|
|
|
| Seroepidemiology of varicella-zoster virus antibody levels amongchildren aged 1 to 12 years in Lu'an City |
| CHEN Beilei1, WANG Yao2, CHEN Zhichao1, PAN Fan2, XIE Shaoyu2, QIN Wei2,3
|
1. Lu'an Center for Disease Control and Prevention, Lu'an, Anhui 237000, China;
2. Lu'an Center for Disease Control and Prevention, Lu'an, Anhui 237000, China;
3. Anhui Medical University, Hefei, Anhui 230032, China |
|
|
|
|
Abstract Objective To detect varicella-zoster virus ( VZV ) antibody levels among children aged 1 to 12 years in Lu'an City, Anhui Province, so as to provide insights into perfection of the varicella immunization strategy. Methods Children aged 1 to 12 years were recruited from Lu'an City using the stratified random sampling method from July 2018 to February 2019, and subjects' demographics were collected using questionnaires. The inoculation of varicella vaccines was retrieved through the Anhui Immunization Information Management System or review of preventive immunization certificates, and the serum VZV IgG antibody was detected using enzyme-linked immunosorbent assay ( ELISA ). The seroprevalence and geometric mean concentration of the VZV-IgG antibody were estimated, and the changes of serum the VZV-IgG antibody levels were analyzed at different time intervals following varicella vaccination. Results Totally 734 children were surveyed, with a mean age of ( 6.94±2.95 ) years, and the subjects included 412 boys ( 56.13% ) and 322 girls ( 43.87% ). There were 514 children ( 70.03% ) with a history of varicella vaccination, including 501 children ( 68.26% ) with one dose of varicella vaccine and 13 children ( 1.77% ) with two doses. There were 297 children ( 40.46% ) positive for VZV-IgG antibody, with seroprevalence of 40.46%, and the GMC of VZV-IgG antibody was 74.97 ( 95%CI: 65.55-85.75 ) mIU/mL. The seroprevalence of the VZV-IgG antibody were 34.55%, 42.91%, and 46.15% among the unvaccinated children and children receiving one dose and two doses of varicella vaccine, with the GMCs of 53.04, 86.31 and 114.46 mIU/mL, respectively. The mean time interval between inoculation of the last dose of varicella vaccine and blood sample collection was ( 5.21±2.79 ) years, and the lowest seroprevalene (31.48%) and GMC of the VZV-IgG antibody (49.96 mIU/mL) were found 4 years after inoculation of varicella vaccine. Conclusions The serum VZV-IgG antibody level is low among children aged 1 to 12 years in Lu'an City, and the seroprevalence of the VZV-IgG antibody is affected by age and doses of varicella vaccine. A 2-dose schedule of varicella vaccine is recommended for children.
|
|
Received: 27 December 2021
Revised: 09 March 2022
Published: 12 May 2022
|
|
|
|
|
|
[1] 刘安平,孙婷婷.中国儿童水痘疫苗接种率Meta分析[J].中国疫苗和免疫,2017,23(6):698-704.
LIU A P,SUN T T.Meta-analysis of varicella vaccine coverage among Chinese children[J].Chin J Vaccines Immunization,2017,23(6):698-704.
[2] 许小康,孟祥梅,王瑶,等.六安市某小学水痘暴发疫情突破病例分析[J].预防医学,2020,32(3):289-291.
XU X K,MENG X M,WANG Y,et al.Analysis of breakout cases of a varicella outbreak in a primary school in Lu'an[J].Prev Med,2020,32(3):289-291.
[3] QIN W,MENG X M,ZHANG L,et al.The impact of long-term moderate level of vaccination coverage for epidemiology of varicella in Lu'an,China:should we change immunisation strategy now?[J/OL].Epidemiol Infect,2020,148(2001-03-01)[2022-03-09].https://doi.org/10.1017/S0950268820000667.
[4] QIN W,XU X K,WANG Y,et al.Clinical characteristics and risk factors associated with breakthrough varicella during varicella outbreaks[J].Hum Vaccin Immunother,2020,16(8):1851-1856.
[5] 朱珠英,周珊慧.龙湾区健康人群水痘-带状疱疹病毒抗体水平调查[J].预防医学,2020,32(11):1144-1146.
ZHU Z Y,ZHOU S H.Antibody level of varicella-zoster virus in healthy population in Longwan District[J].Prev Med,2020,32(11):1144-1146.
[6] 李玺琨,高晓丽,李岩,等.2016年哈尔滨市1~19岁健康人群水痘血清流行病学调查[J].中国当代儿科杂志,2019,21(3):203-207.
LI X K,GAO X L,LI Y,et al.Seroepidemiology of varicella among the healthy population aged 1-19 years in Harbin,China[J].Chin J Contemp Pediatr,2019,21(3):203-207.
[7] 王庆,孙穆,崔长弘,等.北京市西城区健康人群水痘-带状疱疹病毒抗体水平调查研究[J].中国预防医学杂志,2017,18(3):223-225.
WANG Q,SUN M,CUI C H,et al.Investigation on antibody level of varicella-zoster virus in healthy populations in Xicheng District,Beijing[J].Chin Prev Med,2017,18(3):223-225.
[8] 赵云,李敏,姚增芸,等.济南市历城区1~12岁儿童水痘-带状疱疹病毒抗体水平调查[J].中国疫苗和免疫,2017,23(3):298-301,297.
ZHAO Y,LI M,YAO Z Y,et al.Survey of antibody levels against varicella-zoster virus in children aged 1-12 years in Licheng district,Jinan city[J].Chin J Vaccines Immunization,2017,23(3):298-301,297.
[9] LUAN L,SHEN X C,QIU J,et al.Seroprevalence and molecular characteristics of varicella-zoster virus infection in Chinese children[J/OL].BMC Infect Dis,2019,19(1)(2019-07-19)[2022-03-09].https://doi.org/10.1186/s12879-019-4233-7.
[10] 徐志荣,郭鸿平,周婷,等.昆明市官渡区2019年1~14岁健康儿童水痘-带状疱疹病毒抗体水平[J].中国疫苗和免疫,2020,26(3):290-292.
XU Z R,GUO H P,ZHOU T,et al.Antibody levels against varicella-zoster virus among 1-14-year-old healthy children in Guandu district of Kunming city,2019[J].Chin J Vaccines Immunization,2020,26(3):290-292.
[11] 王涛,朱宗龙,苑新海,等.2017年北京市昌平区健康人群水痘——带状疱疹病毒抗体水平监测[J].公共卫生与预防医学,2018,29(3):104-106.
WANG T,ZHU Z L,YUAN X H,et al.Antibody levels against varicella-zoster virus in a healthy population in Changping District,Beijing(2017)[J].J Public Health Prev Med,2018,29(3):104-106.
[12] 周珺,李健雄,施勇,等.2017年江西省部分地区健康人群血清水痘-带状疱疹病毒IgG抗体水平调查[J].实验与检验医学,2018,36(6):1000-1003.
ZHOU J,LI J X,SHI Y,et al.Investigation on serum IgG antibody level of varicella-zoster virus among healthy people in some areas of Jiangxi Province in 2017[J].Exp Lab Med,2018,36(6):1000-1003.
[13] 赵春艳,石晶,张玲,等.北京市通州区健康儿童水痘-带状疱疹病毒抗体水平特征分析[J].中国生物制品学杂志,2019,32(12):1377-1380.
ZHAO C Y,SHI J,ZHANG L,et al.Characteristics of antibody levels against varicella-zoster virus in healthy children in Tongzhou District,Beijing[J].Chin J Biol,2019,32(12):1377-1380.
[14] 赫欣,刘畅,崔明辰,等.河南省健康人群水痘-带状疱疹病毒抗体水平调查[J].中国公共卫生,2015,31(10):1301-1303.
HE X,LIU C,CUI M C,et al.Serum level of varicella-zoster virus antibody among healthy residents in Henan province[J].Chin J Public Health,2015,31(10):1301-1303.
[15] World Health Organization.Varicella and herpes zoster vaccines:WHO position paper,June 2014[J].Wkly Epidemiol Rec,2014,89(25):265-287. |
|
|
|
