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预防医学  2017, Vol. 29 Issue (12): 1231-1234    DOI: 10.19485/j.cnki.issn1007-0931.2017.12.010
  论著 本期目录 | 过刊浏览 | 高级检索 |
脑梗死与血脂及同型半胱氨酸水平的相关性研究
吴锐浩,周星星,周武,屠鸿翔,周铁丽
温州医科大学附属第一医院医学检验中心,浙江 温州 325000
The relationship between the level of serum lipid and homocysteine with cerebral infarction
WU Rui-hao,ZHOU Xing-xing,ZHOU Wu,TU Hong-xiang,ZHOU Tie-li
Medical Laboratory Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China
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摘要 目的 探讨脑梗死发生与同型半胱氨酸(Hcy)及血脂水平的相关性,为防制脑梗死提供参考。方法 纳入2 525例脑梗死住院患者及8 151名体检正常者为研究对象,采集研究对象清晨空腹静脉血,分别采用酶循环法和酶法进行血清Hcy和血脂水平检测,根据血脂检测结果计算动脉硬化指数(ASI),采用Logistic回归模型分析脑梗死发生的危险因素。结果 正常组男性4 952人,女性3 199人,平均(45.65±10.77)岁;脑梗死组男性1 590例,女性935例,平均(65.47±12.16)岁。正常组共检出高Hcy血症360人,检出率为4.42%,脑梗死组共检出高Hcy血症268人,检出率为10.61%,差异有统计学意义(P<0.01)。Logistic回归分析结果显示,高龄(OR=1.147,95%CI:1.140~1.154)、高Hcy(OR=1.022,95%CI:1.010~1.035)、高总胆固醇(OR=2.815,95%CI:2.603~3.045)、高ASI(OR=1.914,95%CI:1.794~2.042)是脑梗死发生的危险因素,女性(OR=0.694,95%CI:0.606~0.697)是脑梗死发生的保护因素。结论 血清Hcy、总胆固醇水平及ASI升高可增加脑梗死的发生风险,定期检测血清Hcy及血脂水平有助于及早发现和预防脑梗死。
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吴锐浩
周星星
周武
屠鸿翔
周铁丽
关键词 脑梗死同型半胱氨酸血脂动脉硬化指数    
AbstractObjective To investigate the correlation between cerebral infarction and homocysteine(Hcy)level and atherosclerosis index(ASI), and to provide reference for prevention and treatment of cerebral infarction. Methods 2 525 patients hospitalized with cerebral infarction and 8 151 healthy subjects were included in the study, the blood serum homocysteine and blood lipid levels were detected by enzymatic cycling and enzymatic method, and the ASI was calculated according to the results of blood lipid test. The risk factors of cerebral infarction were analyzed by logistic regression analysis model. Results The Physical examination Health Group male 4 952, female 3 199, average(45.65±10.77)years old, in the cerebral infarction Group male 1 590 cases, female 935, average(65.47±12.16)years old. A total of 360 patients with high homocysteine were detected in the Health examination group, the detection rate was 4.42%, the cerebral infarction group detected 268 patients with high homocysteine, the detection rate was 10.61%, and the difference was statistically significant (P<0.01). Logistic regression analysis showed that age(OR=1.147,95%CI:1.140~1.154), homocysteine (OR=1.022,95%CI:1.010~1.035)and total cholesterol(OR=2.815,95%CI:2.603~3.045)level, ASI(OR= 1.914,95%CI:1.794~2.042)are the risk factors of cerebral infarction, women(OR=0.694,95%CI:0.606~0.697)are the protective factors for the occurrence of cerebral infarction. Conclusion Serum homocysteine and total cholesterol levels, ASI elevated can increase the risk of cerebral infarction, regular detection of serum homocysteine and lipid levels can help early detection and prevention of cerebral infarction.
Key wordsCerebral infarction    Homocysteine    Blood lipid    Atherosclerosis index
     出版日期: 2017-12-07
ZTFLH:  R743.33  
通信作者: 周铁丽,E-mail:wyztli@163.com   
作者简介: 吴锐浩,本科,技师,主要从事医学检验工作
引用本文:   
吴锐浩,周星星,周武,屠鸿翔,周铁丽. 脑梗死与血脂及同型半胱氨酸水平的相关性研究[J]. 预防医学, 2017, 29(12): 1231-1234.
WU Rui-hao,ZHOU Xing-xing,ZHOU Wu,TU Hong-xiang,ZHOU Tie-li. The relationship between the level of serum lipid and homocysteine with cerebral infarction. Preventive Medicine, 2017, 29(12): 1231-1234.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.12.010      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I12/1231
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