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预防医学  2023, Vol. 35 Issue (3): 185-189,195    DOI: 10.19485/j.cnki.issn2096-5087.2023.03.001
  论著 本期目录 | 过刊浏览 | 高级检索 |
大气NOX和NO2急性暴露与儿童呼吸系统疾病门诊量的关联研究
关新朋1, 徐洪兵1, 方嘉堃1, 朱雨桐1, 刘凌燕1, 赵茜1, 宋晓明1, 徐保平2, 黄薇1
1.北京大学公共卫生学院,北京 100191;
2.首都医科大学附属北京儿童医院,北京 100045
Correlation between atmospheric nitrogen oxides and nitrogen dioxide acute exposure and outpatient visits of pediatric respiratory diseases
GUAN Xinpeng1, XU Hongbing1, FANG Jiakun1, ZHU Yutong1, LIU Lingyan1, ZHAO Qian1, SONG Xiaoming1, XU Baoping2, HUANG Wei1
1. School of Public Health, Peking University, Beijing 100191, China;
2. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
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摘要 目的 分析交通相关大气污染物氮氧化物(NOX)和二氧化氮(NO2)急性暴露与儿童呼吸系统疾病门诊量的关联。方法 收集2015—2020年首都医科大学附属北京儿童医院呼吸系统疾病门诊就诊资料,通过北京大学医学部设置的监测点收集NOX、NO2及其他共存大气污染物资料;采用时间分层的病例交叉设计建立条件logistic回归模型分析NOX和NO2急性暴露与儿童呼吸系统疾病门诊量的关联。结果 2015—2020年首都医科大学附属北京儿童医院0~14岁儿童呼吸系统疾病日门诊量MQR)为571(554)人次,其中上呼吸道感染、支气管炎和肺炎的日门诊量MQR)分别为265(282)、143(178)和128(120)人次。大气NOX和NO2的日均浓度MQR)分别为67.8(50.7)和49.3(30.7)μg/m3。NOX和NO2急性暴露对儿童呼吸系统疾病的滞后效应均在累积滞后0~7 d时最大。NOX每升高一个QR浓度,上呼吸道感染、支气管炎和肺炎门诊就诊的超额风险分别为6.87%(95%CI:6.37%~7.38%)、7.25%(95%CI:6.51%~7.99%)和5.51%(95%CI:4.69%~6.33%);NO2每升高一个QR浓度,上呼吸道感染、支气管炎和肺炎门诊就诊的超额风险分别为5.71%(95%CI:5.12%~6.31%)、5.32%(95%CI:4.51%~6.14%)和4.83%(95%CI:3.91%~5.75%);对>5岁儿童的呼吸系统疾病门诊量影响更为明显。结论 交通相关大气污染物NOX和NO2急性暴露可能导致儿童呼吸系统疾病门诊量增加。
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关新朋
徐洪兵
方嘉堃
朱雨桐
刘凌燕
赵茜
宋晓明
徐保平
黄薇
关键词 儿童呼吸系统疾病交通相关大气污染门诊量    
AbstractObjective To examine the association between acute exposure to traffic-related air pollutants (TRAP) NOX and NO2 and outpatient visits of pediatric respiratory diseases. Methods Data regarding outpatient visits to Department of Respiratory Diseases of Beijing Children's Hospital from 2015 to 2020 were collected, and the concentrations of nitrogen oxides (NOX), nitrogen dioxide (NO2) and other TRAP were collected from the surveillance sites assigned by the Peking University Health Science Center. A time-stratified case-crossover design was employed, and a conditional logistic regression model was created to examine the association between NOX and NO2 acute exposure and outpatient visits of pediatric respiratory diseases. Results The daily mean outpatient visits of pediatric respiratory diseases were 571 (interquartile range, 554) person-times among children at ages of 0 to 14 years in Beijing Children's Hospital from 2015 to 2020, and the daily mean outpatient visits for upper respiratory tract infections (URI), bronchitis, and pneumonia were 265 (interquartile range, 282), 143 (interquartile range, 178) and 128 (interquartile range, 120) person-times, respectively. The daily mean concentrations of atmospheric NOX and NO2 were 67.8 (interquartile range, 50.7) and 49.3 (interquartile range, 30.7) μg/m3, respectively. Conditional logistic regression analysis showed the largest lagged effect of NOX and NO2 on pediatric respiratory diseases at cumulative lags of 0 to 7 days. An increase in NOX concentrations by an interquartile range resulted in the excess risks of URI, bronchitis and pneumonia by 6.87% (95%CI: 6.37%-7.38%), 7.25% (95%CI: 6.51%-7.99%), and 5.51% (95%CI: 4.69%-6.33%), and an increase in NO2 concentrations by an interquartile range resulted in excess risks of URI, bronchitis and pneumonia by 5.71% (95%CI: 5.12%-6.31%), 5.32% (95%CI: 4.51%-6.14%), and 4.83% (95%CI: 3.91%-5.75%), respectively. NOX and NO2 presented a more remarkable effect on outpatient visits of pediatric respiratory diseases among children at ages of over 5 years. Conclusion NOx and NO2 acute exposure may increase the outpatient visits of pediatric respiratory diseases.
Key wordschildren    respiratory diseases    traffic-related air pollution    outpatient visit
收稿日期: 2022-11-08      修回日期: 2023-02-08      出版日期: 2023-03-10
中图分类号:  R122.7  
基金资助:北京市自然科学基金(7222246)
作者简介: 关新朋,硕士研究生在读
通信作者: 黄薇,E-mail:whuang@bjmu.edu.cn   
引用本文:   
关新朋, 徐洪兵, 方嘉堃, 朱雨桐, 刘凌燕, 赵茜, 宋晓明, 徐保平, 黄薇. 大气NOX和NO2急性暴露与儿童呼吸系统疾病门诊量的关联研究[J]. 预防医学, 2023, 35(3): 185-189,195.
GUAN Xinpeng, XU Hongbing, FANG Jiakun, ZHU Yutong, LIU Lingyan, ZHAO Qian, SONG Xiaoming, XU Baoping, HUANG Wei. Correlation between atmospheric nitrogen oxides and nitrogen dioxide acute exposure and outpatient visits of pediatric respiratory diseases. Preventive Medicine, 2023, 35(3): 185-189,195.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2023.03.001      或      http://www.zjyfyxzz.com/CN/Y2023/V35/I3/185
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