|
|
|
| Surveillance of suspected adverse events following immunization in Wuyi County from 2018 to 2021 |
| WANG Xiaoliu, TANG Yuanfei
|
| Department of Immunization Planning, Wuyi Center for Disease Control and Prevention, Wuyi, Zhejiang 321200, China |
|
|
|
|
Abstract Objective To investigate the occurrence of suspected adverse events following immunization (AEFI) in Wuyi County, Zheijang Province from 2018 to 2021, so as to provide insights into safety assessment of vaccination. Methods The AEFI data in Wuyi County from 2018 to 2021 were collected from the AEFI Information Management System and Immunization Information Management System of National Immunization Information Management System in China. The reported incidence of AEFI and epidemiological characteristics of cases with AEFI were analyzed in Wuyi County from 2018 to 2021 using a descriptive epidemiological method. Results A total of 870 007 vaccine doses had been administered in Wuyi County from 2018 to 2021, and a total of 482 AEFI were reported, with annual mean reported incidence of 55.40/105. The incidence of AEFI associated with vaccines included in the national immunization program was significantly higher than those not included in the national immunization program (67.75/105 vs. 44.00/105; χ2=20.334, P<0.001). There were 435 individuals with general reactions (50.00/105 incidence), with high fever, local redness and swelling and solid nodes; 39 cases with abnormal reactions (4.48/105 incidence), including 87.18% allergic reactions; 7 cases with coincident syndrome and one case with psychogenic reaction; however, no vaccine quality or vaccination events were reported. The five vaccines with the greatest incidence of AEFI included 13-valent pneumococcal polysaccharide conjugate vaccine (269.11/105), diphtheria and tetanus toxoids and acellular pertussis, inactivated poliovirus and Haemophilus b conjugate vaccine (204.23/105), 23-valent pneumococcal polysaccharide vaccine (175.85/105), tetanus, diphtheria, acellular pertussis vaccine (128.39/105) and combined live vaccine for measles, mumps and rubella (124.36/105). The reported incidence rates of AEFI were 10.89/105, 49.88/105, 56.07/105 and 57.78/105 following oral, intradermal, subcutaneous and intramuscular administrations, respectively. In addition, AEFI were predominantly found to occur in patients at ages of 0 to <2 years (333 cases, 69.09%), and AEFI predominantly occurred <1 day following immunization (336 cases, 69.71%). Conclusions General reactions were predominant types of AEFI following vaccination in Wuyi County from 2018 to 2021, and the reported incidence of AEFI associated with vaccines included in the national immunization program was significantly higher than those not included in the national immunization program. AEFI mainly occurred among children under 2 years of age.
|
|
Received: 21 July 2022
Revised: 25 September 2022
Published: 16 November 2022
|
|
|
|
|
|
[1] 中华人民共和国卫生部办公厅,国家食品药品监督管理局办公室.全国疑似预防接种异常反应监测方案[J].中国疫苗和免疫,2011,17(1):72-81.
General Office of Ministry of Health,General Office of State Administration for Food and Drug.National guideline for surveillance of adverse events following immunization[J].Chin J Vaccine Immunization,2011,17(1):72-81.
[2] 汤元妃. 2012—2014年武义县疑似预防接种异常反应监测分析[J].中国农村卫生事业管理,2016,36(7):875-877.
TANG Y F.Surveillance and analysis of adverse events following immunization in Wuyi County from 2012 to 2014[J].Chin Rural Health Serv Adm,2016,36(7):875-877.
[3] 张丽娜,李克莉,杜雯,等.2019年中国疑似预防接种异常反应监测[J].中国疫苗和免疫,2021,27(4):438-445.
ZHANG L N,LI K L,DU W,et al.Surveillance of adverse events following immunization in China,2019[J].Chin J Vaccine Immunization,2021,27(4):438-445.
[4] 张丽娜,李克莉,李燕,等.2020年中国疑似预防接种异常反应监测[J].中国疫苗和免疫,2022,28(2):208-217.
ZHANG L N,LI K L,LI Y,et al.Surveillance of adverse events following immunization in China,2020[J].Chin J Vaccine Immunization,2022,28(2):208-217.
[5] 郑祎,王丹丹,王梅玉婷,等.2016—2020年嘉兴市南湖区疑似预防接种异常反应监测分析[J].预防医学情报杂志,2021,37(9):1256-1263,1268.
ZHENG Y,WANG D D,WANG M Y T,et al.Surveillance and analysis of suspected adverse reactions to vaccination in Nanhu District of Jiaxing City from 2016 to 2020[J].J Prev Med Inf,2021,37(9):1256-1263,1268.
[6] 吴晓虹,章光明.金华市2015—2016年疑似预防接种异常反应监测分析[J].上海预防医学,2017,29(9):707-711.
WU X H,ZHANG G M.Surveillance analysis on adverse events following immunization in Jinhua in 2015-2016[J].Shanghai J Prev Med,2017,29(9):707-711.
[7] 周绍英,马瑞.宁波市疑似预防接种异常反应监测结果分析[J].预防医学,2018,30(3):274-277.
ZHOU S Y,MA R.Analysis on surveillance results of adverse events following immunization in Ningbo City[J].Prev Med,2018,30(3):274-277.
[8] 吴瑛,李瑞平,高彩红.2010—2020年上海市奉贤区南桥镇疑似预防接种异常反应监测数据分析[J].职业与健康,2022,38(5):654-657.
WU Y,LI R P,GAO C H.Analysis on surveillance data of adverse event following immunization in Nanqiao Town of Fengxian District in Shanghai from 2010-2020.[J].Occup Health,2022,38(5):654-657.
[9] 严波,周倩意,郑晓晖,等.中国儿童家长疑似预防接种异常反应知晓率的Meta分析[J].预防医学,2021,33(3):250-254.
YAN B,ZHOU Q Y,ZHENG X H,et al.Awareness rate of adverse events following immunization among Chinese parents:a meta-analysis[J].Prev Med,2021,33(3):250-254.
[10] 杜哲群,胡洁,沈国初,等.嘉兴市8月龄儿童接种MMR、MR疫苗疑似预防接种异常反应监测结果[J].预防医学,2020,32(11):1086-1090.
DU Z Q,HU J,SHEN G C,et al.Adverse events following immunization of measles,mumps and rubella,or measles and rubella combined attenuated live vaccine among 8-month-old children in Jiaxing[J].Prev Med,2020,32(11):1086-1090.
[11] 王晓娟,赵雄,曹琰.联合疫苗的发展及相关问题探讨[J].中国药品标准,2022,23(1):46-50.
WANG X J,ZHAO X,CAO Y.Progress and related problems on combined vaccine[J].Drug Stand China,2022,23(1):46-50.
[12] VERITY C M,GREENWOOD R,GOLDING J.Long-term intellectual and behavioral outcomes of children with febrile convulsions[J].N Engl J Med,1998,338(24):1723-1728.
[13] JACOBSEN J S,ACKERSON K B,SY S L,et al.Observational safety study of febrile convulsion following first dose MMRV vaccination in a managed care setting[J].Vaccine,2009,27(34):4656-4661. |
|
|
|
