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| Preventive effect of alkaline drinking water on hyperuricemia in mice |
| YU Shali*, LIN Chen, JIANG Zhitao, ZHU Chao, ZHAO Xinyuan
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| *Department of Environmental Hygiene, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China |
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Abstract Objective To observe the preventive effect of alkaline drinking water on hyperuricemia in mice. Methods Sixty male SPF Kunming mice were randomly divided into six groups: pH 7.3, pH 8.0, pH 9.3 intervention groups, in which the mice were given water with pH values of 7.3±0.5, 8.0±0.5 and 9.3±0.6, respectively; the control group, model group and positive drug group ( with 2 g/L allopurinol ) were given double distilled water. Except for the control group, the mice in each group were given yeast by gavage ( 1.5 g/mL ) for 13 days. On the 14th day, the mice were injected with 300 mg/kg potassium oxyzinate by intraperitoneal injection, and then fasted for 1 day. On the 16th day, serum uric acid, creatinine and urea nitrogen were detected, and renal tissues were stained to observe the morphology. The expression levels of neutrophil gelatinase-associated lipocalin ( NGAL ), tissue inhibitor of metalloproteinase 1
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Received: 04 September 2022
Revised: 15 March 2021
Published: 10 August 2021
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[1] AKKASILPA S,AVIHINGSANON Y,HANVIVADHANAKUL P,et al.Clinical manifestations of patients with hyperuricemia[J]. J Med Assoc Thai,2004,87(Suppl.2):S41-S44.
[2] 康俏玲,方卫莲. 2型糖尿病合并高尿酸血症患者血黏度及下肢血管流量研究[J]. 预防医学, 2020,32(2):175-177.
[3] 李少峰,陈燕,董陆玲,等. 张家口市体检人群高尿酸血症患病现况及影响因素分析[J]. 预防医学,2018,30(3):236-239.
[4] GUASCH-FEERÉ M,BULLÓ M,BABIO N,et al.Mediterranean diet and risk of hyperuricemia in elderly participants at high cardiovascular risk[J]. J Gerontol A Biol Sci Med Sci,2013,68(10):1263-1270.
[5] YU K H,CHEN D Y,CHEN J H,et al.Management of gout and hyperuricemia:multidisciplinary consensus in Taiwan[J]. Int J Rheum Dis,2018,21(4):772-787.
[6] 孙珊珊,曲连悦,杜荣,等. 高尿酸血症药物预防研究进展[J]. 中国临床药理学与预防学,2019,24(5):589-594.
[7] DAY R O,KANNANGARA D R W,STOCKER S L,et al. Allopurinol:insights from studies of dose-response relationships[J]. Expert Opin Drug Metab Toxicol,2017,13(4):449-462.
[8] KOJIMA S,KOJIMA S,HIFUMI A,et al.Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension - a randomized crossover study (terao study)[J]. Int J Cardiol,2016,224:437-439.
[9] WASANA H M S,PERERA G D R K,GUNAWARDENA P D S,et al. WHO water quality standards vs synergic effect(s) of fluoride, heavy metals and hardness in drinking water on kidney tissues[J]. Sci Rep,2017,7:42516.
[10] KOUFMAN J A,JOHNSTON N.Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease[J]. Ann Otol Rhinol Laryngol,2012,121(7):431-434.
[11] NAI G A,GOLGHETTO J J,ESTRELLA M P S,et al. pH dependence of cadmium-contaminated drinking water on the development of cardiovascular injury in wistar rats[J]. Biol Trace Elem Res,2015,165(1):81-85.
[12] DAHL C,SØGAARD A J,TELL G S,et al. Is the quality of drinking water a risk factor for self-reported forearm fractures? Cohort of Norway[J]. Osteoporos Int,2013,24(2):541-551.
[13] 李媛媛,周海燕,吴绿英,等. 大鼠高尿酸血症模型的建立与研究[J]. 中国实验动物学报,2019,27(6):747-752.
[14] MUEANGKHIAO P,SIVIROJ P,SAPBAMRER R,et al.Biological variation in kidney injury and kidney function biomarkers among farmers in Lamphun province,Thailand[J]. Environ Sci Pollut Res Int,2020,27(11):12386-12394.
[15] 毛山山. NGAL-NGALR在肾小球肾炎中的表达及其机制的实验研究[D]. 上海:复旦大学,2011. |
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