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| Multiple roles of tumor microenvironment in epithelial-mesenchymal transition of tumor cells：a review |
| LI Zhuang, ZHOU Xinyue, LIU Xiayang, GUO Xiaohong
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| School of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430072, China |
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Abstract Metastasis of tumor cells poses great difficulties for tumor therapy. Tumor microenvironment is a complex and rich multicellular environment for the development of tumors, in which tumor-associated immune cells induce tumor cells to undergo epithelial-mesenchymal transition (EMT) which enhances the invasiveness and motility of tumor cells and prompts tumor cells to metastasize, and tumor cells undergoing EMT secrete cytokines and other substances to reorganize the tumor microenvironment. The interaction between EMT and the tumor microenvironment aggravate tumor invasion and metastasis. This paper collects research literature on tumor microenvironment and EMT of tumor cells from 2015 to 2023, and reviews the role of tumor microenvironment in tumor EMT, providing the basis for research into tumor metastasis mechanism and development of anti-tumor drugs.
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Received: 29 June 2023
Revised: 08 September 2023
Published: 10 October 2023
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