Effects of bioactive peptides combined with probiotics on serum uric acid in patients with hyperuricemia
HAN Dan1, ZHAO Ya2, HUANG Enshan1, YE Shuhua3, WANG Wanjin4, WU Fangmin5, WANG Dingliang6, ZHANG Ronghua1
1. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China; 2. Hangzhou Medical College, Hangzhou, Zhejiang 310059, China; 3. Lanxi Hospital of Traditional Chinese Medicine, Lanxi, Zhejiang 321100, China; 4. Qiandao Lake Community Health Service Center of Chun'an County, Chun'an, Zhejiang 311700, China; 5. Meishan Health Hospital of Changxing County, Changxing, Zhejiang 313100, China; 6. Tongxiang Second People's Hospital, Tongxiang, Zhejiang 314511, China
Abstract：Objective To evaluate the effect of bioactive peptides combined with probiotics on serum uric acid (SUA) in patients with hyperuricemia (HUA), so as to provide the evidence for prevention and treatment of HUA. Methods The patients with HUA aged 18 to 65 years were selected and randomly divided into an intervention group and a control group. The patients in the intervention group received bioactive peptides combined with probiotics for 28 days at a dose of 3 g/d, while the patients in the control group received an equal dose of placebos. Demographic information, body mass index (BMI), blood pressure and blood lipid were collected through questionnaire surveys, physical examination and laboratory tests. SUA levels were detected before and after 14 days and 28 days of interventions. The differences of SUA levels between the two groups were compared using generalized estimation equation. Results Totally 108 patients with HUA were recruited, including 54 patients in the intervention group and 53 patients in the control group (1 dropout). Before interventions, there were no statistically significant differences in gender, age, course of HUA, exercise duration, frequency of alcohol consumption, frequency of meat broth consumption, BMI, prevalence of hypertension and prevalence of dyslipidemia between the two groups (all P>0.05). After 14 days of interventions, the SUA levels of the patients in the intervention group decreased by 3.00 μmol/L, while those in the control group increased by 7.00 μmol/L. After 28 days of interventions, the SUA levels of the patients in the intervention group and the control group decreased by 26.00 μmol/L and 16.00 μmol/L, respectively. However, there was no statistically significant interaction between the intervention time and group (both P>0.05). Subgroup analysis showed that after 28 days of interventions, the decrease in SUA levels in the patients aged 55 years and older and without hypertension in the intervention group was greater than those in the control group (both P<0.05). Conclusions Bioactive peptides combined with probiotics showed no significant difference in reducing SUA levels in patients with HUA compared to the control group. The effect was more significant for patients aged 55 years and older and without hypertension.
韩丹, 赵娅, 黄恩善, 叶树花, 汪万进, 吴方敏, 王定良, 章荣华. 生物活性肽联合益生菌干预对高尿酸血症患者血尿酸水平的影响[J]. 预防医学, 2025, 37(1): 40-45.
HAN Dan, ZHAO Ya, HUANG Enshan, YE Shuhua, WANG Wanjin, WU Fangmin, WANG Dingliang, ZHANG Ronghua. Effects of bioactive peptides combined with probiotics on serum uric acid in patients with hyperuricemia. Preventive Medicine, 2025, 37(1): 40-45.
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