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| Food intake and atherosclerosis: a Mendelian randomization study |
| LIU Wei, LIN Quan, FAN Zongjing, CUI Jie, WU Yang
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| Department of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Objective To examine the causal relationship between food intake and atherosclerosis using two-sample Mendelian randomization (MR) approach, so as to provide the reference for the prevention of atherosclerosis. Methods Data of 16 types of food (grains, vegetables, fruits, meats, etc.) and 4 types of atherosclerosis (coronary atherosclerosis, cerebral atherosclerosis, peripheral atherosclerosis and other atherosclerosis) was collected through IEU OpenGWAS database, with food data comprising approximately 500 000 subjects and 9 851 867 SNPs and atherosclerosis data comprising approximately 200 000 subjects and 16 380 447 SNPs. The causal relationship was analyzed using inverse-variance weighted (IVW) method with food as the exposure variable and atherosclerosis as the outcome variable. Sensitivity analysis was performed using funnel plots and leave-one-out. Results Dried fruit intake was associated with decreased risks of peripheral atherosclerosis (OR=0.195, 95%CI: 0.082-0.466) and other atherosclerosis (OR=0.208, 95%CI: 0.095-0.452), and cheese intake was associated with decreased risk of peripheral atherosclerosis (OR=0.575, 95%CI: 0.380-0.870). Coffee intake was associated with increased risk of coronary atherosclerosis (OR=1.645, 95%CI: 1.099-2.462), and alcohol intake was associated with increased risk of other atherosclerosis (OR=1.269, 95%CI: 1.032-1.561). There was no statistically significant association between 16 types of food and cerebral atherosclerosis. No horizontal pleiotropy was found, no single SNP had significant impact on the overall estimated value, and the funnel plots did not show significant bias. Conclusion Dried fruit and cheese intake are protective factors for atherosclerosis, while coffee and alcohol intake are risk factors for atherosclerosis.
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Received: 08 February 2024
Revised: 27 April 2024
Published: 20 June 2024
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[1] LIBBY P,BURING J E,BADIMON L,et al.Atherosclerosis[J/OL].Nat Rev Dis Primers,2019,5[2024-04-27].https://doi.org/10.1038/s41572-019-0106-z.
[2] FOROUHI N G,KRAUSS R M,TAUBES G,et al.Dietary fat and cardio metabolic health:evidence,controversies,and consensus for guidance[J/OL].BMJ,2018,361[2024-04-27].https://doi.org/10.1136/bmj.k2139.
[3] KEY T J,APPLEBY P N,BRADBURY K E,et al.Consumption of meat,fish,dairy products,and eggs and risk of ischemic heart disease[J].Circulation,2019,139(25):2835-2845.
[4] BURGESS S,DAVEY SMITH G,DAVIES N M,et al.Guidelines for performing Mendelian randomization investigations:update for summer2023[J/OL].Wellcome Open Res,2019,4[2024-04-27].https://doi.org/10.12688/wellcomeopenres.15555.3.
[5] ZHOU R,ZHANG L,SUN Y,et al.Causal associations between dietary habits and chronic pain:a two-sample Mendelian randomization study[J/OL].Nutrients,2023,15[2024-04-27].https://doi.org/10.3390/nu15173709.
[6] RICCARDI G,GIOSUÈ A,CALABRESE I,et al.Dietary recommendations for prevention of atherosclerosis[J].Cardiovasc Res,2022,118(5):1188-1204.
[7] EMDIN C A,KHERA A V,KATHIRESAN S.Mendelian randomization[J].JAMA,2017,318(19):1925-1926.
[8] SUDLOW C,GALLACHER J,ALLEN N,et al.UK biobank:an open access resource for identifying the causes of a wide range of complex diseases of middle and old age[J/OL].PLoS Med,2015,12[2024-04-27].https://doi.org/10.1371/journal.pmed.1001779.
[9] MACHIELA M J,CHANOCK S J.LDlink:a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants[J].Bioinformatics,2015,31(21):3555-3557.
[10] BURGESS S,THOMPSON S G,CRP CHD Genetics Collaboration.Avoiding bias from weak instruments in Mendelian randomization studies[J].Int J Epidemiol,2011,40(3):755-764.
[11] 高亚南,徐涯鑫,朱宇倩,等.克罗恩病与衰弱的双向孟德尔随机化研究[J].预防医学,2023,35(11):943-947.
[12] BURGESS S,BOWDEN J,FALL T,et al.Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants[J].Epidemiology,2017,28(1):30-42.
[13] BOWDEN J,DAVEY SMITH G,BURGESS S.Mendelian randomization with invalid instruments:effect estimation and bias detection through Egger regression[J].Int J Epidemiol,2015,44(2):512-525.
[14] MOZAFFARIAN D,WU J.Flavonoids,dairy foods,and cardiovascular and metabolic health:a review of emerging biologic pathways[J].Circ Res,2018,122(2):369-384.
[15] ZHANG K,CHEN X G,ZHANG L,et al.Fermented dairy foods intake and risk of cardiovascular diseases:a meta-analysis of cohort studies[J].Crit Rev Food Sci Nutr,2020,60(7):1189-1194.
[16] PUGLISI M J,VAISHNAV U,SHRESTHA S,et al.Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines[J/OL].Lipids Health Dis,2008,7[2024-04-27].https://doi.org/10.1186/1476-511X-7-14.
[17] BAYS H,WEITER K,ANDERSON J.A randomized study of raisins versus alternative snacks on glycemic control and other cardiovascular risk factors in patients with type 2 diabetes mellitus[J].Phys Sportsmed,2015,43(1):37-43.
[18] KIM K,VANCE T M,CHEN M H,et al.Dietary total antioxidant capacity is inversely associated with all-cause and cardiovascular disease death of US adults[J].Eur J Nutr,2018,57(7):2469-2476.
[19] 姚丽,张晓冬,范松华,等.血小板高反应性、坚果消费状况与大动脉粥样硬化性脑梗死复发的相关性研究[J].中国卒中杂志,2019,14(10):998-1003.
[20] CHOI Y,CHANG Y,RYU S,et al.Coffee consumption and coronary artery calcium in young and middle-aged asymptomatic adults[J].Heart,2015,101(9):686-691.
[21] DING M,BHUPATHIRAJU S N,SATIJA A,et al.Long-term coffee consumption and risk of cardiovascular disease:a systematic review and a dose-response meta-analysis of prospective cohort studies[J].Circulation,2014,129(6):643-659.
[22] ZHANG Z Z,HU G,CABALLERO B,et al.Habitual coffee consumption and risk of hypertension:a systematic review and meta-analysis of prospective observational studies[J].Am J Clin Nutr,2011,93(6):1212-1219.
[23] URGERT R,KATAN M B.The cholesterol-raising factor from coffee beans[J].Annu Rev Nutr,1997,17:305-324.
[24] COSTANZO S,DI CASTELNUOVO A,DONATI M B,et al.Wine,beer or spirit drinking in relation to fatal and non-fatal cardiovascular events:a meta-analysis[J].Eur J Epidemiol,2011,26(11):833-850.
[25] MATHEWS M J,LIEBENBERG L,MATHEWS E H.The mechanism by which moderate alcohol consumption influences coronary heart disease[J/OL].Nutr J,2015,14[2024-04-27].https://doi.org/10.1186/s12937-015-0011-6.
[26] O'KEEFE E L,DINICOLANTONIO J J,O'KEEFE J H,et al.Alcohol and CV health:Jekyll and Hyde J-curves[J].Prog Cardiovasc Dis,2018,61(1):68-75.
[27] 黄文,何亮,傅玲娟,等.动脉粥样硬化性心血管疾病高危人群血脂控制达标的影响因素研究[J].预防医学,2023,35(10):834-839.
[28] CHATZIKONSTANTINOU A,EBERT A D,SCHOENBERG S O,et al.Atherosclerosis in intracranial,extracranial,and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology[J].Int J Neurosci,2015,125(9):663-670. |
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