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Influencing factors of molecular network transmission clusters of HIV/AIDS in Huzhou |
*JIN Meihua, LI Jing, LIU Xiaoqi, CHEN Lin, YANG Zhongrong
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*Huzhou Center for Disease Control and Prevention, Huzhou, Zhejiang 313000, China |
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Abstract Objective To analyze the influencing factors for the molecular network transmission clusters of HIV/AIDS, and to provide scientific evidence for the precise prevention and control of AIDS. Methods A case-control study was conducted. The HIV/AIDS cases reported from January 2017 to June 2019 in Huzhou with strong clustering of HIV molecular transmission were recruited as the case group, and the residents with same gender, similar age ( ±three years ) and HIV negative in the same community and period were matched ( 1∶4 ) as the control group. Demographic characteristics, AIDS related knowledge and sexual behaviors were collected by a questionnaire survey. The Cox regression model was used to analyze the influencing factors for HIV/AIDS molecular network transmission cluster. Results There was 100 people in the case group and 400 people in the control group, the differences between them in age, sex, marital status, place of residence and educational level were not statistically significant ( P>0.05 ) . The results of multivariate Cox regression analysis showed that awareness of AIDS related knowledge ( HR=0.145, 95%CI: 0.059-0.352 ) was a protective factor for molecular network transmission clusters of HIV/AIDS; men who have sex wth men ( MSM, HR=9.614, 95%CI: 4.645-19.901) , seeking homosexual partners through the internet (HR=16.321, 95%CI: 7.016-32.968) and having syphilis ( HR=3.314, 95%CI: 1.073-10.232 ) were risk factors for molecular network transmission clusters of HIV/AIDS. Conclusions The awareness of AIDS related knowledge, MSM, seeking homosexual partners through the internet and suffering from syphilis are the influencing factors for molecular network transmission clusters of HIV/AIDS.
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Received: 08 May 2020
Revised: 28 June 2020
Published: 30 September 2020
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[1] 甘梦泽,冯毅,邢辉.基于分子网络方法研究HIV感染者传播特征的相关进展[J].中华流行病学杂志,2019,40(11):1487-1491. [2] 黎裕雪云,冯毅,阮玉华,等.HIV分子传播网络研究进展[J].中国艾滋病性病,2016,22(11):940-942. [3] KOSTAKI E G,NIKOLOPOULOS G K,PAVLITINA E,et al.Molecular analysis of human immunodeficiency virus type 1 (HIV-1)-infected individuals in a network-based intervention (transmission reduction intervention project):phylogenetics identify HIV-1-infected individuals with social links[J].J Infect Dis,2018,218(5):707-715. [4] KOSTAKI E G,FRAMPTON D,PARASKEVIS D,et al.Near full-length genomic sequencing and molecular analysis of HIV-infected individuals in a network-based intervention (TRIP) in Athens, Greece:evidence that transmissions occur more frequently from those with high HIV-RNA[J].Curr HIV Res,2018,16(5):345-353. [5] WERTHEIM J O,OSTER A M, SWITZER W M,et al.Natural selection favoring more transmissible HIV detected in United States molecular transmission network[J/OL].Nat Commun,2019,10(1)[2020-06-28]. https://doi.org/10.1038/s41467-019-13723-z. [6] YANG Z,LI J,DONG Z,et al.Correlates of recent HIV infection among men who have sex with men recruited through the internet in Huzhou City, Eastern China[J].J Int Med Res,2018,46(12):5052-5061. [7] 吴尊友. 我国艾滋病经性传播新特征与防治面临的挑战[J].中华流行病学杂志,2018,39(6):707-709. [8] 陈婉君,潘晓红,范钦,等.应用分子传播网络分析浙江省湖州市2017年新报告HIV感染者和艾滋病患者的传播特征[J].中华预防医学杂志,2019,53(12):1278-1283. [9] 金玫华,杨中荣,李婧,等.性病门诊男性就诊者梅毒感染及影响因素分析[J].预防医学,2018,30(8):809-811,815. [10] ZHANG T Q,MIAO Y,LI L G,et al.Awareness of HIV/AIDS and its routes of transmission as well as access to health knowledge among rural residents in Western China: a cross-sectional study[J/OL].BMC Public Health, 2019,19(1)[2020-06-28].https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7992-6. [11] 李娜,施明明,陈俊,等.上城区VCT门诊求询者HIV感染状况分析[J].预防医学,2019,31(6):597-599. [12] 张兴亮,罗艳,丁建明,等.2017年杭州市新确诊男男性行为人群HIV/AIDS病例特征分析[J].预防医学,2020,32(4): 373-377. [13] 杨爱学,李淼.奎屯市244例MSM人群艾滋病知识行为及感染状况分析[J].实用预防医学,2018,25(5):576-579. [14] TAKADA S,NYAKATO V,NISHI A,et al.The social network context of HIV stigma: population-based,sociocentric network study in rural Uganda[J].Soc Sci Med,2019,233:229-236. [15] KATZ D A,DOMBROWSKI J C,BARRY M,et al.STD partner services to monitor and promote HIV pre-exposure prophylaxis use among men who have sex with men[J].J Acquir Immune Defic Syndr,2019,80(5):533-541. [16] TRAYNOR S M,ROSEN-METSCH L,FEASTER D J.Missed opportunities for HIV testing among STD clinic patients[J].J Community Health,2018,43(6):1128-1136. |
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