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| Effect of exercise prescription intervention among patients with type 2 diabetes mellitus |
| WEN Jinbo1, ZHANG Ting1, ZHAO Qian1, LIU Jing1, SUN Zhongming1, HOU Jianbin2, LU Zhengquan3, XU Yuting1, MA Xinxiong4, PAN Enchun1
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1. Huai'an Center for Disease Control and Prevention, Huai'an, Jiangsu 223001, China;
2. Shizhong Community Health Service Center, Qingjiangpu District, Huai'an, Jiangsu 223001, China;
3. Bochishan Community Health Service Center, Qingjiangpu District, Huai'an, Jiangsu 223001, China;
4. School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China |
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Abstract Objective To evaluate the effect of exercise prescription intervention among patients with type 2 diabetes mellitus (T2DM), so as to provide the evidence for guiding appropriate physical activity and glycemic control in this population. Methods In July 2023, T2DM patients managed by two community health service centers in Qingjiangpu District, Huai'an City, Jiangsu Province, were selected as the study participants and randomly assigned divided into a control group and an intervention group. The control group received routine chronic disease management under the basic public health services, while the intervention group, in addition to receiving the same routine chronic disease management, was provided with exercise prescription to guide their physical activity at baseline (T0), after 3 months of intervention (T1), and after 6 months of intervention (T2). Data on weight-related indicators, glycated hemoglobin (HbA1c), and blood lipid were collected through physical examinations and laboratory tests at T0 and after 12 months of intervention (T3). The differences in indicators between the two groups before and after the intervention were analyzed using generalized estimating equations. Results The intervention group consisted of 197 patients, including 99 males, accounting for 50.25%. The median disease duration was 7.10 (interquartile range, 7.80) years, and 113 patients had suboptimal HbA1c levels, accounting for 57.36%. The control group included 196 patients, including 99 females, accounting for 50.51%. The median disease duration was 6.10 (interquartile range, 7.00) years, and 100 patients had suboptimal HbA1c levels, accounting for 51.02%. Before the intervention, no statistically significant differences were observed between the two groups in gender, educational level, disease duration, pharmacological treatment, smoking, alcohol consumption, and HbA1c levels (all P>0.05). In the intervention group, the proportion of participants engaging in aerobic exercise and strength training increased from 78.17% and 8.12% at T0 to 85.79% and 16.24% at T3, respectively (both P<0.05). The results of the generalized estimating equations revealed significant interactions between group and time for waist-to-hip ratio, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) following the intervention (all P<0.05). A statistically significant difference in waist-to-hip ratio was found between the two groups (P<0.05), with a greater reduction observed in the intervention group compared to the control group. Significant differences in TC and LDL-C levels were noted across different intervention time points (both P<0.05). Specifically, the intervention group demonstrated reductions of 0.35 mmol/L in TC and 0.42 mmol/L in LDL-C from baseline to follow-up (both P<0.05). Conclusion The 12-month exercise prescription intervention can effectively enhance exercise participation and reduce waist-to-hip ratio, TC, and LDL-C levels among patients with T2DM.
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Received: 16 July 2025
Revised: 23 November 2025
Published: 25 December 2025
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[1] NCD Risk Factor Collaboration.Worldwide trends in diabetes prevalence and treatment from 1990 to 2022:a pooled analysis of 1 108 population-representative studies with 141 million participants[J].Lancet,2024,404(10467):2077-2093.
[2] 高明妃,胡如英,胡崇高.中国糖尿病死亡流行特征研究进展[J].预防医学,2022,34(7):692-695.
GAO M F,HU R Y,HU C G.Research progress on epidemiological characteristics of death of diabetes in China[J].China Prev Med J,2022,34(7):692-695.(in Chinese)
[3] 梁栋,杨成琳,林晓茹,等.1990—2019年中国成年人归因于糖尿病的心血管疾病负担研究[J].中国全科医学,2024,27(11):1380-1386,1394.
LIANG D,YANG C L,LIN X R,et al.Burden of cardiovascular diseases attributable to diabetes among Chinese adults from 1990 to 2019[J].Chin Gen Pract,2024,27(11):1380-1386,1394.(in Chinese)
[4] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315?409.
Chinese Diabetes Society.Guideline for the prevention and treatment of type 2 diabetes mellitus in China(2020 edition)[J].China J Diabetes Mellit,2021,13(4):315-409.(in Chinese)
[5] SCHUBERT-OLESEN O,KRÖGER J,SIEGMUND T,et al.Continuous glucose monitoring and physical activity[J/OL].Int J Environ Res Public Health,2022,19(19)[2025-11-23] .https://doi.org/10.3390/ijerph191912296.
[6] 王凯,徐百超,王朝昕,等.组合运动干预对肥胖女青少年身体成分、心血管风险因素及心肺适能影响的研究[J].中国全科医学,2024,27(9):1109-1117.
WANG K,XU B C,WANG Z X,et al.Effects of combined motion intervention on body composition,cardiovascular risk factors and cardiopulmonary fitness of obese female adolescents[J].Chin Gen Pract,2024,27(9):1109-1117.(in Chinese)
[7] 中华人民共和国国家老年医学中心,中华医学会糖尿病学分会,中国体育科学学会,等.中国2型糖尿病运动治疗指南(2024版)[J].中华糖尿病杂志,2024,16(6):616-647.
National Clinical Research Center for Geriatrics,Chinese Diabetes Society,China Sport Science Society,et al.Guidelines for exercise therapy of type 2 diabetes in China (2024 edition)[J].Chin J Diabetes Mellit,2024,16(6):616-647.(in Chinese)
[8] 国家体育总局运动医学研究所,中国女医师协会医学体育专委会,中国体育科学学会运动医学分会.临床运动处方实践专家共识(2025)[J].中国运动医学杂志,2025,44(5):341-357.
Institute of Sports Medicine,General Administration of Sport of China,Medical Sports Committee,Chinese Women Doctor's Association,Sports Medicine Branch,Chinese Society of Sports Science.Expert consensus on clinical exercise prescription practice (2025)[J].Chin J Phys Med,2025,44(5):341-357.(in Chinese)
[9] AL-MHANNA S B,ALGHANNAM A F,ALKHAMEES N H,et al.Impact of concurrent aerobic and resistance training on body composition,lipid metabolism and physical function in patients with type 2 diabetes and overweight/obesity:a systematic review and meta-analysis[J/OL].Peer J,2025,13[2025-11-23] .https://doi.org/10.7717/peerj.19537.
[10] ZHANG J H,TAM W W S,HOUNSRI K,et al.Effectiveness of combined aerobic and resistance exercise on cognition,metabolic health,physical function,and health-related quality of life in middle-aged and older adults with type 2 diabetes mellitus:a systematic review and meta-analysis[J].Arch Phys Med Rehabil,2024,105(8):1585-1599.
[11] CARDOSO A M,DE LIMA A C,MANICA A,et al.The anti-inflammatory effect of physical exercise on type 2 diabetes:the role of purinergic signaling[J].Purinergic Signal,2025,21(5):1201-1213.
[12] BANCKS M P,CARNETHON M,CHEN H Y,et al.Diabetes subgroups and risk for complications:the Multi-Ethnic Study of Atherosclerosis (MESA)[J/OL].J Diabetes Complications,2021,35(6)[2025-11-23] .https://doi.org/10.1016/j.jdiacomp.2021.107915.
[13] ZHU X Y,ZHANG F,CHEN J,et al.The effects of supervised exercise training on weight control and other metabolic outcomes in patients with type 2 diabetes:a meta-analysis[J].Int J Sport Nutr Exerc Metab,2022,32(3):186-194.
[14] LIU H R,WANG W L,SUN J.Bayesian network meta-analysis of the impact of exercise therapy on blood glucose in type 2 diabetes patients[J/OL].Front Endocrinol,2025,16[2025-11-23] .https://doi.org/10.3389/fendo.2025.1658739.
[15] 谭颜蓉,张新涛,任玉香,等.体医融合背景下运动处方护理干预模式对2型糖尿病血糖指标的影响[J].全科护理,2024,22(17):3265-3269.
TAN Y R,ZHANG X T,REN Y X,et al.Effect of nursing intervention mode of exercise prescription on blood sugar index of type 2 diabetes mellitus under the background of integration of sports and medicine[J].Chin Gen Pract Nurs,2024,22(17):3265-3269.(in Chinese) |
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