Mechanisms underlying the toxicity of microplastics to mammals: a review
ZHAO Qianxiu1, BAI Yuchao2, BAI Miao2, ZHANG Can2, ZHANG Chuanfu2
1. School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; 2. Center for Disease Control and Prevention of Chinese PLA, Beijing 100071, China
Abstract：As a new type of environmental pollutants, microplastics are widely distributed in the global ecosystem, and ingestion of microplastics may produce a number of toxic effects. Based on currently available publications, this paper describes the main pathways of exposure to microplastics, and summarizes the toxic mechanisms of microplastics in mammals, including oxidative stress, inflammatory response, immune damage, imbalance of gut microbiota, energy metabolism disorder and DNA damage, so as to provide insights into elucidation of the toxic mechanism mechanisms and health risk assessment of microplastics.
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