[1] ABRALLAM C,CHO J.Inflammatory bowel disease[J]. N Engl J Med,2009,361(21):2066-2078. [2] AHUJA V,TANDON R K.Inflammatory bowel disease in the Asia-Pacific area:a comparison with developed countries and regional differences[J]. Dig Dis,2010,11(3):134-147. [3] SCHIRBEL A,FIOCCHI C.Inflammatory bowel disease:established and evolving considerations on its etiopathogenesis and therapy[J]. Dig Dis,2010,11(5):266-276. [4] ENGEL M A,NEURATH M F.New pathophysiological insights and modern treatment of IBD[J]. Gastroenterol,2010,45(6):571-583. [5] ALLOCCA M,JOVANI M,FIORINO G,et al.Anti-IL-6 treatment for inflammatory bowel diseases:next cytokine,next target[J]. Curr Drug Targets,2013,14(12):1508-1521. [6] GOEL A,KUNNUMAKKARA A B,AGGARWAL B B.Curcumin as "curecumin":from kitchen to clinic[J]. Biochem Pharmacol,2008,75(4):787-809. [7] SIKORA E,SCAPAGNINI G,BARBAGALLO M.Curcumin,inflammation,ageing and age-related diseases[J]. Immunity & Ageing,2010,7(1):1. [8] REUTER S,EIFES S,DICATO M,et al.Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells[J]. Biochemical Pharmacology,2008,76(11):1340-1351. [9] LIU L,LIU Y L,LIU G X,et al.Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway[J]. Int Immunopharmacol,2013,17(2):314-320. [10] ARAFA H M,HEMEIDA R A,EL-BAHRAWY A I,et al. Prophylactic role of curcumin in dextran sulfate sodium(DSS)-induced ulcerative colitis murine model[J]. Food Chem Toxicol,2009,47(6):1311-1317. [11] EPSTEIN J,DOCENA G,MACDONALD T T,et al.Curcumin suppresses p38 mitogen-activated protein kinase activation,reduces IL-1β and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease[J]. Br J Nutr,2010,103(6):824-832. [12] LUBBAD A,ORIOWO M A,KHAN I.Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis[J]. Molecular & Cellular Biochemistry,2009,322(1- 2):127-135. [13] MORRIS G P,BECK P L,HERRIDGE M S,et al.Hapten-induced model of chronic inflammation and ulceration in the rat colon[J]. Gastroenterology,1989,96(3):795-803. [14] PAIOTTI A P,RIBEIRO D A,SILVA R M,et al.Effect of CO4X-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNPS-induced colitis in Wistar rats[J]. Mol Histol,2012,43(3):307-317. [15] DIELEMAN L A,PALMEN M J,AKOL H,et al.Chronic experimental colitis induced by dextran sulphate sodium(DSS)is characterized by Th1 and Th2 cytokines[J]. Clin Exp Immunol,1998, 114(3):385-391. [16] NDUJAR I A,RIOS J L,GINER R M,et al.Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/c mice[J]. Evid Based Complement Alternat Med,2012(38):271606. [17] WINE E,MACK D R,HYAMS J,et al.Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis[J]. J Crohns Colitis,2013,7(1):916-922. [18] VAN K C,BELAICHE J,LOUIS E.Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission[J]. Int J Colorectal Dis,2000,15(4):206-210. [19] FUJINO S,ANDOH A,BAMBA S,et al.Increased expresion of interleukin17 in inflammatory bowel disease[J]. Gut,2003,52(1):65-70. [20] ATREYA R,ATREYA I,NEURATH M F,et al.Novel signal transduction pathways:analysis of Stat-3 and Rac-1 signaling in infammatory bowel disease[J]. Annals of the New York Academy of Sciences, 2010,1072(1):98-113. [21] EASTAFF-LEUNG N,MABARRACK N,BARBOUR A,et al.FOXP3+regulatory T cells,Th17 effector cells,and cytokine environment in inflammatory bowel disease[J]. J Clin Immunol,2010,30(1):80-89. [22] SANSONE P,BROMBERG J.Targeting the interleukin-6/Jak/Stat pathway in human malignancie[J]. J Clin Oncol,2012,30(9):1005. [23] ZHOU L,LITTAN D R.Transcriptional regulatory networks in Th17 cell differentiation[J]. Curr Opin Immtmol,2009,21(2):146-152. [24] MUCIDA D,PARK Y,KIM G,et al.Reciprocal Th17 and regulatory T cell differentiation mediated by retinoic acid[J]. Science,2007,317(5835):256-260. |