常州市老年肺结核患者利福平耐药分析

doi:10.19485/j.cnki.issn2096-5087.2024.02.018

Preventive Medicine

2024, Vol. 36

Issue (2): 162-164,168 DOI: 10.19485/j.cnki.issn2096-5087.2024.02.018

Disease Control

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Rifampicin resistance among elderly patients with pulmonary tuberculosisin Changzhou City

WU Yujiao¹, ZUO Xiaoming¹, QIN Keyu², ZHANG Zhixin², ZHANG Xing³

1. Department of Pharmacy, Changzhou Third People's Hospital, Changzhou, Jiangsu 213000, China;
2. Changzhou Third People's Hospital, Changzhou, Jiangsu 213000, China;
3. Changzhou Center for Disease Control and Prevention, Control, Changzhou, Jiangsu 213000, China

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Abstract Objective To investigate the rifampicin resistance status and its influencing factors among elderly patients with pulmonary tuberculosis in Changzhou City, Jiangsu Province, so as to provide the basis for improving drug-resistant pulmonary tuberculosis prevention and control strategies. Methods Patients aged over 60 years with pulmonary tuberculosis treated in tuberculosis designated hospital was selected. Demographic information, history of previous disease, history of diagnosis and treatment and drug sensitivity test were collected. Rifampicin resistance among elderly patients with pulmonary tuberculosis and its influencing factors was analyzed. Results Totally 249 elderly patients with pulmonary tuberculosis were included, with an average of (69.75±4.36) years. There were 147 males and 102 females, with a gender ratio of 1.44∶1. There were 183 treatment-naïve patients (73.49%) and 66 retreated patients (26.51%). Rifampicin resistance was found in 21 cases, with a drug resistance rate of 8.43%. Among them, there were 7 treatment-naïve patients (3.83%), and 14 retreated patients (21.21%). Multivariable logistic regression analysis showed that retreated elderly patients with pulmonary tuberculosis had a higher risk of rifampicin resistance (OR=10.551, 95%CI: 1.344-82.857). Conclusion The rifampicin resistance rate of 249 elderly patients with pulmonary tuberculosis was 8.43% and was associated with the type of treatment.

Key words： the elderly pulmonary tuberculosis rifampicin resistance influencing factor

Received: 11 September 2023 Revised: 08 January 2024 Published: 21 February 2024

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Cite this article:

WU Yujiao,ZUO Xiaoming,QIN Keyu, et al. Rifampicin resistance among elderly patients with pulmonary tuberculosisin Changzhou City[J]. Preventive Medicine, 2024, 36(2): 162-164,168.

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http://www.zjyfyxzz.com/EN/10.19485/j.cnki.issn2096-5087.2024.02.018 OR http://www.zjyfyxzz.com/EN/Y2024/V36/I2/162

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