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预防医学  2018, Vol. 30 Issue (9): 893-896    DOI: 10.19485/j.cnki.issn2096-5087.2018.09.007
  论著 本期目录 | 过刊浏览 | 高级检索 |
金华市结核病患者耐药情况分析
张子根,郑浩,章光明
金华市疾病预防控制中心,浙江 金华 321002
Drug resistance of tuberculosis patients in Jinhua
ZHANG Zi-gen,ZHENG Hao,ZHANG Guang-ming
Jinhua Center for Disease Control and Prevention,Jinhua,Zhejiang 321002,China
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摘要 目的 了解金华市结核病患者的耐药情况,为个体化治疗和耐药结核控制提供依据。方法 对2015年7月1日—2016年6月30日金华市结核病定点医院报告的结核病患者痰标本进行菌型鉴定,对培养阳性并鉴定为结核分枝杆菌的标本进行药敏试验,分析其耐药率、耐药类型和耐药谱。结果 痰培养共获得菌株939株,鉴定为结核分枝杆菌869株,占92.55%。869例结核分枝杆菌培养阳性患者中,耐药168例,总耐药率为19.33%;耐药谱系比例最高为链霉素(4.60%),最低为乙胺丁醇(0.23%)。初治患者802例,复治患者67例;复治患者总耐药率、耐多药率和单耐药率分别为58.21%、29.85%和25.37%,均高于初治患者的16.08%、3.24%和10.22%(P<0.05);初治患者耐药率较高的为链霉素(4.36%)、异胭肼(3.24%)和氧氟沙星(1.62%);复治患者耐药率较高的为利福平+异胭肼(14.93%)、异胭肼(11.94%)、链霉素(7.46%)、利福平+异胭肼+乙胺丁醇+链霉素(5.97%)和氧氟沙星(4.48%)。结论 金华市结核病患者总耐药率为19.33%,且复治患者耐药情况比初治患者严重。
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张子根,郑浩,章光明
关键词 肺结核耐药初治复治    
AbstractObjective To understand the drug resistance of pulmonary tuberculosis(TB)patients in Jinhua and provide scientific basis for individualized treatment and the effective control of drug resistant TB. Methods The sputum specimens from TB patients reported in Jinhua TB hospital from July 1,2015 to June 30,2016 were identified. The drug sensitivity test was carried out for the specimens with positive culture and identified as Mycobacterium TB. The drug resistance rate,drug resistance type and drug resistance spectrum of the patients were analyzed. Results A total of 939 strains were obtained,and 869 strains were identified as Mycobacterium TB,accounting for 92.55%. Among the 869 TB patients,there were 168 cases of drug resistance,and the total resistance rate was 19.33%. The highest proportion of resistance spectrum was streptomycin(4.60%),and the lowest was ethambutol(0.23%). Of 869 TB patients,802 cases were first treated and 67 cases were retreated. The total resistance rate,multiple drug resistance rate and single drug resistance rate of the retreated patients were 58.21%,29.85% and 25.37%,which were higher than 16.08%,3.24% and 10.22% of the first treated patients (P<0.05). The drug resistance spectrum of the first treated patients was streptomycin(4.36%),isoniazide(3.24%)and ofloxacin(1.62%). The drug resistance spectrum of the retreated patients was rifampicin + isaziazide(14.93%),isoniazide(11.94%),streptomycin(7.46%),rifampicin + isaziazide + amethybutanol + streptomycin(5.97%)and ofloxacin(4.48%). Conclusion The total resistance rate of TB patients in Jinhua was 19.33%,and drug resistance in retreated patients was more severe than that in first treated patients.
Key wordsTuberculosis    Drug resistance    Initial treatment    Retreatment
          出版日期: 2018-09-04
中图分类号:  R521  
通信作者: 张子根,E-mail:jhcdczzg@126.com   
作者简介: 张子根,本科,主任医师,主要从事结核病和麻风防制工作
引用本文:   
张子根,郑浩,章光明. 金华市结核病患者耐药情况分析[J]. 预防医学, 2018, 30(9): 893-896.
ZHANG Zi-gen,ZHENG Hao,ZHANG Guang-ming. Drug resistance of tuberculosis patients in Jinhua. Preventive Medicine, 2018, 30(9): 893-896.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2018.09.007      或      http://www.zjyfyxzz.com/CN/Y2018/V30/I9/893
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