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| Association between arsenic exposure and spontaneous abortion: a review of epidemiological studies |
| PEI Hang, MA Zhibin, LIAO Jiyun, YANG Chen, LIU Xingrong
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| School of Medicine, Lanzhou University, Lanzhou, Gansu 730000, China |
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Abstract Arsenic and arsenic compounds have been listed as one of the toxic and harmful environment pollutants, and drinking, seafood intake, use of skincare products and inhalation of tobacco smoke are main routes of exposure to human arsenic exposure. The adverse effects of arsenic on pregnant outcomes have been paid much attention. Prenatal exposure to high-level arsenic has been found to increase the risk of spontaneous abortion among pregnant women. Based on national and international epidemiological studies on the correlation between arsenic exposure and spontaneous abortion during the period between 1992 and 2020, we review the association between arsenic exposure and spontaneous abortion and describe the mechanisms underlying spontaneous abortion caused by arsenic exposure, so as to provide insights into early prevention of spontaneous abortion.
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Received: 09 June 2022
Revised: 17 July 2022
Published: 30 September 2022
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[1] CONCHA G,VOGLER G,LEZCANO D,et al.Exposure to inorganic arsenic metabolites during early human development[J].Toxicol Sci,1998,44(2):185-190.
[2] HALL M,GAMBLE M,SLAVKOVICH V,et al.Determinants of arsenic metabolism:blood arsenic metabolites,plasma folate,cobalamin,and homocysteine concentrations in maternal-newborn pairs[J].Environ Health Perspect,2007,115(10):1503-1509.
[3] MILTON A H,HUSSAIN S,AKTER S,et al.A review of the effects of chronic arsenic exposure on adverse pregnancy outcomes[J/OL].Int J Environ Res Public Health,2017,14(6)[2022-07-17].https://doi.org/10.3390/ijerph14060556.
[4] 徐文珍,罗亚翠,张海君,等.微波消解-电感耦合等离子体质谱法测定胎盘组织17种元素[J].预防医学,2022,34(5):534-539.
XU W Z,LUO Y C,ZHANG H J,et al.Determination of 17 elements in placenta by microwave digestion-inductively coupled plasma mass spectrometry[J].Prev Med,2022,34(5):534-539.
[5] RAHMAN A,PERSSON L,NERMELL B,et al.Arsenic exposure and risk of spontaneous abortion,stillbirth,and infant mortality[J].Epidemiology,2010,21(6):797-804.
[6] QUANSAH R,ARMAH F A,ESSUMANG D K,et al.Association of arsenic with adverse pregnancy outcomes/infant mortality:a systematic review and meta-analysis[J].Environ Health Perspect,2015,123(5):412-421.
[7] 朱泓,曹露露,杨祖菁.妊娠期重金属暴露水平对母儿的影响及相关因素分析[J].中国医师杂志,2010,12(11):1485-1489.
ZHU H,CAO L L,YANG Z J.The impact of heavy metal exposure on mother-infant health during pregnancy and its related factors[J].Chin J Med Doct,2010,12(11):1485-1489.
[8] 廖雅芬,叶坚,杨业洲.肇庆市城市饮用水化学物质健康风险评估[J].预防医学,2021,33(9):951-954.
LIAO Y F,YE J,YANG Y Z.Health risk assessment on chemicals in urban drinking water in Zhaoqing[J].Prev Med,2021,33(9):951-954.
[9] 覃利梅,苏旭.尿砷检测方法的应用进展[J].中国临床新医学,2013,6(4):387-390.
QIN L M,SU X.The method overview of determination of arsenic in urine[J].Chin J New Clin Med,2013,6(4):387-390.
[10] 丁娜娜. 职业性砷暴露工人尿砷水平及影响因素的研究[D].昆明:昆明医科大学,2016.
DING N N.Study of urinary arsenic and influencing factors in workers of arsenic exposure[D].Kunming:Kunming Medical University,2016.
[11] 李园园. 重金属、邻苯二甲酸酯内暴露水平及氧化应激与不明原因复发性自然流产关系研究[D].北京:中国疾病预防控制中心,2019.
LI Y Y.Study on association of heavy metals and phthalates exposure and oxidative stress with unexplained recurrent spontaneous abortion[D].Beijing:Chinese Center for Disease Control and Prevention,2019.
[12] WANG R,ZHANG L,CHEN Y,et al.Elevated non-essential metals and the disordered metabolism of essential metals are associated to abnormal pregnancy with spontaneous abortion[J/OL].Environ Int,2020,144 [2022-07-17].https://doi.org/10.1016/j.envint.2020.106061.
[13] 谢利傲,姚鉴玲,朱天垣,等.血清中铜、锌、镍、镉、锰等微量元素对稽留流产影响的研究[J].中华疾病控制杂志,2020,24(4):489-492.
XIE L A,YAO J L,ZHU T Y,et al.Study on the effect of trace elements such as copper,zinc,nickel,iron and manganese in serum on the missed abortion[J].Chin J Dis Control Prev,2020,24(4):489-492.
[14] SEN J,CHAUDHURI A B.Arsenic exposure through drinking water and its effect on pregnancy outcome in Bengali women[J].Arh Hig Rada Toksikol,2008,59(4):271-275.
[15] BÖRZSÖNYI M,BERECZKY A,RUDNAI P,et al.Epidemiological studies on human subjects exposed to arsenic in drinking water in southeast Hungary[J].Arch Toxicol,1992,66(1):77-78.
[16] AHMAD S A,SAYED M H,BARUA S,et al.Arsenic in drinking water and pregnancy outcomes[J].Environ Health Perspect,2001,109(6):629-631.
[17] MILTON A H,SMITH W,RAHMAN B,et al.Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh[J].Epidemiology,2005,16(1):82-86.
[18] VON EHRENSTEIN O S,GUHA MAZUMDER D N,HIRA-SMITH M,et al.Pregnancy outcomes,infant mortality,and arsenic in drinking water in West Bengal,India[J].Am J Epidemiol,2006,163(7):662-669.
[19] BLOOM M S,NEAMTIU I A,SURDU S,et al.Consumption of low-moderate level arsenic contaminated water does not increase spontaneous pregnancy loss:a case control study[J/OL].Environ Health,2014,13 [2022-07-17].https://doi.org/10.1186/1476-069X-13-81.
[20] 李园园,陈素文,赵峰,等.砷与不明原因复发性自然流产关联的病例对照研究[J].中华预防医学杂志,2019,53(5):470-474.
LI Y Y,CHEN S W,ZHAO F,et al.Association of arsenic with unexplained recurrent spontaneous abortion: a case-control study[J].Chin J Prev Med,2019,53(5):470-474.
[21] RAHMAN A,VAHTER M,EKSTROME C,et al.Association of arsenic exposure during pregnancy with fetal loss and infant death:a cohort study in Bangladesh[J].Am J Epidemiol,2007,165(12):1389-1396.
[22] SHIH Y H,ISLAM T,HORE S K,et al.Associations between prenatal arsenic exposure with adverse pregnancy outcome and child mortality[J].Environ Res,2017,158:456-461.
[23] VAHTER M E,LI L,NEMELL B,et al.Arsenic exposure in pregnancy:a population-based study in Matlab,Bangladesh[J].J Health Popul Nutr,2006,24(2):236-245.
[24] LINBERG A L,EKSTRÖM E C,NERMELL B,et al.Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh[J].Environ Res,2008,106(1):110-120.
[25] AHMED S M,NOBLE B N,JOYA S A,et al.A prospective cohort study examining the associations of maternal arsenic exposure with fetal loss and neonatal mortality[J].Am J Epidemiol,2019,188(2):347-354.
[26] NYANXA E C,BEMIER F P,MANYAMA M,et al.Maternal exposure to arsenic and mercury in small-scale gold mining areas of Northern Tanzania[J].Environ Res,2019,173:432-442.
[27] NYANZA E C,DEWEY D,MANYAMA M,et al.Maternal exposure to arsenic and mercury and associated risk of adverse birth outcomes in small-scale gold mining communities in Northern Tanzania[J/OL].Environ Int,2020,137[2022-07-17].https://doi.org/10.1016/j.envint.2019.105450.
[28] RAHMAN A,KUMARATHASAN P,GOMES J.Infant and mother related outcomes from exposure to metals with endocrine disrupting properties during pregnancy[J].Sci Total Environ,2016,569/570:1022-1031.
[29] FLORA S J.Arsenic-induced oxidative stress and its reversibility[J].Free Radic Biol Med,2011,51(2):257-281.
[30] 欧婕. 孕妇重金属暴露对早期妊娠结局的影响及其机制研究[D].北京:北京协和医学院,2020.
OU J.Exploration of effects of heavy metals on early pregnancy outcomes in pregnant women and its mechanism[D].Beijing:Peking Union Medical College,2020.
[31] ZHANG T C,SCHMITT M T,MUMFORD J L.Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro[J].Carcinogenesis,2003,24(11):1811-1817.
[32] WAALKES M P,LIU J,CHEN H,et al.Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero[J].J Natl Cancer Inst,2004,96(6):466-474.
[33] BEKAERT S,DERRADJI H,BAATOUT S.Telomere biology in mammalian germ cells and during development[J].Dev Biol,2004,274(1):15-30.
[34] WALKER W H.Testosterone signaling and the regulation of spermatogenesis[J].Spermatogenesis,2011,1(2):116-120.
[35] 徐维海,骆文龙,张岭,等.不育症患者精浆金属雌激素与精子质量的关联[J].预防医学,2021,33(7):679-684.
XU W H,LUO W L,ZHANG L,et al.The association between metalloestrogens in seminal plasma and sperm quality in infertile patients[J].Prev Med,2021,33(7):679-684.
[36] YANG M H,CHANG K J,ZHENG J C,et al.Anti-angiogenic effect of arsenic trioxide in lung cancer via inhibition of endothelial cell migration,proliferation and tube formation[J].Oncol Lett,2017,14(3):3103-3109.
[37] CHIOU T J,CHU S T,TZENG W F,et al.Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway[J].Chem Res Toxicol,2008,21(8):1562-1569.
[38] CESAR R S,IRMA G C,SERGIO Z,et al.Lipid metabolism alterations in a rat model of chronic and intergenerational exposure to arsenic[J/OL].Biomed Res Int,2019[2022-07-17].https://doi.org/10.1155/2019/4978018.
[39] MICHALAKIS K,MINTZIORI G,KAPRARA A,et al.The complex interaction between obesity,metabolic syndrome and reproductive axis:a narrative review[J].Metabolism,2013,62(4):457-478. |
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