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| A study on the effect of lactoferrin fortified formula milkon growth and blood erythrocyte indices among infants |
| CHAI Ling-ying, CHEN Ke, LI Hua, ZHANG Ying, XIE Hu-mi-na, SHANG Jia, TIAN Wei-zheng, YANG Ping
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| 1.Beingmate Baby & Child Food Co., Ltd., Hangzhou, Zhejiang,311106, China |
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Abstract Objective To explore the effect of lactoferrin fortified formula milk on growth and blood erythrocyte indices among infants. Methods In this prospective multi-center controlled intervention study, a total of 260 infants were selected from six maternal and children's health care hospitals in the area. All subjects were divided into two groups with the sequence of outpatient: lactoferrin fortified formula milk group (fortified group, FG, containing lactoferrin 38 mg/100 gmilk and iron element 4mg/100 g milk) and no lactoferrin fortified milk (control group, CG, containing lactoferrin 0 mg/100 g milk and iron element 4.2 mg/100 g milk) for 3 months. The levels of weight, height and head circumference and the concentration of hemoglobin (Hb), serum ferritin (SF), red blood cell count (RBC), hematocrit(Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cells volume distribution width (RDW) and HAZ, WAZ and WHZ were recorded before and after intervention, respectively. Results A total of 213 (including 115 in FG, and 98 in CG) infants were included in the intervention trial and all measurement of biochemical indicators were detected. There were no significant difference in the average amount of daily intake of formula milk (94.3±9.8 g vs. 88.2±8.7 g for FG and CG, P>0.05) and iron element (3.8±0.4 mg vs. 3.7±0.6 mg for FG and CG, P>0.05). The average amount of daily intake of lactoferrin for infants in FG group was 35.8±3.7 mg. The levels of weight, WAZ, WHZ, Hb, SF, MCV and MCHC of infants in FG after intervention were all significantly higher than those of infants in CG [weight, (8723±245)g vs. (8558±214)g; WAZ, (1.02±0.31) vs. (0.44±0.18); WHZ, (0.98±0.31) vs. (0.41±0.12); Hb, (125.5±15.4)g/L vs. (116.9±13.1) g/L; SF, (44.7±17.2) μg/L vs. (31.6±18.4) μg/L, but significantly lower for the prevalence of anemia (4.35% vs. 7.14%) and iron deficiency (13.91% vs. 24.49%) (P<0.05). Conclusion The intervention of lactoferrin fortified formula milk presented significant effects on iron metabolic homeostasis and erythrocyte indices of infant with breastfeeding.
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Published: 25 December 2017
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[1]MCLEAN E, EGLI I, BENOIST B, et al.Worldwide prevalence of anemia in preschool aged children, pregnant women and non-pregnant women of reproductive age [M]. Basel: Sight and life press,2007.
[2]BROCK J H. Lactoferrin-50 years on [J]. Biochemistry and Cell Biology, 2012, 90(3):245-251.
[3]中华人民共和国国家质量监督检验检疫总局,中国国家标准化管理委员会.食品安全国家标准-食品营养强化剂使用标准:GB 14880—2012[S].2012.
[4]DAVIDSSON L. Influence of lactoferrin on iron absorption from human milk in infants[J]. Pediatric Research,1994,35(1):117-124.
[5]JONSTON W H,ASHIEY C,YEISER M,et al. Growth and tolerance of formula with lactoferrin in infants through one year of age: double-blind, randomized, controlled trial[J]. BMC Pediatrics, 2015,15(1):173.
[6]HERNELL O, LNNERDAL B. Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides[J]. American Journal of Clinical Nutrition, 2002,76(4):858-864.
[7]CHEN K, LI T Y, CHEN L, et al. Effects of Vitamin A, Vitamin A plus iron and multiple micronutrient-fortified seasoning powder on preschool children in a suburb of Chongqing, China[J]. Journal of Nutritional Science and Vitaminology, 2008, 54 (6): 440-447.
[8]中华医学会围产医学分会. 妊娠期铁缺乏和缺铁性贫血诊治指南[J].中华围产医学杂志, 2014,17(7):451-454.
[9]PAESANO R, PIETROPAOLI M, GESSANI S, et al. The influence of lactoferrin, orally administered, on systemic iron homeostasis in pregnant women suffering of iron deficiency and iron deficiency anaemia [J]. Biochimie, 2009, 91(1):44-51.
[10]PAESANO R, BERLUTTI F, PIETROPAOLI M, et al. Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non-pregnant women [J]. International journal of immunopathology and pharmacology, 2009,23(2):577-587.
[11]KING J C, GUMMINGS G E, GUO N, et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants [J]. Journal of pediatric gastroenterology and nutrition,2007,44(2): 245-251.
[12]陈冠仪, 陈同辛, 陈惠金,等. 含乳铁蛋白配方奶粉喂养对婴儿生长发育和外周血细胞数值的影响[J]. 中国医师进修杂志,2011,34(15):52-54.
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