|
|
Evaluation on protective effect of influenza vaccine among people aged 70 years and older in Jiaxing City |
HOU Zhigang, LIU Yang, GE Rui, QI Yunpeng, FU Xiaofei
|
Department of Infectious Disease Control and Prevention, Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang 314050, China |
|
|
Abstract Objective To evaluate the protective effect of influenza vaccine among people aged 70 years and older in Jiaxing City, Zhejiang Province, so as to provide a basis for formulating immunization strategies. Methods The influenza-like illness (ILI) cases aged 70 years and older treated in influenza surveillance sentinel hospital in Jiaxing City from November 2022 to May 2023 were selected. The medical information and influenza vaccination information were collected by a questionnaire survey, and influenza virus was detected using the quantitative fluorescent real-time PCR assay. The test-negative design case-control study was used to analyze the influencing factors of influenza virus positive and evaluate vaccine effect (VE). Results Totally 1 084 ILI cases were enrolled, including 535 males (49.35%) and 549 females (50.64%). There were 732 cases (67.53%) aged 70 to 79 years, and 352 cases (32.47%) aged 80 years and older. There were 689 cases with underlying diseases, accounting for 63.56%. A total of 224 influenza virus positive samples were detected, with a positive rate of 20.66%. Multivariable logistic regression analysis showed that a lower possibility of influenza virus positive was seen in ILI cases aged 80 years and older, with underlying diseases and with influenza vaccination in the current season (all P<0.05). A total of 345 cases were vaccinated against influenza in the current season, with a vaccination rate of 31.83%. The VE of influenza vaccine was 37.40% (95%CI: 12.40%-55.40%), of which the VE to A (H1N1) was 36.00% (95%CI: 7.50%-55.70%) and to A (H3N2) was 40.90% (95%CI: -26.00%-72.30%). The VE for ILI cases aged 70 to 79 years was 41.00% (95%CI: 13.90%-59.60%), and for ILI cases aged 80 years and older was 20.60% (95%CI: -64.60%-61.70%). Conclusions Influenza vaccine has a certain protective effect on cases aged 70 years and older. Free influenza vaccination for the elderly should be continuously promoted and the vaccination coverage should be increased.
|
Received: 14 August 2023
Revised: 30 October 2023
Published: 15 December 2023
|
|
|
|
|
[1] KRAMMER F,SMITH G,FOUCHIER R,et al.Influenza[J/OL].Nat Rev Dis Primers,2018,4(1)[2023-10-30].https://doi.org/10.1038/s41572-018-0002-y. [2] 中华预防医学会流感预防控制工作委员会.促进老年人季节性流感疫苗接种专家共识[J].中华医学杂志,2021,101(8):530-538. [3] 席俊彦,张艳霞,林晓,等.1990—2050年中国人口老龄化对慢性非传染性疾病负担的影响[J].中华预防医学杂志,2023,57(5)667-673. [4] 孙烨祥,张弦,沈鹏,等.≥70岁老年人接种流感疫苗的保护效果真实世界回顾性队列研究[J].中国疫苗和免疫,2023,29(3):253-260. [5] 杨桂月,潘兴强,赵芬,等.中国老年人群流行性感冒疫苗保护效果的Meta分析[J].预防医学,2017,29(6):555-561. [6] 徐放,陈巧明,周蕴丽,等.椒江区老年人接种流感疫苗的保护效果[J].预防医学,2020,32(10):1051-1054. [7] 张代涛,初艳慧,李洪军,等.季节性流感疫苗对严重急性呼吸道感染的保护效果分析[J].国际病毒学杂志,2019,26(2):77-81. [8] 刘艳,金玫华,沈建勇,等.新型冠状病毒肺炎疫情防控措施对湖州市流行性感冒流行特征的影响[J].预防医学,2021,33(4):332-336. [9] 张力,金鹏飞,李靖欣,等.检测阴性设计在疫苗效果评价中的应用[J].中华流行病学杂志,2020,41(2):280-283. [10] 孙品晶,董莹,李清,等.海宁市老年人流感疫苗接种效果评价[J].预防医学,2020,32(9):929-932. [11] 杨孝坤. 我国流感疫苗保护效果评价[D].北京:中国疾病预防控制中心,2021. [12] 严涵,杨娟,陈志元,等.中国60岁及以上老年人接种四价流感疫苗的成本效果分析[J].中华医学杂志,2021,101(30):2405-2412. [13] 伊丽萍,张婉青,陈立凌,等.基于检测阴性设计2011—2021年儿童流感疫苗保护效果评价[J].中国公共卫生,2022,38(6):689-693. [14] WEI Z,SUN X,YANG Y,et al.Seasonal influenza vaccine hesitancy profiles and determinants among Chinese children's guardians and the elderly[J].Expert Rev Vaccines,2021,20(5):601-610. [15] 丁睿尧,阿克忠,马艳梅,等.2019—2021年青海省≥60岁老年人流感疫苗接种率和影响因素调查[J].中国疫苗和免疫,2023,29(4):432-435. [16] 付小强,颜娜,徐小玲,等.鄂州市居民流感疫苗接种意愿及影响因素分析[J].预防医学,2022,34(12):1273-1278,1282. [17] 陶长余,徐红,廉丽华,等.2型糖尿病患者接种流感疫苗的影响因素研究[J].预防医学,2021,33(11):1139-1141,1145. [18] 耿少良,崔亚辉,贺超才,等.许昌市城区60岁以上老年人流感疫苗知识及接种意愿调查[J].现代预防医学,2017,44(2):288-292. [19] 孙承媛,王玫,蒋梦巧,等.基于倾向得分匹配的老年人接种流感疫苗对流感就诊的保护效果研究[J].现代预防医学,2021,48(1):1-4,18. [20] 舒跃龙,文思敏.流感疫苗保护效果的影响因素研究进展[J].山东大学学报(医学版),2021,59(5):1-7. [21] 李萍萍,罗丽,吴一峰,等.老年人接种三价流感病毒裂解疫苗的免疫原性评价[J].预防医学,2022,34(3):277-281. [22] 朱光辉,梁兴宇,郭妙莲,等.宁波市老年人接种流感疫苗的保护效果回顾性分析[J].中国公共卫生管理,2021,37(6):787-789. |
|
|
|