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| A study on cognitive impairment during depression remission stage |
| SUN Li-jun,WANG Xi-lin,HUANG Yue-qin
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| Peking University Institute of Mental Health, Key Laboratory of Mental Health,Ministry of Health (Peking University), Beijing, 100191, China |
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Abstract Objective To investigate the impairment and change of cognitive function in patients with depression in remission. Methods The cognitive function was evaluated with group neurocognitive test tool from multi-dimensional evaluation of attention, memory and execution function among 14 depressive patients during diseased episode and in remission after one year. The control group was set and the results of the two groups were compared. Results The result of the attention test showed that the error counts of the second and third situation of Continuous Performance Test (CPT) in depression group in diseased episode and in remission were more than those in the control group (P<0.05), and the time used in Stroop-C and the time used in A of Trail making test(TMT) were longer than those in the control group (P<0.05), and the right numbers in Stroop-CW were less than those in the control group (P<0.05). The numbers completed in Stroop-CW in diseased episode of depression group were less than those in control group(P<0.05), and the numbers completed in Stroop-CW in remission of depression group were more than those in diseased episode(P<0.01). The result of the memory test showed that the score of a in Logical memory test (LMT) in diseased episode of depression group was less than that in control group(P<0.05), and the score of b and aggregate score in LMT and the score of b in Visal reproduction test (VRT) in diseased episode and in remission of depression group were less than that in control group (P<0.05). In VRT, the score of a and aggregate score in diseased episode were less than that in remission of depression group and in control group(P<0.05), and the score of c in diseased episode and the aggregate score in remission were less than that in control group(P<0.05).The result of the execution function test showed that the numbers of sustained error of mWCST in diseased episode of depression group were more and the numbers of categories were less than those in control group (P<0.05), and the correct numbers in Verbal fluency test (VFT) of the depressive group in diseased episode and in remission were less than those in control group(P<0.01). Conclusion When the depressive disorder is remitted, the degree of cognitive impairment in different dimension is different, and the cognitive impairment is still exist for a long time.
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Published: 25 December 2017
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