激素治疗干预对围绝经期女性乳腺病变的影响

doi:10.19485/j.cnki.issn2096-5087.2019.09.005

Preventive Medicine

2019, Vol. 31

Issue (9): 882-885 DOI: 10.19485/j.cnki.issn2096-5087.2019.09.005

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Menopausal hormone therapy on breast lesions in perimenopausal women

MA Lin^*, HUANG Jian, CHEN Lin-jie, LOU Xiang-ming, ZHOU Jian, XIA Jian-yu, LU Chen-lei, WU Hong-yan

ZHANG Zhi-fen^*Department of Gynecology,Hangzhou Women's Hospital,Hangzhou,Zhejiang 310008,China

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Abstract Objective To explore the correlation between menopausal hormone therapy（MHT）and breast lesions in perimenopausal women,and to provide evidence for safe use of MHT. Methods The 40-60 year-old women who visited Hangzhou Women's Hospital and met the diagnostic criteria for perimenopausal syndrome were recruited. The intervention group received MHT and was divided into three subgroups according to the MHT regimen：estrogen-progesterone cycle therapy（A）,estrogen-progesterone continuous therapy（B）,estrogen therapy（C）. The control group did not receive MHT. All the patients received regular mammography to quantify and evaluate breast lesions. The generalized estimating equation was used to analyze the changes of breast lesions between different groups. Results There were 80 cases in the intervention group,with 49 in group A,26 in group B,5 in group C,and 80 cases in the control group. After two years of follow-up,there was no statistically significant differences of time,group and interaction in breast density,volume of breast fibrous tissue and the volume of breast between three intervention groups and the control group（P>0.05）; there was no statistically significant differences of group and interaction in positive rate of calcification and breast mass between the intervention group and the control group（P>0.05）. Conclusion Receiving MHT intervention for two years did not increase the risk of breast lesions.

Key words： Peri-menopause Menopausal hormone therapy Breast density Breast calcification Breast fibrous tissue volume

Received: 27 April 2019 Revised: 09 July 2019 Published: 02 September 2019

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[1] 中华医学会妇产科学分会绝经学组.中国绝经管理与绝经激素治疗指南(2018)[J]. 协和医学杂志,2018,9(6):19-32.
[2] 胡颖敏,蓝坚华,王佩英,等. 女性围绝经期综合征危险因素分析[J]. 预防医学,2017,29(10):1051-1057.
[3] 中华医学会妇产科学分会绝经学组. 绝经相关激素补充治疗的规范诊疗流程[J]. 中华妇产科杂志,2013,48(2):155-158.
[4] THORLEY J.HRT for menopause:a delicate balance[J]. Lancet Diabetes Endocrinol,2016,4:25.
[5] HOLM J,HUMPHREYS K,LI J,et al.Risk factors and tumor characteristics of interval cancers by mammographic density[J]. J Clin Oncol,2015,33(9):1030-1037.
[6] DAYE D,KELLER B,CONANT E F,et al.Mammographic parenchymal patterns as an imaging marker of endogenous hormonal exposure:a preliminary study in a high-risk population[J]. Acad Radiol,2013,20(5):635-646.
[7] DAVEY D A.Menopausal hormone therapy:a better and safer future[J]. Climacteric,2018,21(5):454-461.
[8] SEIFERT-KLAUS V,KINGSWELLS E,HITCHCOCK C L,et al.Estrogen and progestogen use in peri- and postmenopausal women:March 2007 position statement of The North American Menopause Society[J]. Menopause,2008,15(1):203-206.
[9] PINES A.Hormone therapy and breast cancer:the press-release version of WHI study data[J]. Climacteric,2013,16(2):222-225.
[10] WOOLCOTT C G,CONROY S M,NAGATA C,et al.Methods for assessing and representing mammographic density:an analysis of 4 case-control studies[J]. Am J Epidemiol,2014,179(2):236-244.
[11] 张洁琼,张琴,孟莉. 激素替代治疗与乳腺癌发生风险概述[J].中国妇幼保健,2015,30(36):6669-6672.
[12] STERNS E E,ZEE B.Mammographie density changes in perimenopausal and postmenopausal women is effect of hormone replacement therapy predietable[J]. Breast Cancer Res Treat,2000,59(2):125-132.
[13] 张巧利,李芬,吕淑兰,等. 性激素补充治疗对妇女乳腺密度的影响[J].现代妇产科进展,2014,23(12):994-997.
[14] MCTIERNAN A,MARTIN CF,PECK JD,et al.Estrogen- plus-progestin use and mammographic density in postmenopausal women:Women's Health Initiative randomized trial[J]. J Natl Cancer Inst,2005,97(18):1366-1376.
[15] SENDAG F,COSAN-TEREK M,OZSENER S,et al.Mammographic density changes during different postmenopausal hormone replacement therapies[J]. Fertil Steril,2001,76(3):445-450.
[16] MARTIN L J,MINKINS S,BOYD N F.Hormone therapy,mammographic density,and breast cancer risk[J]. Maturities,2009, 64(1):20-26.
[17] KOTSOPOULSO J,GRONWALD J,KALAN B Y,et al.Hormone replacement therapy after oophorectomy and breast cancer risk among BRCAI mutation carriers[J]. JAMA Oncol,2018,4(8):1059-1065.
[18] STUTE P,WILDT L,NEULEN J.The impact of micronized progesterone on breast cancer risk:a systematic review[J]. Climacteric,2018,21(2):111-122.
[19] BRANDT K R,SCOTT C G,MA L,et al.Comparison of clinical and automated breast density measurements:implications for risk prediction and supplemental screening[J]. Radiology,2016,279(3):710-719.