注意缺陷多动障碍不同表现型的反应时低频振幅研究

doi:10.19485/j.cnki.issn2096-5087.2022.07.020

Preventive Medicine

2022, Vol. 34

Issue (7): 747-750,755 DOI: 10.19485/j.cnki.issn2096-5087.2022.07.020

Disease Control

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Amplitude of low-frequency fluctuations of behavioral characteristics in different phenotypes of attention deficit hyperactivity disorder

WANG Qipeng^1,2,3, CAO Longfei^2,3, ZHANG Hang^2,3, FANG Yantong^2,3, YE Baojuan¹

1. School of Psychology, Jiangxi Normal University, Nanchang, Jiangxi 330000, China;
2. Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015;
3. Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment, Hangzhou, Zhejiang 310015, China

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Abstract Objective To investigate the difference in behavioral characteristics among different phenotypes of attention deficit hyperactivity disorder (ADHD) using amplitude of low-frequency fluctuation (ALFF), so as to provide insights into clinical differentiation of behavioral characteristics among different phenotypes of ADHD. Methods The children with ADHD admitted to The Affiliated Hospital of Hangzhou Normal University were enrolled and classified into the inattentive type (ADHD-I), hyperactive/impulsive type (ADHD-HI) and combined type (ADHD-C). The reaction time (RT) was measured using integrated visual and auditory continuous performance test, and the mean (RT-mean) and standard deviation of RT (RT-SD) were estimated. In addition, the ALFF was calculated at 0.010 to 0.027, 0.027 to 0.073, 0.073 to 0.167 Hz, and the difference of ALFF was compared among children with different types of ADHD. Results A total of 107 children with ADHD were enrolled, including 95 boys and 12 girls, with a mean age of (8.89±1.93) years. There were 69 children with ADHD-I, 8 children with ADHD-HI and 30 children with ADHD-C. The RT-SD was significantly higher among children with ADHD-C than among children with ADHD-I [(126.003±51.619) ms vs. (97.720±45.302) ms; P=0.007]; however, there was no significant difference in RT-mean among children with various ADHD phenotypes (F=1.386, P=0.255). There was an interaction between frequency and ADHD phenotypes (F=2.754, P=0.032), and the ALFF was significantly higher among children with ADHD-C than among children with ADHD-I at 0.010 to 0.027 [(5 590.567±231.595) ms vs. (4 694.001±154.397) ms; P=0.002] and 0.073 to 0.167 Hz [(4 312.609±174.709) ms vs. (3 690.805±116.473) ms; P=0.005]. Conclusions The ALFF varies in ADHD phenotypes, and there is a frequency-specific difference.

Key words： attention deficit hyperactivity disorder phenotype behavioral characteristics reaction time amplitude of low-frequency fluctuation

Received: 12 April 2022 Revised: 06 June 2022 Published: 19 July 2022

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	WANG Qipeng
	CAO Longfei
	ZHANG Hang
	FANG Yantong
	YE Baojuan

Cite this article:

WANG Qipeng,CAO Longfei,ZHANG Hang, et al. Amplitude of low-frequency fluctuations of behavioral characteristics in different phenotypes of attention deficit hyperactivity disorder[J]. Preventive Medicine, 2022, 34(7): 747-750,755.

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http://www.zjyfyxzz.com/EN/10.19485/j.cnki.issn2096-5087.2022.07.020 OR http://www.zjyfyxzz.com/EN/Y2022/V34/I7/747

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