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| A study on the relationship between ApoB/ApoA1 and carotid intima-media thickness among obese children |
| LUO Bo, XU Gu, RUAN Fei
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| The Zhuji People’s Hospital, Shaoxing, Zhejiang, 311800, China |
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Abstract Objective To explore the relationship between ApoB/ApoA1 ratio and the common carotid arterial intima-media thickness (CCA IMT) among obese children.Methods A total of 53 obese children in the Zhuji People's hospital outpatient were enrolled as obese group. Other 59 no-obese healthy children were recruited as control group. Serum fasting glUAose (FG), fasting insulin (FI), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein A, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), alanine aminotransferase (ALT), aspartate amino transferase (AST), and uric acid (UA) were measured in the clinical laboratory.Body mass index (BMI), waist to hipline (W/H) ratio,ApoB/ApoA1 ratio, insulin resistance by homeostasis model (HOMA-IR), and β cell function by homeostasis model (HOMA-β) were calculated. The common carotid arterial IMT of obese children was measured by B-mode ultrasound. All factors between two groups were compared by independent t test. The differences between the two groups were compared, and the correlation between CCA IMT and other factors in obesity group was analyzed by stepwise multiple regression model.Results In the obese group, lg(ALT), lg(AST), lg(UA), ln(10*TG), TC, LDL-C, ApoB, ApoB/ApoA1, lg(HOMA-β), and ln(10* HOMA-IR) were significantly higher than those in control group (P<0.05, respectively) while HDL-C and ApoA1 in obese group were lower than those in control group (P<0.01, respectively). Bivariate correlation analysis showed that CCA IMT was inversely correlated with ApoA1 and positively correlated with ApoB/ApoA1, lg(ALT), and lg(AST) (P<0.05, respectively). Analysis using multiple regression method showed that ApoB/ApoA1 was positively correlated with CCA IMT in these obese children (P<0.05). Conclusion In obese children, ApoB/ApoA1 was the作者简介骆波,本科,主治医师,主要从事儿科内分泌工作通信作者徐谷,E-mailandia-82710@163.comindependent determinant of CCA IMT, which may be a risk factor for atherosclerosis early in life.
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Received: 16 May 2016
Published: 11 December 2017
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