Abstract：Objective To assess the impact of inclusion of hepatitis A vaccine in Expanded Program on Immunization（EPI）on hepatitis A incidence. Methods The data of patients with hepatitis A from 1998 to 2017 in Huzhou were collected through Huzhou Infectious Diseases Yearbook and China Disease Prevention and Control Information System. Interrupted time-series models were constructed using the year 2008 when hepatitis A vaccine was included in EPI as the intervention time point. The influence of hepatitis A vaccine into EPI on the hepatitis A incidence was evaluated by analyzing the changes in the level and slope of incidence before and after hepatitis A vaccine into EPI. Results Before the inclusion of hepatitis A vaccine in EPI,the average annual incidence rate of hepatitis A was 10.228/100 000 and the incidence of hepatitis A showed a significant descending trend with an annual decrement of 1.558/100 000. After the inclusion of hepatitis A vaccine in EPI,the average annual incidence rate of hepatitis A was 1.721/100 000 and the incidence of hepatitis A showed a significant descending trend with an annual decrement of 0.263/100 000. The average annual rate of decline in the hepatitis A incidence decreased by 1.295/100 000 after the inclusion of hepatitis A vaccine in EPI. Conclusion The incidence of hepatitis A significantly reduced after inclusion of hepatitis A vaccine in EPI,and the EPI strategy had a continuous effect on the decreasing trend of hepatitis A incidence.
张超, 罗小福, 徐秦儿. 应用中断时间序列评价甲肝疫苗纳入扩大免疫规划对甲肝发病的影响[J]. 预防医学, 2019, 31(6): 553-557.
ZHANG Chao, LUO Xiao-fu, XU Qin-er. Inclusion of hepatitis A vaccine in Expanded Program on Immunization on hepatitis A incidence by interrupted time-series analysis. Preventive Medicine, 2019, 31(6): 553-557.
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