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| Advance in research of risk factors for hepatitis B cirrhosis progressing to primary hepatic carcinoma |
| JIAO Jiao*, GUO Yi-nan, ZHANG Guo-jun, YING Ling-ling, YE Wei-jiang
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| *First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310053,China |
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Abstract Primary hepatic carcinoma（PHC）is the second leading cancer that caused death in the world. The morbidity of PHC is increasing year by year,which threaten people's lives and health. Chronic hepatitis B is considered to be an independent risk factor for PHC,and the incidence of PHC is higher in patients who have progressed to liver cirrhosis. We reviewed the domestic and abroad literatures about the risk factors for hepatitis B cirrhosis progressing to PHC from the year of 1992 to 2018,and concluded that HBV-DNA,HBsAg,HBeAg expression,antiviral treatment time,different antiviral drugs,degree of cirrhosis,alanine transaminase and family history were related to the development of PHC from cirrhosis.
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Received: 11 November 2018
Revised: 17 January 2019
Published: 02 April 2019
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