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| Effects of moderate-intensity aerobic exercise and dexrazoxane on myocardial injury induced by epirubicin in rats |
| BIAN Lin-li, FANG Hong-ming, CHEN Feng
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| Cancer Center of Zhejiang Xiaoshan Hospital,Hangzhou,Zhejiang 311200,China |
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Abstract Objective To explore the effects of moderate-intensity aerobic exercise（MIAE）and dexrazoxane（DEX）on rats myocardial damage induced by epirubicin.Methods A total of 40 SD female rats were randomly divided into normal control group（n=8）and myocardial injury group（n=32）to establish the rats myocardial damage model-induced by epirubicin. After successful modeling,the myocardial injury group was randomly divided into four groups：model group,DEX group,moderate-intensity aerobic exercise（MIAE）group and dexrazoxane plus moderate-intensity aerobic exercise（DEX+MIAE）group,and each group was treated for six weeks. Catalase（CAT）,total superoxide dismutase（T-SOD）,malondialdehyde（MDA）and apoptotic myocardial cell index were measured and the ventricular tissue was also pathological examined.Results After six weeks intervention,the level of CAT in the DEX+MIAE group was lower than that in the normal control group,but was higher than that in the DEX group,the MIAE group and the model group（P<0.05）;the DEX+MIAE group was lower than the normal control group,but was higher than the DEX group,the MIAE group and the model group in the level of the T-SOD（P<0.05）;the DEX+MIAE group was lower than the DEX group,the MIAE group and the model group（P<0.05）,but there was no significant difference compared with the normal control group in the level of the MDA（P>0.05）. The myocardial cell pathology score and the apoptotic index in the DEX+MIAE group was lower than those in the model group（P<0.01）,but there was no significant difference compared with the normal control group （P>0.01）. The degree of myocardial cell damage in the DEX+MIAE group was the lightest when observed by light microscope.Conclusion MIAE can improve the activity of CAT and T-SOD,reduce the level of MDA and the production of oxygen free radicals,also protect the cardiomyocytes. MIAE can improve the therapeutic effect of DEX.
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Received: 04 June 2018
Revised: 01 August 2018
Published: 06 November 2018
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