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Factors affecting postmenopausal osteoporosis in Dali Bai Autonomous Prefecture |
GAO Yujie, CHEN Xiaoyun, SHA Yanmei, WANG Xiaofen, HAN Guangfei, LI Weijuan, YANG Lei, WEN Haimei, HU Xueqin
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Department of Geriatrics, Dali Prefecture People's Hospital, Dali, Yunnan 671000, China |
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Abstract Objective To investigate the prevalence of postmenopausal osteoporosis (PMOP) and analyze its influencing factors among women at ages of 50 to 59 years in Dali Bai Autonomous Prefecture, Yunnan Province, so as to provide insights into the prevention of PMOP among menopausal women. Methods Bai Ethnic menopausal women at ages of 50 to 59 years who received healthy examination at the Center of Healthy Examination, Dali Prefecture People's Hospital from June 2017 to May 2021 were selected as the study subjects, and subjects' demographic characteristics, living habits, history of diseases, family history of osteoporosis and history of parturition were collected using self-designed questionnaires. The height, body weight and bone density were measured, and fasting blood glucose, vitamin D3, blood lipids and liver functions were detected. The factors affecting the development of PMOP were identified using a multivariable logistic regression model. Results Totally 2 000 questionnaires were allocated, and 1 584 valid questionnaires were recovered, with an effective recovery rate of 79.20%. The respondents had a mean age of ( 56.22±2.61 ) years, and mean body mass index ( BMI ) of ( 24.62±2.35 ) kg/m2. There were 497 respondents ( 31.38% ) with a family history of osteoporosis, and the prevalence of PMOP was 20.64%. Multivariable logistic regression analysis identified age ( OR=1.135, 95%CI: 1.074-1.196 ), age of menarche ( OR=1.138, 95%CI: 1.059-1.217 ), duration of menopause (OR=1.425, 95%CI: 1.228-1.622), number of parturition ( >2, OR=5.036, 95%CI: 2.972-7.101 ), smoking ( OR=2.594, 95%CI: 1.767- 3.421 ), alcohol consumption ( OR=2.051, 95%CI: 1.503-2.598 ), family history of osteoporosis ( OR=2.540, 95%CI: 1.769-3.311 ), hypertension ( OR=1.492, 95%CI: 1.406-1.578 ), diabetes ( OR=1.774, 95%CI: 1.581-1.967 ), total cholesterol ( OR=1.483, 95%CI: 1.251-1.716 ), triacylglycerol ( OR=1.801, 95%CI: 1.576-2.026 ), low-density lipoprotein cholesterol ( OR=1.614, 95%CI: 1.498-1.731 ), fasting blood glucose ( OR=1.192, 95%CI: 1.077-1.307 ), BMI ( OR=0.934, 95%CI: 0.862-0.993 ), outdoor activity ( ≥1 time/week, OR: 0.413-0.549, 95%CI: 0.329-0.637 ), age of menopause ( OR=0.909, 95%CI: 0.841-0.977 ), daily intake of calcium ( ≥600 mg, OR: 0.493-0.644, 95%CI: 0.389-0.786 ), vitamin D3 level ( ≥20 ng/mL, OR: 0.604-0.719, 95%CI: 0.523-0.853 ) and high-density lipoprotein cholesterol ( OR=0.658, 95%CI: 0.550-0.767 ) as factors affecting the development of PMOP. Conclusions The prevalence of PMOP in Dali Bai Autonomous Prefecture is similar to the nationwide level in China, and old age, smoking, alcohol consumption, a family history of osteoporosis and high blood lipid levels may increase the risk of PMOP.
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Received: 18 June 2021
Revised: 16 December 2021
Published: 13 April 2022
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[1] KATAOKA Y,LUO Y,CHAIMANI A,et al.Cumulative network meta-analyses,practice guidelines,and actual prescriptions for postmenopausal osteoporosis:a meta-epidemiological study[J/OL].Arch Osteoporos,2020,15(1)(2020-02-23)[2021-12-16].https://link.springer.com/article/10.1007%2Fs11657-020-0697-8.DOI:10.1007/s11657-020-0697-8. [2] 中华医学会骨质疏松和骨矿盐疾病分会.中国骨质疏松症流行病学调查及“健康骨骼”专项行动结果发布[J].中华骨质疏松和骨矿盐疾病杂志,2019,12(4):317-318. Chinese Society of Osteoporosis and Bone Mineral Research.The epidemiological survey of osteoporosis in China and the results of the "Healthy Bones" special action[J].Chin J Osteoporos Bone Miner Res,2019,12(4):317-318. [3] 张惠勤,黄伦浪,孙曾梅,等.藏汉两族骨质疏松相关影响因素调查分析[J].西藏医药,2020,41(3):85-86. ZHANG H Q,HUANG L L,SUN Z M,et al.Analysis of influencing factors for osteoporosis in the Tibetan and Han ethnic groups[J].Tibetan J Med,2020,41(3):85-86. [4] 中国疾病预防控制中心营养与食品安全所.中国食物成分表[M].北京:北京大学医学出版社,2009. [5] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中国全科医学,2017,20(32):3963-3982. Chinese Society of Osteoporosis and Bone Mineral Research. Guidelines for the diagnosis and treatment of primary osteoporosis(2017)[J].Chin Gen Pract,2017,20(32):3963-3982. [6] RIGHINI M,WAN ES J,DEN EXTER P L,et al.Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism:the ADJUST-PE study[J].JAMA,2014,59(5):1117-1124. [7] 柴波,冯皓宇,常强,等.中国各地区绝经后骨质疏松症患病率及骨密度测量检出率分析[J].实用骨科杂志,2020,26(9):792-796. CHAI B,FENG H Y,CHANG Q,et al.Analysis of the prevalence of postmenopausal osteoporosis and the detection rate of bone mineral density in various regions of China[J].J Pract Orthop,2020,26(9):792-796. [8] ILESANMI-OYELERE B L,KRUGER M C.Nutrient and dietary patterns in relation to the pathogenesis of postmenopausal osteoporosis-a literature review[J/OL].Life(Basel),2020,10(10)(2020-09-25)[2021-12-16].https://doi.org/10.3390/life10100220. [9] 毛幸,楼超,周晓明.围绝经期骨质疏松与血清维生素D、雌激素水平的相关性分析[J].中国妇幼保健,2019,34(17):4002-4005. MAO X,LOU C,ZHOU X M.Analysis on the correlation between perimenopausal osteoporosis and serum levels of vitamin D and estrogen[J].Matern Child Health Care China,2019,34(17):4002-4005. [10] ZHANG X,DAI Z L,LAU E H Y,et al.Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China:logistic regression and random forest analysis[J/OL].Ann Transl Med,2020,8(5)(2019-12-27)[2021-12-16].https://atm.amegroups.com/article/view/36401/html.DOI:10.21037/atm.2020.01.08. [11] RAMÍREZ J,NIETO-GONZÁLEZ J C,RODRÍGUEZ R C,et al.Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis:a systematic review and meta-analysis[J].Semin Arthritis Rheum,2018,48(1):44-52. [12] MANGELA-GOMES A,GARCIA-ROSA M L,MASSAE-YOKOO E,et al.Prevalence of osteopenia,osteoporosis and their risk factors in the Niterói Family Doctor Program[J].Salud Publica Mex,2019,61(2):100-101. [13] KAYA A E,DO AN O,BAŞBU A,et al.An evaluation of the association of reproductive history and multiple births during adolescence with postmenopausal osteoporosis[J].Geburtshilfe Frauenheilkd,2019,79(3):300-307. [14] CHAI H,GE J R,LI L,et al.Hypertension is associated with osteoporosis:a case-control study in Chinese postmenopausal women[J/OL].BMC Musculoskelet Disord,2021,22(1)(2021-03-07)[2021-12-16].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938480.DOI:10.1186/s12891-021-04124-9. [15] LI C L,WANG S F,DU M R,et al.Clinical characteristics and controllable risk factors of osteoporosis in elderly men with diabetes mellitus[J].Orthop Surg,2021,13(3):1001-1005. [16] 章允志,刘海燕,李春峰.绝经后骨质疏松症患者骨密度检测及相关因素分析[J].中国妇幼保健,2020,35(3):498-500. ZHANG Y Z,LIU H Y,LI C F.Analysis of bone mineral density and related factors in postmenopausal osteoporosis patients[J].Matern Child Health Care China,2020,35(3):498-500. [17] 蔡程芳,淦细红,陈和珍,等.温州地区绝经后老年女性骨质疏松的患病率及其危险因素分析[J].全科医学临床与教育,2018,16(4):388-413. CAI C F,GAN X H,CHEN H Z,et al.The prevalence and risk factors analysis of osteoporosis among Wenzhou postmenopausal women[J].Clin Educ Gen Pract,2018,16(4):388-413. |
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