|
|
|
| Research progress of antibiotic resistance genes in environment |
| ZHU Guangping, XUE Chenchen, FAN Hongliang, WU Nanxiang
|
| Hangzhou Medical College, Hangzhou, Zhejiang 310013, China |
|
|
|
|
Abstract Recent years have witnessed extensive drug resistance of environmental microorganisms due to the abuse of antibiotics. The emergence and global spread of antibiotic resistance genes (ARGs) has led to great potential harms to human health and environment stability. The ARGs in the environment mainly come from the evolution of microorganisms and horizontal gene transfer between strains, and are widely distributed in water, soil and atmosphere. The transmission of ARGs is affected by residual antibiotics, heavy metals and organic compounds in the environment. The existing detection methods for ARGs include the detection of phenotype and genotype of drug-resistant bacteria. The methods based on polymerase chain reaction have been developed, while metagenomics will open another door for more efficient and accurate detection of ARGs. This paper reviews the studies into the source, outcome, transmission, influencing factors and detection of ARGs, in order to provide reference for the management, control and prevention of ARGs in the environment.
|
|
Received: 05 June 2020
Revised: 29 July 2020
Published: 09 November 2020
|
|
|
|
|
|
[1] RYSZ M,ALVAREZ P J.Amplification and attenuation of tetracycline resistance in soil bacteria:aquifer column experiments[J]. Water Res,2004,38(17):3705-3712.
[2] KENNEDY D.Time to deal with antibiotics[J].Science,2013,342(6160):777.
[3] PRUDEN A,PEI R T,STORTEBOOM H,et al.Antibiotic resistance genes as emerging contaminants: studies in Northern Colorado[J]. Environ Sci Technol,2007,40(23):7445-7450.
[4] 徐冰洁,罗义,周启星,等. 抗生素抗性基因在环境中的来源、传播扩散及生态风险[J].环境化学,2010,29(2):169-178.
[5] 苏志国,张衍,代天娇,等. 环境中抗生素抗性基因与Ⅰ型整合子的研究进展[J].微生物学通报,2018,45(10):153-169.
[6] ZHANG S,YANG G,HOU S,et al.Distribution of ARGs and MGEs among glacial soil,permafrost,and sediment using metagenomic analysis[J].Environ pollut,2018,234:339-346.
[7] CHEN B,YUAN K,CHEN X,et al.Metagenomic analysis revealing antibiotic resistance genes (ARGs) and their genetic compartments in the Tibetan environment[J].Environ Sci Technol,2016,50(13):6670-6679.
[8] TOTH M,SMITH C,FRASE H,et al.An antibiotic-resistance enzyme from a deep-sea bacterium[J].J Am Chem Soc,2010,132(2):816-823.
[9] BROWN M G,BALKWILL D L.Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface[J].Microb Ecol,2009,57(3):484-493.
[10] ZHANG Q Q,YING G G,PAN C G,et al.Comprehensive evaluation of antibiotics emission and fate in the river basins of China:source analysis,multimedia modeling,and linkage to bacterial resistance[J].Environ Sci Technol,2015,49(11):6772-6782.
[11] JIA J,GUAN Y,CHENG M,et al.Occurrence and distribution of antibiotics and antibiotic resistance genes in Ba River,China[J].Sci Total Environ,2018,642:1136-1144.
[12] YUAN J,NI M,LIU M,et al.Occurrence of antibiotics and antibiotic resistance genes in a typical estuary aquaculture region of Hangzhou Bay,China[J].Mar Pollut Bull,2019,138:376-384.
[13] QIU W,SUN J,FANG M,et al.Occurrence of antibiotics in the main rivers of Shenzhen,China:association with antibiotic resistance genes and microbial community[J].Sci Total Environ,2019,653:334-341.
[14] HUANG H,ZENG S,DONG X,et al.Diverse and abundant antibiotics and antibiotic resistance genes in an urban water system[J].J Environ Manage,2019,231:494-503.
[15] 智建辉,宋晟宇,段雅欣. 城镇污水处理厂进水抗生素抗性基因的控制与削减研究[J].水资源开发与管理,2018,34(11):28-33.
[16] BOUGNOM B P,THIELE-BRUHN S,RICCI V,et al.Raw wastewater irrigation for urban agriculture in three African cities increases the abundance of transferable antibiotic resistance genes in soil,including those encoding extended spectrumβ-lactamases(ESBLs)[J/OL].Sci Total Environ,2020,698(2020-01-01)[2020-07-29]. https://pubmed.ncbi.nlm.nih.gov/31505362.
[17] ZHAO X,WANG J,ZHU L,et al.Environmental analysis of typical antibiotic-resistant bacteria and ARGs in farmland soil chronically fertilized with chicken manure[J].Sci Total Environ,2017,593:10-17.
[18] LEE J,SHIN S G,JANG H M,et al.Characterization of antibiotic resistance genes in representative organic solid wastes:food waste-recycling wastewater,manure,and sewage sludge[J].Sci Total Environ,2017,579:1692-1698.
[19] LIU X,YANG S,WANG Y,et al.Metagenomic analysis of antibiotic resistance genes (ARGs) during refuse decomposition[J].Sci Total Environ,2018,634:1231-1237.
[20] 乔博超,吴楠,杨静慧,等. 环境中抗生素抗性基因的来源,分布及控制对策[J].天津农林科技,2017,260(6):16-18.
[21] 夏雨荷,谭莉,徐敏,等.武汉市某医院空调过滤网积尘中抗生素抗性基因污染状况[J].卫生研究,2019,48(4):583-588.
[22] HU J,ZHAO F,ZHANG X X,et al.Metagenomic profiling of ARGs in airborne particulate matters during a severe smog event[J].Sci Total Environ,2018,615:1332-1340.
[23] ZHU D,CHEN Q L,LI H,et al.Land use influences antibiotic resistance in the microbiome of soil collembolans Orchesellides sinensis[J].Environ Sci Technol,2018,52(24):14088-14098.
[24] DING J,ZHU D,HONG B,et al.Long-term application of organic fertilization causes the accumulation of antibiotic resistome in earthworm gut microbiota[J].Environ Int,2019,124:145-152.
[25] FANG T,WANG H,CUI Q,et al.Diversity of potential antibiotic-resistant bacterial pathogens and the effect of suspended particles on the spread of antibiotic resistance in urban recreational water[J].Water Res,2018,145:541-551.
[26] WANG S,XUE N,LI W,et al.Selectively enrichment of antibiotics and ARGs by microplastics in river,estuary and marine waters[J/OL].Sci Total Environ,2020,708(2020-03-15)[2020-07-29].https://pubmed.ncbi.nlm.nih.gov/31796269.
[27] XIE J,JIN L,HE T,et al.Bacteria and antibiotic resistance genes(ARGs)in PM2.5 from China:implications for human exposure[J].Environ Sci Technol,2018,53(2):963-972.
[28] 张宁,李淼,刘翔. 土壤中抗生素抗性基因的分布及迁移转化[J].中国环境科学,2018,38(7):2609-2617.
[29] 黄锦岭. 水平基因转移及其发生机制[J].科学通报,2017,62(12):29-33.
[30] GUO J,LI J,CHEN H,et al.Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements[J].Water Res,2017,123:468-478.
[31] 杨凤霞,毛大庆,罗义,等.环境中抗生素抗性基因的水平传播扩散[J].应用生态学报,2013,24(10):2993-3002.
[32] 汪庆,罗义,崔玉晓,等. 离子液体[BMIm][PF6]增强抗性质粒RP4介导的接合转移基因mRNA的表达水平[J].生态毒理学报,2017,12(3):273-281.
[33] LU J,WANG Y,JIN M,et al.Both silver ions and silver nanoparticles facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes[J/OL].Water Res,2020,169(2020-02-01)[2020-07-29]. https://pubmed.ncbi.nlm.nih.gov/31783256.
[34] 魏媛媛. 季铵化合物对抗生素抗性基因传播扩散的影响和机理探究[D].杭州:浙江大学,2018.
[35] CALERO-CÁCERES W,BALCÁZAR J L. Antibiotic resistance genes in bacteriophages from diverse marine habitats[J].Sci Total Environ,2019,654:452-455.
[36] PELEG A Y,SEIFERT H,PATERSON D L.Acinetobacter baumannii:emergence of a successful pathogen[J].Clin Microbiol Rev,2008,21(3):538-582.
[37] 韩雪. 纳米TiO2促进噬菌体介导的抗生素抗性基因水平转移机制研究[D]. 镇江:江苏大学,2019.
[38] KNAPP C W,ZHANG W,STURM B S M,et al.Differential fate of erythromycin and beta-lactam resistance genes from swine lagoon waste under different aquatic conditions[J].Environ Pollut,2010,158(5):1506-1512.
[39] DUARTE D J,OLDENKAMP R,RAGAS A M J. Modelling environmental antibiotic-resistance gene abundance:a meta-analysis[J].Sci Total Environ,2019,659:335-341.
[40] PHIMISTER E G,ARIAS C A,MURRAY B E.A new antibiotic and the evolution of resistance[J].N Engl J Med,2015,372(12):1168-1170.
[41] REDDY B,DUBEY S K.River Ganges water as reservoir of microbes with antibiotic and metal ion resistance genes:high throughput metagenomic approach[J].Environ Pollut,2018,246:443-451.
[42] ZHAO Y,COCERVA T,COX S,et al.Evidence for co-selection of antibiotic resistance genes and mobile genetic elements in metal polluted urban soils[J].Sci Total Environ,2019,656:512-520.
[43] ZHANG Y,GU A Z,CEN T,et al.Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment[J].Environ Pollut,2018,237:74-82.
[44] LU J,JIN M,NGUYEN S H,et al.Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation[J].Environ Int,2018,118:257-265.
[45] GUO H,GU J,WANG X,et al.Key role of cyromazine in the distribution of antibiotic resistance genes and bacterial community variation in aerobic composting[J].Bioresour Technol,2019,274:418-424.
[46] ZHANG Q Q,TIAN G M,JIN R C.The occurrence,maintenance,and proliferation of antibiotic resistance genes(ARGs)in the environment:influencing factors,mechanisms,and elimination strategies[J].Appl Microbiol Biotechnol,2018,102(19):8261-8274.
[47] TUMAH H N.Bacterial biocide resistance[J].J Chemother,2009,21(1):5-15.
[48] SUN Y,QIU T,GAO M,et al.Inorganic and organic fertilizers application enhanced antibiotic resistome in greenhouse soils growing vegetables[J].Ecotoxicol Environ Saf,2019,179:24-30.
[49] LIN H,CHAPMAN S J,FREITAG T E,et al.Fate of tetracycline and sulfonamide resistance genes in a grassland soil amended with different organic fertilizers[J]. Ecotoxicol Environ Saf,2018,170:39-46.
[50] ZHOU Z M,YAO H Y. Effects of composting different types of organic fertilizer on the microbial community structure and antibiotic resistance genes[J/OL]. Microorganisms,2020,8(2020-02-17)[2020-07-29].https://pubmed.ncbi.nlm.nih.gov/32079314.
[51] WANG G G,ZHOU S H,HAN X K,et al.Occurrence,distribution,and source track of antibiotics and antibiotic resistance genes in the main rivers of Chongqing City,Southwest China[J/OL]. J Hazard Mater,2020,389(2020-05-05)[2020-07-29].https://pubmed.ncbi.nlm.nih.gov/31978820.
[52] ZHENG W L,HUYAN J Q,TIAN Z,et al.Clinical class 1 integron-integrase gene-a promising indicator to monitor the abundance and elimination of antibiotic resistance genes in an urban wastewater treatment plant[J/OL].Environ Int(2019-12-12)[2020-07-29]. https://pubmed.ncbi.nlm.nih.gov/31838265.
[53] LI M M,RAY P,TEETS C,et al.Short communication:increasing temperature and pH can facilitate reductions of cephapirin and antibiotic resistance genes in dairy manure slurries[J].J Dairy Sci,2020,103(3):2877-2882.
[54] CHEN X F,YIN H L,LI G Y,et al.Antibiotic-resistance gene transfer in antibiotic-resistance bacteria under different light irradiation:implications from oxidative stress and gene expression[J].Water Res,2018,149:282-291.
[55] 车洁,陈霞,李娟,等.细菌耐药性检测技术方法及其应用[J].疾病监测,2017,32(9):757-763.
[56] WASEEM H,JAMEEL S,ALI J,et al.Contributions and challenges of high throughput qPCR for determining antimicrobial resistance in the environment:a critical review[J].Molecules,2019(2019-01-03)[2020-07-29].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337382.
[57] 胡海燕,刘慧敏,孟璐,等. 宏基因组学在微生物抗生素抗性基因检测中的应用[J].微生物学通报,2019,46(11):3110-3123. |
|
|
|
