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预防医学  2024, Vol. 36 Issue (9): 772-775,780    DOI: 10.19485/j.cnki.issn2096-5087.2024.09.009
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钒及其化合物毒性作用研究进展
李佳萍, 蒋兆强 综述, 李涛 审校
杭州医学院公共卫生学院,浙江 杭州 310013
Research progress on toxic effects of vanadium and its compounds
LI Jiaping, JIANG Zhaoqiang, LI Tao
School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang 310013, China
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摘要 钒因其可塑性、可锻性良好而广泛应用于钢铁制造、航空航天和医疗等行业,但大量钒化合物被排放到环境中,人类主要通过环境和职业暴露于钒。钒及其化合物可导致生殖系统、呼吸系统、神经系统和免疫系统等多系统损伤,其毒性作用机制可能与氧化应激、表观遗传损伤、DNA损伤、细胞凋亡及细胞增殖失调有关。本文对钒暴露导致的健康危害及其作用机制进行综述,为钒及其化合物的毒性作用研究提供参考。
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李佳萍
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关键词 毒性作用氧化应激DNA损伤机制    
Abstract:Vanadium is widely used in the steel manufacturing, aerospace and medical industries because of its good plasticity and malleability, and is released into the environment in large quantities. Human were exposed mainly through environmental and occupational exposure. Vanadium and its compounds can cause multi-system damage to the reproductive, respiratory, neurological, and immune systems, and the toxic mechanisms may be related to oxidative stress, epigenetic damage, DNA damage and repair, apoptosis, and dysregulation of cell proliferation. This article summarizes the health hazards caused by vanadium exposure and its mechanism, providing the reference for the studies into the toxic effects of vanadium and its compounds.
Key wordsvanadium    toxic effect    oxidative stress    DNA damage    mechanism
收稿日期: 2024-03-13      修回日期: 2024-07-03      出版日期: 2024-09-10
中图分类号:  R114  
基金资助:浙江省基础公益研究计划项目(LTGY23H260008); 浙江省医药卫生科技计划项目(2023KY654); 浙江省一流学科(A类)公共卫生与预防医学
作者简介: 李佳萍,硕士研究生在读,公共卫生与预防医学专业
通信作者: 李涛,E-mail:13456888808@163.com   
引用本文:   
李佳萍, 蒋兆强, 李涛. 钒及其化合物毒性作用研究进展[J]. 预防医学, 2024, 36(9): 772-775,780.
LI Jiaping, JIANG Zhaoqiang, LI Tao. Research progress on toxic effects of vanadium and its compounds. Preventive Medicine, 2024, 36(9): 772-775,780.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2024.09.009      或      http://www.zjyfyxzz.com/CN/Y2024/V36/I9/772
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