Association between alcohol consumption and hyperuricemia among residents in Chengdu City
HAN Mingming1, WU Xinyu2, YANG Shujuan2, XIAO Xiong2, WEI Yonglan1, CHEN Heng3
1. Department of Chronic Non-Communicable Disease Control and Prevention, Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan 610041, China; 2. Sichuan University, Chengdu, Sichuan 610041, China; 3. Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan 610041, China
Abstract:Objective To analyze the association between alcohol consumption and hyperuricemia among residents in Chengdu City, so as to provide the evidence for prevention and control of hyperuricemia. Methods Based on the Natural Cohort Study in Southwest Area, residents at ages of 30 to 79 years were recruited in Chengdu City in 2018. Information of demographics, smoking, alcohol consumption and diet were collected through a questionnaire survey. Blood uric acid was tested in the laboratory. Participants were divided into never, moderate and excessive drinking groups based on alcohol consumption. A multivariable logistic regression model was used to analyze the association between alcohol consumption and hyperuricemia, and subgroup analysis was conducted according to gender, current residence, physical activity and body mass index (BMI). Results A total of 20 164 residents were investigated, including 8 776 males (43.52%) and 11 388 females (56.48%), with a mean age of (51.22±12.33) years. There were 9 769 never-drinkers (48.45%), 8 310 moderate-drinkers (41.21%), and 2 085 excessive-drinkers (10.34%). Hyperuricemia was detected in 4 101 patients, with a detection rate of 20.34%. Multivariable logistic regression analysis showed that moderate drinking (OR=1.122, 95%CI: 1.031-1.222) and excessive drinking (OR=1.529, 95%CI: 1.349-1.734) were associated with an increased risk of hyperuricemia. Moderate and excessive drinking were associated with an increased risk of hyperuricemia among men, urban residents, residents with a high level of physical activity, and those with BMI less than 24 kg/m2 (all P<0.05). Excessive drinking were associated with an increased risk of hyperuricemia among rural residents, residents with a low level of physical activity and with BMI of 24 kg/m2 and higher (all P<0.05). Conclusions Both moderate and excessive drinking are associated with an increased risk of hyperuricemia. Moderate drinking is not associated with a higher risk of hyperuricemia among rural residents, residents with a low level of physical activity and with BMI of 24 kg/m2 and higher.
[1] 沈益妹,章奇,朱新凤,等. 湖州市血压控制未达标高血压患者慢性病共病及影响因素分析[J]. 预防医学,2023,35(6):541-545,550. [2] LIU R,HAN C,WU D,et al. Prevalence of hyperuricemia and gout in mainland China from2000 to 2014:a systematic review and meta-analysis[J/OL]. Biomed Res Int,2015 [2023-11-04]. https://doi.org/10.1155/2015/762820. [3] 李萌,刘莹,王双,等.成都市体检人群连续8年血尿酸水平变化及高尿酸血症患病率分析[J].中医临床研究,2018,34(10):1-5. [4] LIU X R,HUANG S S,XU W D,et al. Association of dietary patterns and hyperuricemia:a cross-sectional study of the Yi ethnic group in China[J/OL]. Food Nutr Res,2018 [2023-11-04]. https://doi.org/10.29219/fnr.v62.1380. [5] 于莎莉,林晨,蒋志韬,等. 碱性饮用水预防小鼠高尿酸血症的作用研究[J]. 预防医学,2021,33(8):772-775,779. [6] LI R R,YU K,LI C W .Dietary factors and risk of gout and hyperuricemia:a meta-analysis and systematic review[J]. Asia Pac J Clin Nutr,2018,27(6):1344-1356. [7] LI Z,GUO X F,LIU Y M,et al. The relation of moderate alcohol consumption to hyperuricemia in a rural general population[J/OL]. Int J Environ Res Public Health,2016,13(7)[2023-11-04]. https://doi.org/10.3390/ijerph13070732. [8] 尤莉莉,乌云高娃,吴和平,等.内蒙古某地区男性超重肥胖和饮酒对血尿酸的影响[J].中国慢性病预防与控制,2013,21(6):659-662. [9] 中国营养学会. 中国居民膳食指南(2022)[M].北京:人民卫生出版社,2022. [10] 中华医学会内分泌学分会. 高尿酸血症和痛风治疗的中国专家共识[J]. 中华内分泌代谢杂志,2013,29(11):913-920. [11] DING X B,CHEN L L,TANG W G,et al.Interaction of harmful alcohol use and tea consumption on hyperuricemia among Han residents aged 30-79 in Chongqing,China[J]. Int J Gen Med,2023,16:973-981. [12] 马玉柱. 上海市某综合医院职工患高尿酸血症的影响因素分析及风险预测模型构建[D]. 南昌:南昌大学,2023. [13] 黄文,陈奇峰,李金,等. 越城区老年人饮酒及过量饮酒调查[J]. 预防医学,2021,33(10):1042-1045. [14] 玛依娜·卡哈尔,陈邬锦,张蓓,等.巴里坤县体检人群血清尿酸检测结果分析[J].预防医学,2022,34(3):244-247. [15] 黄佳乐,王新月,李红卫.厦门市居民高尿酸血症与膳食嘌呤摄入的相关性研究[J].营养学报,2019,41(1):20-23,29. [16] 唐国华,廖晓阳,袁波,等.成都地区无症状高尿酸血症伴心血管危险因素的城乡流行病学调查[J].中国循证医学杂志,2013,13(7):789-792. [17] ANGULO J,EL ASSAR M,ÁLVAREZ-BUSTOS A,et al.Physical activity and exercise:strategies to manage frailty [J/OL].Redox Biol,2020,35(8)[2023-11-04]. https://doi.org/10.1016/j.redox.2020.101513. [18] ALATALO P I,KOIVISTO H M,HIETALA J P,et al.Gender-dependent impacts of body mass index and moderate alcohol consumption on serum uric acid-an index of oxidant stress status?[J]. Free Radic Biol Med,2009,46(8):1233-1238.