Abstract:Objective To learn the temporal and spatial distribution of abnormalalanine aminotransferase(ALT)and its influencing factorsamong candidates for the high school entrance examination in Beijing,and to provide evidence for prevention of abnormal ALT in adolescents. Methods The physical examination data of the candidates in Beijing from 2009 to 2018 were collected from Beijing Physical Examination Center. The time,space and population distribution of abnormal ALT was analyzed;the time-space interaction trend of abnormal ALT was described by bubble map;and the Bayesian spatio-temporal model was built to explore the influencing factors of abnormal ALT in middle school students. Results Among 884 915 candidates,5 354 candidates had abnormal ALT,accounting for 0.61%. The rate of abnormal ALT showed an upward trend from 2009 to 2018(P<0.05).The rate of abnormal ALT was 0.95% in males and 0.23% in females,5.09% in obese candidates and 0.18% in non-obese ones,0.70% in urban area and 0.48% in rural area,and the differences between gender,obesity and residence were all statistically significant(P<0.05). From 2009 to 2018,the rates of abnormal ALT among the candidates in Changping District remained the highest;the rate in Shunyi District and Daxing District showed an increasing trend;the rates in Haidian District,Chaoyang District and Fengtai District were relatively high,the rates in Miyun District and Pinggu District were relatively low,while the trend of them were not obvious. The results of the Bayesian space-time model showed that the risk of abnormal ALT increased by 5.706 times for each unit increase of regional male percentage and increased by 8.679 times for each unit increase of regional obesity percentage. Conclusion The rate of abnormal ALT among candidates for the high school entrance examination in Beijing shows a upward trend. The rates of abnormal ALT among the candidates in Changping District,Haidian District,Chaoyang District and Fengtai District are relatively high,and the rates in Shunyi District and Daxing District tend to rise. Males and obese students are the high risk groups of abnormal ALT.
王晓峬, 郭秀花. 北京市中考学生ALT异常的时空分布特征分析[J]. 预防医学, 2019, 31(10): 977-981.
WANG Xiao-pu, GUO Xiu-hua. Spatial and temporal distribution of abnormal ALT among candidates for the high school entrance examination in Beijing. Preventive Medicine, 2019, 31(10): 977-981.
[1] KIM K E,BAEK K S,HAN S,et al.Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity[J]. Korean Journal of Pediatrics,2019,62(2):48. [2] WANG Z.Physical exercise and dietary habit to teenager physical quality influence difference research[J]. Journal of Computational and Theoretical Nanoscience,2016,13(12):10204-10208. [3] 殷正红,胡冬临.我国青少年体质健康问题及干预对策研究[J].当代体育科技,2017,7(29):18-19. [4] 陈孝祥,姜米佳,冯维良,等. 瑞安市高三学生谷丙转氨酶异常影响因素分析[J]. 中国学校卫生,2016,37(4):576-578,582. [5] 管军,徐烨. 青少年非酒精性脂肪肝相关危险因素分析[J]. 实用肝脏病杂志,2017,20(3):347-349. [6] 张灿. 大学新生入学时血清ALT异常情况及其相关影响因素分析[J]. 国际医药卫生导报,2018,24(10):1566-1568. [7] 王英慧,吴芊. 不同性别高校新生超重肥胖及高血压与血清丙氨酸氨基转移酶异常的相关性分析[J]. 现代预防医学,2017, 44(8):1520-1523. [8] 潘蕾,贺晓新,罗艳侠,等. 基于Bayes时空理论探讨北京市结核病演化特征及生态影响因素分析[J]. 中国卫生统计,2013,30(5):658-660. [9] FRASER A,LONGNECKER M P,LAWLOR D A.Prevalence of elevated alanine aminotransferase among US adolescents and associated factors:NHANES 1999-2004[J]. Gastroenterology,2007, 133(6):1814-1820. [10] ZHANG H,HE S M,SUN J,et al.Prevalence and etiology of abnormal liver tests in an adult population in Jilin,China[J]. Int J Med Sci,2011,8(3):254-262. [11] 白云,耿坤,徐志鑫. 2016年北京市昌平区成人超重肥胖流行特征及与常见慢性病的关系[J]. 职业与健康,2018,34(6):820-823. [12] 吴北平,杨典,王劲峰,等. 利用贝叶斯时空模型分析山东省手足口病时空变化及影响因素[J]. 地球信息科学学报,2016, 18(12):1645-1652. [13] 张强,孟令隆,牛吉攀. 非酒精性脂肪性肝病发病相关危险因素分析[J]. 实用肝脏病杂志,2017,20(6):756-757. [14] CHEN K W,MENG F C,SHIH Y L,et al.Sex-specific association between metabolic abnormalities and elevated alanine aminotransferase levels in a military cohort: The chief study[J]. International Journal of Environmental Research and Public Health,2018,15(3):545. [15] 杜凯音,张宝和,徐洪涛,等. 干部人群中超重、肥胖现状及影响因素分析[J]. 中国医药导报,2014,11(13):96-99,104. [16] WU S,DARBINIAN J,RAMALINGAM N,et al.The relationship of obesity severity,triglycerides,and elevated alt levels in adolescents[J]. Journal of the Endocrine Society,2019,3(Supp11): 20-23. [17] 骆波,徐谷,阮飞. 肥胖儿童载脂蛋白B/A1与颈总动脉内膜中层厚度的相关性分析[J]. 预防医学,2016,28(11):1110-1113. [18] DAS A K,CHANDRA P,GUPTA A,et al.Obesity and the levels of liver enzymes(ALT,AST & GGT)in East Medinipur,India[J]. Asian Journal of Medical Sciences,2015,6(1): 40-42.