|
|
|
| The diagnostic value of salivary cortisol level for sleep disorders |
| XU Hui, ZHANG Ying-min, SHEN Zhi-qiang
|
| Zhejiang Qingchun Hospital,Hangzhou,Zhejiang 310016,China |
|
|
|
|
Abstract Objective To evaluate the diagnostic value of salivary cortisol for sleep disorders.Methods A total of 571 normal adults in Hangzhou were included,the concentration of saliva was determined by chemiluminescence immunoassay. The sleep quality was investigated by the Pittsburgh Sleep Quality Index（PSQI）scale. The relationship between salivary cortisol concentration and the diagnostic value of salivary cortisol derection for sleep disorders were analyzed.Results A total of 571 people were investigated and 267 cases of sleep disorders were found,accounting for 46.76%. Logistic regression analysis showed that salivary cortisol concentration was associated with sleep disorders（OR=1.870,95%CI：1.691-2.068）,male（OR= 0.628,95%CI：0.401-0.983）had a lower risk of sleep disorders than female. The ROC curve analysis showed that the salivary cortisol concentration of 6.55 nmol/L（male）and 7.40 nmol/L（female）were the best positive critical points for the screening test,with the corresponding AUC being 0.873（95%CI：0.839-0.911）and 0.885 （95%CI：0.841-0.929）,sensitivity being 78.5% and 68.3%,and specificity being 84.0% and 87.8%.Conclusion There was a positive correlation between salivary cortisol concentration and sleep disorders;saliva cortisol test can be auxiliary diagnosis of sleep disorders. It was recommended that the positive critical point of male and female diagnosis were 6.55 and 7.40 nmol/L,respectively.
|
|
Received: 07 June 2018
Revised: 16 August 2018
Published: 06 November 2018
|
|
|
|
|
|
[1] 宋. 西安市成年人情绪状态和睡眠质量的调查研究[D]. 西安：西安体育学院,2014：4-5.
[2] 刘宇,卞鑫,王加红.老年高血压患者睡眠干预效果评价[J]. 预防医学,2018,30（8）： 776-779.
[3] 徐春燕,李唯,潘超兰,等.大学生睡眠质量与饮食的关系研究[J]. 预防医学,2017,29（2）：142-145.
[4] BUXTON O M,PAVLOVA M,REID E W,et al. Sleep restruction for 1 week reduces insulin sensitivity in healthy men[J]. Diabetes Care,2010,59（9）：2126-2133.
[5] JUNG C,HO J T,TORPY D J,et al. A longitudinal study of plasma and urinary cortisol in pregnancy and postpartum[J].Journal of Clinical Endocrinology and Metabolism,2011,96（5）：1533-1540.
[6] 刘泰,湛剑飞. 中西医结合睡眠障碍诊疗学[M]. 北京：中国中医药出版社,2011：243-247.
[7] 秦海波,裴倩萍,吴斌,等. 音乐放松缓解作业人员应激情绪的研究[J]. 航天医学与医学工程,2017,30（3）：176-179.
[8] 刘贤臣,唐茂拜,胡蕾,等. 匹兹堡睡眠质量指数的信度和效度研究[J]. 中华精神科杂志,1996,29（2）：103-107.
[9] HUNG H C,YANG Y C,et al. The association between self- reported sleep quality and overweight in a Chinese population[J].Obesity,2013,21（3）：486-492.
[10] BOUDEBESSE C,GEOFFROY P A,HENRY C,et al. Links between sleep and body mass index in bipolar disorders： an exploratory study[J]. European Psychiatry,2015,30（1）： 89- 93.
[11] MORAES W,POYARES D,ZALEMAN I,et al. Association between body mass index and sleep duration assessed by objective methods in a representative sample of the adult population[J].Sleep Medicine,2013,14（4）：312-318.
[12] 段海平,刘玲耀,孙纯鸽,等. 青岛市城阳街道社区老年人体检结果分析[J]. 中国初级卫生保健,2015,29（10）：32-33.
[13] 杨佳琳,宋红涛,张理义,等. 睡眠剥夺对健康青年人心理健康和血清皮质醇影响及相关性研究[J]. 中华保健医学杂志,2015,17（6）：456-459.
[14] 祝筱姬,赵超,王敏,等. 战斗机飞行员飞行训练前后血皮质醇和睾酮的对比研究[J]. 实用医药杂志,2011,28（10）：865-867.
[15] 陈偶英,杨玉佩,钟捷,等. 神经科ICU护士工作应激对心理、睡眠及血清皮质醇的影响[J]. 护理研究,2015,29（9）：3096-3099.
[16] BEKO G,VARGA I,GLAZ E,et al. Cutoff values of mid-night salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods[J]. Clinica Chimica Acta,2010,41（5）：364-367.
[17] 吕丹菊. 护士职业倦怠与唾液皮质醇水平相关性的研究[D]. 锦州：辽宁医学院,2012：1-22.
[18] 毛嘉容. 神经内科护士睡眠障碍影响因素分析及对策[J]. 按摩与康复医学,2012,7（3）：155-156.
[19] 唐菊英,郑鹏杰,黎锋,等. 唾液皮质醇参考区间的建立及其临床意义评价[J]. 国际检验医学杂志,2013,34（20）：2678- 2681.
[20] 姚剑婷,许红峰,吴梦如. 唾液皮质醇分泌节律影响因素研究进展[J]. 新疆中医药,2017,35（1）：78-80. |
|
|
|
