,2017,24(5):379-380.
YU M M,ZHANG J L,WU H Y,et al.Rabies vaccine-associated Guillain-Barré Syndrome:a case report[J].Chin J Neuroimmunol & Neurol,2017,24(5):379-380.(in Chinese)
[15] 佟荟,李贵文,蒋静.接种冻干人用狂犬病疫苗(Vero细胞)后出现脱髓鞘性脊髓炎1例报告[J].公共卫生与预防医学,2021,32(2):126-128.
TONG H,LI G W,JIANG J.A case report on demyelinating myelitis occurring after vaccination of freeze-dried human rabies vaccine(Vero cells)[J].J Public Health Prev Med,2021,32(2):126-128.(in Chinese)
[16] 白云骅,邵忆楠,杨立清,等.国产冻干人用狂犬病疫苗(Vero细胞)上市后安全性观察[J].中国疫苗和免疫,2018,24(3):319-322.
BAI Y H,SHAO Y N,YANG L Q,et al.Post-marketing safety surveillance of Chinese freeze-dried rabies vaccine(Vero cell)for human use[J].Chin J Vaccines Immunization,2018,24(3):319-322.(in Chinese)
[17] DUNN S E,PERRY W A,KLEIN S L.Mechanisms and consequences of sex differences in immune responses[J].Nat Rev Nephrol,2024,20(1):37-55.
[18] 李小东,马俊清,石汉杰,等.赤峰市5 073名暴露者接种冻干人用狂犬病疫苗(Vero细胞)的不良反应分析[J].中国生物制品学杂志,2021,34(9):1085-1087.
LI X D,MA J Q,SHI H J,et al.Adverse reactions in 5 073 expose persons after immunization with freeze-dried rabies vaccine(Vero cells)for human use in Chifeng City,Inner Mongolia Autonomous Region,China[J].Chin J Biologicals,2021,34(9):1085-1087.(in Chinese)
[19] 王福娥,李霞,赵晓燕.狂犬疫苗接种后的不良反应的多种因素分析及有效措施[J].中国卫生产业,2015,12(32):46-48.
WANG F E,LI X,ZHAO X Y.A variety of factors rabies vaccination adverse reactions analysis and effective measures[J].China Health Industry,2015,12(32):46-48.(in Chinese)
[20] 刘晓宇,王艺楠,张少白,等.国产冻干人二倍体细胞狂犬病疫苗预防接种不良事件发生率和影响因素[J].中国疫苗和免疫,2022,28(6):699-703.
LIU X Y,WANG Y N,ZHANG S B,et al.Incidence of adverse events following immunization with a domestic human diploid cell-based rabies vaccine and factors influencing incidence[J].Chin J Vaccines Immunization,2022,28(6):699-703.(in Chinese)
[21] 徐娟,谢琴华.1例接种狂犬疫苗后发生疑似预防接种异常反应的调查[J].江苏预防医学,2024,35(3):385-387.
XU J,XIE Q H.A case investigation of suspected vaccine-associated adverse reaction post rabies vaccination[J].Jiangsu J Prev Med,2024,35(3):385-387.(in Chinese)
[22] 黄腾,李艳萍,莫顺平,等.国产CTN-1V株人用狂犬病疫苗(Vero细胞)在健康人群中的安全性及免疫原性[J].中国生物制品学杂志,2018,31(6):624-628,637.
HUANG T,LI Y P,MO S P,et al.Safety and immunogenicity of domestic rabies vaccine(Vero cells)for human use prepared with CTN-1V strain in healthy population[J].Chin J Biologicals,2018,31(6):624-628,637.(in Chinese)
[23] 赵鹭,左静,刘海文.人二倍体细胞狂犬疫苗两种纯化方式比较分析[J].河南预防医学杂志,2022,33(9):669-672.
ZHAO L,ZUO J,LIU H W.Comparative analysis of two purification methods of human diploid cell rabies vaccine[J].Mod Dis Control Prev,2022,33(9):669-672.(in Chinese)
[24] ALDRICH C,LEROUX-ROELS I,HUANG K B,et al.Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers:a phase 1 trial[J].Vaccine,2021,39(8):1310-1318.
[25] 国家疾控局综合司,国家卫生健康委办公厅.狂犬病暴露预防处置工作规范(2023年版)[J].中国病毒病杂志,2024,14(1):22-24.
General Department of the National Bureau of Disease Control and Prevention,General Office of the National Health Commission.Guidelines for the rabies postexposure prevention and disposal(2023 edition)[J].Chin J Viral Dis,2024,14(1):22-24.(in Chinese)
[26] 殷慧,杨茹怡,许萌,等.小儿接种狂犬病疫苗不良反应的观察及护理干预[J].实用临床医药杂志,2019,23(8):99-103,107.
YIN H,YANG R Y,XU M,et al.Observation on adverse reactions after rabies vaccine inoculation in children and its nursing intervention[J].J Clin Med Pract,2019,23(8):99-103,107.(in Chinese)
[27] BEYEA S C,NICOLL L H.Administration of medications via the intramuscular route:an integrative review of the literature and research-based protocol for the procedure[J].Appl Nurs Res,1995,8(1):23-33.
[28] 吴浩飞,王磊,葛灵睿,等.暴露后接种人用纯化狂犬病疫苗(Vero细胞)安全性的Meta分析[J].中国生物制品学杂志,2023,36(2):178-182.
WU H F,WANG L,GE L R,et al.Meta-analysis of safety of human purified Vero cell rabies vaccine after exposure[J].Chin J Biologicals,2023,36(2):178-182.(in Chinese)
[29] 张小燕.护理干预对预防接种狂犬疫苗不良反应的效果评价[J].临床医药文献电子杂志,2019,6(13):116,118.
ZHANG X Y.Evaluation of nursing interventions on preventing adverse reactions to rabies vaccination[J].Electron J Clin Medical Literature,2019,6(13):116,118.(in Chinese)
[30] 瞿建红,徐红.护理干预对12例狂犬疫苗接种后不良反应的效果分析[J].临床医药文献电子杂志,2020,7(3):84,98.
QU J H,XU H.Effectiveness Analysis of nursing interventions on 12 cases of adverse reactions following rabies vaccination[J].Electron J Clin Medical Literature,2020,7(3)84,98.(in Chinese)
[31] Centers for Disease Control and Prevention.About the Vaccine Adverse Event Reporting System(VAERS)[EB/OL].[2025-06-20].https://www.cdc.gov/vaccine-safety-systems/vaers/index.html.
[32] Public Health Agency of Canada.Canadian Adverse Events Following Immunization Surveillance System(CAEFISS)[EB/OL].[2025-06-20].https://www.canada.ca/en/public-health/services/immunization/canadian-adverse-events-following-immunization-surveillance-system-caefiss.html. |
| [1] |
CHEN Maofang, WU Ailan, XU Yuechen, JIN Xujing, ZHOU Pinpu, ZHANG Jing, CHEN Xiaoqing, JIN Feihua, WU Jianfeng. Effect evaluation of co-administration with bivalent human papilloma virus vaccine and hepatitis E virus vaccine[J]. Preventive Medicine, 2025, 37(7): 710-713. |
|
|
|
|
