|
|
|
| A study on the clinical value of oxidative stress related index in chronic kidney disease diagnosis |
| YANG Ye-qing, LIU Bo, XU Guang-ping, CHEN Xiao-hua, MAO Xian-ya
|
| Clinical Laboratory of the Second Hospital Affiliated of Zhejiang Chinese Medicine University, Hangzhou,Zhejiang,310005, China |
|
|
|
|
Abstract Objective To evaluate the clinical value of oxidative stress related indicators in chronic kidney disease (CKD)diagnosis.Methods A total of 220 CKD patients in different stages and 100 healthy persons were enrolled. The serum levels of Creatinine (Cr), uric acid (UA),γ-glutamyl transpeptidase (GGT) and homocysteine (HCY) were measured. CKD patients were divided into 5 stages according to the calculated estimated glomerular filtration rate (eGFR). CKD patients in stage 1, 2 were incorporated as group CDKⅠand incorporating CKD patients in stage 3, 4, 5 patients were incorporated as group CDKⅡ.T test was used to compare the difference of UA, GGT, HCY levels between healthy people and CKD patients. Receiver operating characteristic (ROC) curve was used to evaluate the clinical value of each index in CKD diagnosis. Z test was used to compare the difference of the area under curve (AUC) of UA, GGT, HCY and combined detection.Results The mean levels of serum UA, GGT, HCY between CKD patients and healthy person were statistically significant (P<0.05). In healthy persons and CKD patients study, the AUC of UA, GGT, HCY and combined detection were 0.823, 0.585, 0.850 and 0.924, respectively. The AUC of combined detection was significantly higher than single detection (P<0.05). In group CDKⅠ andⅡ study, the AUC of UA, GGT, HCY and combined detection were 0.719, 0.485, 0.828 and 0.834, respectively. The AUC of combined detection was not significantly higher than HCY detection (P>0.05)Conclusion Combined detection of oxidative stress related index has high application value in CKD early diagnosis.
|
|
Received: 25 August 2016
Published: 21 November 2017
|
|
|
|
|
|
[1]YANO Y,FUJIMOTO S,ASAHI K,et al.Prevalence of chronic kidney disease in China[J].Lancet,2012,379(9 818):815-822.
[2]佟苏东. 氧化应激与肾脏损伤[J]. 医学信息, 2013,26(13):589.
[3]EKNOYAN G,LEVIN N. NKF-K/DOQI clinical practice guidelines: update 2000. Foreword. [J]Am J Kidney Dis,2001 ,37(Suppl 1):S5-6.
[4]张路霞,王海燕. 中国慢性肾脏病的高患病率及其对检验医学的挑战 [J]. 中华检验医学杂志,2012,35(9):35-35.
[5]MA Y C,ZUO L, CHEN J H,et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease[J]. J Am Soc Nephrol,2006,17(10):2937-2944.
[6]董杨,程丽静. 高尿酸血症对慢性肾脏病的作用及机制研究 [J]. 微循环学杂志,2016,26(1):72-74.
[7]王朔,郭晓临. 血清γ谷氨酰转肽酶与慢性肾脏病危险因素关系的研究 [J]. 中国血液流变学杂志,2013,23(2):346-348.
[8]高玉英. 同型半胱氨酸测定在肾脏疾病中的应用 [J]. 中国药物与临床,2015,15(5):734-735.
[9]RYU E S,KIM M J,SHIN H S,et al. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease [J] Am J Physiol Renal Physiol, 2013,304(5):F471-480.
[10]张燕, 常保超, 王静. 慢性肾脏病患者血尿酸、C反应蛋白的变化及其对心血管事件的影响[J]. 蚌埠医学院学报, 2012, 37(7):769-772.
[11]孙晓琦, 方南元, 薛博瑜. GGT与非酒精性脂肪肝及相关疾病的研究进展[J]. 世界华人消化杂志, 2014(31):4745-4749.
[12]何煜, 张琰, 廖婷婷,等. 还原型谷胱甘肽对早期2型糖尿病肾病氧化应激状态的影响[J]. 华夏医学, 2013, 26(4):670-673.
[13]XIE D,YUAN Y,GUO J,et al.Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults [J]. Scientific Reports,2015(5):16268.
[14]FOTIOU P,RAPTIS A,APERGIS G,et al. Vitamin status as determinant of serum homocysteine concentration in type 2 diabetic retinopaty [J]. J Diabetes Res,2014,2014(16):807209.
[15]LEVI A,COHEN E,LEVI M,et al. Elevated serum homocysteine is a predictor of accelerated decline in renal function and chronic kidney disease:a historical prospective study [J]. European Journal of Internal Medicine,2014,25(10):951-955.
[16]徐香芬, 吴燕, 李磊. 常用乳腺癌筛查方法诊断价值的应用评价[J]. 浙江预防医学, 2014,26(5):454-458.
[17]丁小强. 努力提高慢性肾脏病的防治水平[J]. 上海医学, 2014,37(5):357-359.
[18]王培红, 陈晓丽. 替米沙坦对3期慢性肾脏病患者微炎症和氧化应激状态及肾功能的影响[J]. 中国药物与临床, 2012, 12(6):796-797.
[19]骆莹莹, 陈述, 王大新. 氧化应激对动脉粥样硬化内皮细胞损伤作用的研究进展[J]. 医学综述, 2015,21(5):772-775.
[20]王昱,鲍晓荣. 氧化应激在尿酸致早期慢性肾脏病血管内皮损伤中的作用 [J]. 中国中西医结合肾病杂志,2010,11(5):404-406. |
| No related articles found! |
|
|
|
|
