PM<sub>2.5</sub>对动脉粥样硬化的影响及机制

doi:10.19485/j.cnki.issn2096-5087.2021.10.010

Preventive Medicine

2021, Vol. 33

Issue (10): 1017-1021 DOI: 10.19485/j.cnki.issn2096-5087.2021.10.010

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The effect of fine particulate matter on atherosclerosis and its mechanism

CHEN Huan, LIU Yongsheng, YIN Yangguang

Department of Cardiology, Chongqing Hospital for Occupational Disease Prevention and Treatment, Chongqing 400060, China

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Abstract Fine particulate matter (PM_2.5) not only directly damages lung tissue, but also can be absorbed into blood through alveolar capillaries, which is toxic to the cardiovascular system. PM_2.5 can affect lipid metabolism, endothelial function, coagulation and thrombosis through oxidative stress, inflammatory reaction, autonomic nervous dysfunction and immune regulation abnormality, so that it promote arteriosclerosis, plaque instability, and increase the morbidity and mortality of cardiovascular disease. We reviewed the effects and mechanisms of PM_2.5 on arteriosclerosis, in order to provide the evidence for the studies into prevention of cardiovascular diseases caused by air pollution.

Key words： fine particulate matter atherosclerosis cardiovascular disease

Received: 26 April 2021 Revised: 02 June 2021 Published: 30 September 2021

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	CHEN Huan
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CHEN Huan,LIU Yongsheng,YIN Yangguang. The effect of fine particulate matter on atherosclerosis and its mechanism[J]. Preventive Medicine, 2021, 33(10): 1017-1021.

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