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| Trend in disease burden of lung cancer in cancer registration areas of Guizhou Province from 2017 to 2021 |
| ZHOU Jie, ZHANG Ji, JI Wei, REN Yujin, WU Yanli, LI Ling
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| Guizhou Provincial Center for Disease Control and Prevention, Guiyang, Guizhou 550004, China |
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Abstract Objective To investigate trends of incidence, mortality, and years of life lost (YLL) rate of lung cancer in cancer registration areas of Guizhou Province from 2017 to 2021, so as to provide references for formulating lung cancer prevention and control strategies and reducing the disease burden of lung cancer. Methods The qualified lung cancer registration data from cancer registration areas of Guizhou Province from 2017 to 2021 were collected, the crude incidence and mortality of lung cancer were calculated by urban/rural areas, genders and ages. The standardized incidence and standardized mortality was calculated using the age structure of the standard population from the Fifth National Population Census in 2000. YLL was calculated using the standard life table from the Global Burden of Disease Study 2019. The disease burden of lung cancer was assessed using incidence, mortality, and YLL rate, and the trend in the disease burden of lung cancer from 2017 to 2021 was calculated using annual percent change (APC). Results From 2017 to 2021, the crude incidence, standardized incidence, crude mortality, standardized mortality, YLL and YLL rate in Guizhou Province were 53.13/105, 37.58/105, 42.77/105, 29.44/105, 98.19 thousand person-years and 10.95‰, respectively. The standardized incidence and standardized mortality of lung cancer were higher in rural areas than in urban areas (39.45/105 vs. 34.23/105, 30.68/105 vs. 27.18/105). The standardized incidence and standardized mortality of lung cancer were higher in males than in females (49.34/105 vs. 26.47/105, 41.31/105 vs. 18.28/105). The crude incidence and crude mortality of lung cancer increased with age, peaking in the 80-<85 age group (360.84/105) and the ≥85 age group (414.85/105), respectively. From 2017 to 2021, the standardized incidence demonstrated downward trends in the total population, urban areas and males (APC=-6.590%, -5.829%, and -6.729%, all P<0.05). The standardized mortality demonstrated downward trends in urban areas and females (APC=-3.710% and -5.378%, both P<0.05). The YLL rate also showed downward trends in urban areas and females (APC=-3.957% and -3.631%, both P<0.05). Conclusions From 2017 to 2021, the overall disease burden of lung cancer in registration areas of Guizhou Province showed a decreasing trend. However, the disease burden remained relatively heavier in rural areas and males, with a relatively gradual change.
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Received: 10 September 2025
Revised: 25 September 2025
Published: 23 October 2025
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