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| An observation on the long-term efficacy of recombinant hepatitis B vaccines among the newborns |
| DONG Xiao-lian, TANG Zhi-feng, WANG Xue-cai, CHEN Ying-feng, CHEN Sheng-yu, WANG Xiao-li, FAN Jian-liang, ZHENG Ying-jie
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| The Center for Disease Control and Prevention of Deqing County,Huzhou,Zhejiang,313200,China |
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Abstract Objective evaluate the long-term efficacy of the recombinant hepatitis B vaccines （HBV）among the newborns with vaccination at birth. Methods During 1996-1997,135 newborns were selected from Deqing according to the inclusion criterion. They were divided into 2 groups: a group of 35 newborns whose mother was HBsAg positive） and a group of 100 newbornswhose mother was HBsAg negative. All 135 newborns routinely received 3 doses of yeast -derived hepatitis B vaccines （i.e. the first dose at birth,the second dose at 1 month old,and the third dose at 6 months old）. Serological markers to HBV were repeatedly assessed at 3 follow-up stages （i.e. the first follow-up at 12 months,the second follow-up at 2010,the third follow-up at 2012）. Results Participants remained in the study at 3 follow-upstages were 123 （91.11%）,95（70.37%）and 46（34.07%）respectively. Participants' serum HBsAg were negative at all 3 follow-up stages. Among participants whose mothers were HBsAg positive,3 participants were found to be HBcAb positive in 2010,and no new HBcAb positive participants were found in 2012. The rates of HBsAb positive at 3 follow-up stages were 88.89%,81.48%,and 80.00% respectively. The HBsAb geometric mean concentrations （GMCs） of participants at their 12 months old were significantly positively associated with those in 2010 and those in 2012（P<0.05）. Among participants whose mothers were HBsAg negative,no HBcAb positive participants were found. The rates of HBsAb positive at 3 follow-up stages were 91.18%,54.41%,and 52.78% respectively. No correlation was found among HBsAb GMCs of participants at 12 months old,in 2010 and in 2012. No correlation was found between boost vaccination and the rate of HBsAg positive,after adjustment of the HBsAg status of their mothers. Conclusion The efficacy of the yeast-derived HBV could sustain for at least 13-15 years,and the general population do not need booster immunization. After the 3-dose immunization,the HBsAb levels of the healthy mothers' 12-months-old children were related to those of their adolescence.
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Received: 27 September 2016
Revised: 13 December 2016
Published: 27 October 2017
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