|
|
|
| Detection of glucolipid metabolism and sex hormones among female children with precocious puberty |
| CHEN Dongchan, JIN Wei
|
| Department of Pediatrics, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang 313000, China |
|
|
|
|
Abstract Objective To investigate glucolipid metabolism and sex hormone levels among female children with precocious puberty, so as to provide insights into the illustration of pathogenesis of precocious puberty. Methods A total of 110 female children with precocious puberty treated in Huzhou Maternity & Child Health Care Hospital during the period from May 2019 through May 2021 were enrolled and assigned into the idiopathic central precocious puberty (ICPP) group and the premature thelarche alone (PT) group according to the results of gonadotropin-releasing hormone stimulation tests. The follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), estradiol (E2), testosterone (T), prolactin (PRL), fasting insulin (FINS), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB) andlipoprotein-a [Lp (a)] levels were detected and compared in children between the ICPP and PT groups. Results There were 70 cases in the ICCP group, with a mean age of (7.62±1.13) years and a mean body mass index (BMI) of (16.30±2.21) kg/m2 and 40 cases in the PT group, with a mean age of (7.42±1.04) years and a mean BMI of (16.70±2.10) kg/m2 (both P>0.05). The FSH [(3.58±0.80) vs. (2.22±0.75) IU/L], LH [(1.40±0.28) vs. (0.25±0.12) IU/L], P [(0.29±0.12) vs. (0.18±0.08) ng/mL], E2 [(23.28±4.23) vs. (15.54±2.75) pg/mL] and PRL [(8.56±1.93) vs. (6.54±1.50) ng/mL], FINS [(13.24±2.54) vs. (11.10±2.49) U/L], TG [(1.36±0.17) vs. (1.21±0.27) mmol/L], LDL-C [(3.10±0.44) vs. (2.81±0.60) mmol/L], ApoB [(0.78±0.19) vs. (0.71±0.14) g/L] and Lp (a) levels [(252.45±52.10) vs. (202.60±41.28) mg/L] were significantly higher in the ICPP group than in the PT group (all P<0.05). Conclusion The levels of sex hormones and glucolipid metabolism parameters are significantly higher among female children with ICPP than among those with PT.
|
|
Received: 24 May 2022
Revised: 06 July 2022
Published: 08 September 2022
|
|
|
|
|
|
[1] GANGAT M,RADOVICK S.Precocious puberty[J].Minerva Pediatr,2020,72(6):491-500.
[2] GOHIL A,EUGSTER E A.Delayed and precocious puberty:genetic underpinnings and treatments[J].Endocrinol Metab Clin North Am,2020,49(4):741-757.
[3] HERAS V,CASTELLANO J M,FERNANDOIS D,et al.Central ceramide signaling mediates obesity-induced precocious puberty[J].Cell Metab,2020,32(6):951-966.
[4] 邢超,徐来潮,方益荣,等.绍兴市2所初中女生月经初潮年龄及影响因素[J].预防医学,2017,29(2):182-184.
XING C,XU L C,FANG Y R,et al.Menarcheal age of students in two secondary schools in Shaoxing City and its influencing factors[J].Prev Med,2017,29(2):182-184.
[5] 唐家彦,黄娟,黄连红,等.中枢性性早熟女童血清miR-125b与维生素D联合检测的临床意义研究[J].中国全科医学,2019,22(9):1047-1051.
TANG J Y,HUANG J,HUANG L H,et al.Clinical significance of combined detection of serum miR-125b and vitamin D in female children with central precocious puberty[J].Chin Gen Pract,2019,22(9):1047-1051.
[6] 孟凡顺,谌丁艳,吴宇,等.深圳市学龄女童膳食模式和性早熟的相关性研究[J].中华流行病学杂志,2020,41(5):738-742.
MENG F S,CHEN D Y,WU Y,et al.Study of relationship between dietary patterns and precocious puberty of school-age girls in Shenzhen[J].Chin J Epidemiol,2020,41(5):738-742.
[7] ALMUTLAQ N,O'NEIL J,FUQUA J S.Central precocious puberty in spina bifida children:guidelines for the care of people with spina bifida[J].J Pediatr Rehabil Med,2020,13(4):557-563.
[8] 中华医学会儿科学分会内分泌遗传代谢学组,《中华儿科杂志》编辑委员会.中枢性性早熟诊断与治疗共识(2015)[J].中华儿科杂志,2015,53(6):412-418.
Chinese Society of Pediatrics,Editorial Board of Chinese Journal of Pediatrics.Diagnosis and treatment consensus on central precocious puberty(2015)[J].Chin J Pediatr,2015,53(6):412-418.
[9] 马晓宇,倪继红,杨露露,等.GnRHa治疗对特发性中枢性性早熟和快速进展型早发育儿童的远期影响[J].中华内分泌代谢杂志,2020,36(1):58-62.
MA X Y,NI J H,YANG L L,et al.Long-term effects of GnRHa on central precocious puberty or early and fast puberty children[J].Chin J Endocrinol Metab,2020,36(1):58-62.
[10] 白敏,韩宜姚,李珍,等.醋酸曲普瑞林治疗特发性中枢性性早熟女童疗效及对下丘脑-垂体-性腺轴激素水平的影响[J].重庆医学,2020,49(7):1128-1131.
BAI M,HAN Y Y,LI Z,et al.Therapeutic effect of triptorelin acetate on idiopathic central precocious puberty in girls and its effect on hormone levels of hypothalamus-pituitary-gonadal axis[J].Chongqing Med,2020,49(7):1128-1131.
[11] LIU S,ZHU X,WANG Y,et al.The association between vitamin D levels and precocious puberty:a meta-analysis[J].J Pediatr Endocrinol Metab,2020,33(3):427-429.
[12] YU X,YANG X,ZHAO Y,et al.A comparison of the growth status,level of blood glucose,and lipid metabolism in small for gestational age and appropriate for gestational age girls with central precocious puberty:a retrospective study[J].Transl Pediatr,2021,10(4):783-789.
[13] KLEIN K O,FREIRE A,GRYNGARTEN M G,et al.Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty[J].J Clin Endocrinol Metab,2020,105(10):3660-3671.
[14] DAYAL D,YADAV J,SEETHARAMAN K,et al.Etiological spectrum of precocious puberty:data from northwest India[J].Indian Pediatr,2020,57(1):63-64.
[15] RAMOS C O,CANTON A P M,SERAPHIM C E,et al.Anthropometric,metabolic,and reproductive outcomes of patients with central precocious puberty treated with leuprorelin acetate 3-month depot(11.25 mg)[J].J Pediatr Endocrinol Metab,2021,34(11):1371-1377.
[16] ARCARI A J,FREIRE A V,ESCOBAR M E,et al.One-year treatment with gonadotropin-releasing hormone analogues does not affect body mass index,insulin sensitivity or lipid profile in girls with central precocious puberty[J].J Pediatr Endocrinol Metab,2019,32(2):181-186.
[17] FURTADO C L M,IANNETTA R,FERRIANI R A,et al.Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog-leuprolide acetate[J].Gynecol Endocrinol,2020,36(12):1119-1123. |
|
|
|
