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| Research progress on kidney injury induced by PM2.5 exposure |
| ZHAO Jiangang, ZHENG Jiaqi
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| Health Monitoring Section, Daishan County Center for Disease Control and Prevention, Daishan, Zhejiang 316200, China |
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Abstract Exposure to atmospheric PM2.5 is closely related to the morbidity and mortality of kidney diseases such as chronic kidney disease, membranous nephropathy and kidney cancer. Acute and chronic PM2.5 exposure lead to the damage of glomerular filtration and kidney tissue of mice. PM2.5 induces cellular oxidative stress, inflammatory response, endoplasmic reticulum stress, renin angiotensin system and bradykinin system activation, so that causes renal blood vessel and tissue damage, decreases glomerular filtration rate and clearance capacity, and mediates the occurrence of kidney damage and diseases. This article reviews the studies into the impact of PM2.5 on kidney and its mechanism form 2016 to 2020, so as to provide the basis for the prevention and treatment of kidney injury induced by PM2.5.
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Received: 17 September 2020
Revised: 11 January 2021
Published: 12 May 2021
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