|
|
|
| The immune effects of hepatitis B on children boosted with hepatitis A and B combined vaccine |
| LIU Can-lei, YAO Jun, SHI Hai-yun, SHANG Jian-bin, CHEN Dan, YIN Yin-xiang, LUO Ping
|
| The Center for Disease Control and Prevention of Yuhuan City, Taizhou, Zhejiang, 317600, China |
|
|
|
|
Abstract Objective To observe the concentration of the anti-HBs of children boosted with hepatitis A and B combined vaccine for 3 dosages, and to provide the basis for the implementation of hepatitis B booster immunization. Methods In September 2009 in Yuhuan by employing the cluster sampling method, 123 children, ranging from 6 to 9 years old,who had completed the basic immunization by 0-1-6 procedure without hepatitis B vaccine boosted and without anti-HBs were selected. In the year of 2011（after 1 year of inoculation）and 2015（5 years after inoculation）,the venous blood samples were collected to determine the concentration of anti-HBs. Results Boosted with hepatitis A and B combined vaccine for 3 times, the anti-HBs of 102 subjects was tested in the next year, of which the anti-HBs of 82 subjects was detected again in the later 5 years. The results suggested that the positive rates of antibody enhanced were 92.16% after 1 year and 78.05% after 5 years, respectively. The average concentration of anti-HBs of these 82 subjects was 2.95 mIU/mL before inoculation, 141.76 mIU/mL one year later and 72.13 mIU/mL 5 years later and there was statistically significant difference among them（P<0.05）. The difference was not statistically significant between subjects with different years of birth（P>0.05）. Moreover,the interaction was existed between the year of blood detection and year of birth （P<0.05）. Conclusion To children aged 6-9 years old whose anti-HBs were negative after the primary immunization of hepatitis B, booster immunization with 3 dosages of hepatitis A and B combined vaccine shows good immune effect against hepatitis B virus.
|
|
Received: 01 March 2017
Revised: 01 August 2017
Published: 06 November 2017
|
|
|
|
|
|
[1] 王宇. 全国人群乙型病毒性肝炎血清流行病学调查报告[M].北京：人民卫生出版社,2011：7-17.
[2] 崔富强. 中国人群乙型病毒性肝炎血清流行病学调查——乙型肝炎疫苗接种降低乙型肝炎病毒感染率[J]. 中国疫苗和免疫,2010,16（4）：341,353.
[3] 曹家穗,林云,何奔,等. 乙肝疫苗免疫失败影响因素分析[J]. 浙江预防医学,2009,21（12）：16,23.
[4] 李翠芳,刘幼平,黄贵彪,等. 新生儿重组乙型肝炎疫苗（酵母）初次免疫的血清学效果及低/无应答者再免疫血清学效果评价[J]. 中国疫苗和免疫,2013,19（3）：255- 259,284.
[5] 董晓莲,王学才,陈颖峰,等. 重组乙肝疫苗免疫持久性观察[J]. 浙江预防医学,2014,26（6）：548-551.
[6] 刘灿磊,姚军,陈永弟,等. 抗-HBs阴性儿童不同乙肝疫苗加强免疫效果观察[J]. 浙江预防医学,2015,27（1）：52-54.
[7] 蒋征刚,陈永弟,陈恩富,等. 基因工程乙型病毒性肝炎疫苗基础免疫5~11年后抗体阴性儿童加强免疫效果分析[J]. 疾病监测,2011,26（9）：679-681.
[8] 王永林,林桂伟,李笑琴. 儿童不同剂量乙肝疫苗加强免疫效果分析[J]. 中国学校卫生,2013,34（7）：887-890.
[9] 彭松青,崔伟红,冯国跃,等. 学龄儿童10 μg汉逊酵母重组乙肝疫苗加强免疫的效果及安全性评价[J]. 上海预防医学,2015,27（3）：116-118,124.
[10] 陈永弟,梁晓峰,姚军,等. 5岁以上儿童5 μg重组乙型肝炎疫苗（酵母）加强免疫效果评价[J]. 中国预防医学杂志,2012,13（2）：84-87.
[11] 梁剑,汤妍,刘研,等. 甲型肝炎灭活疫苗或甲型乙型肝炎联合疫苗加强免疫的免疫原性和安全性研究[J]. 华南预防医学,2012,38（4）：51-53.
[12] 姜梅,李波,彭松青,等. 健康幼儿甲型肝炎灭活疫苗及甲乙型肝炎联合灭活疫苗再免疫血清学效果及安全性研究[J]. 中国疫苗和免疫,2013,19（4）：312-318.
[13] 刘灿磊,姚军,施海云,等. 甲型乙型肝炎联合疫苗免疫后的甲肝免疫效果观察[J]. 浙江预防医学,2014,26（12）：1189-1192.
[14] 石义全,衣学梅,李娜,等. 龙口市健康儿童甲乙型肝炎联合疫苗加强免疫效果评价[J]. 预防医学论坛,2013,19（3）：181-183.
[15] 姜梅,李波,彭松青,等. 健康幼儿甲型肝炎灭活疫苗及甲乙型肝炎联合灭活疫苗再免疫血清学效果及安全性研究[J]. 中国疫苗和免疫,2013,19（4）：312-318.
[16] 王亚龙,陈文宇,徐文国,等. 甲、乙型肝炎联合疫苗在儿童中0、6月程序接种的安全性和免疫原性研究[J]. 中华预防医学杂志,2010,44（2）：154-156.
[17] WHO.Position paper on hepatitis B vaccine[S].2009-10-02.
[18] 刘中芹,王晓琼,张国庆,等. 乙肝疫苗免疫5年后抗-HBs衰减儿童免疫记忆观察[J]. 中华疾病控制杂志,2016,20（3）：315-316,322.
[19] 刘魁,李红芬,李陆美,等. 儿童不同剂次乙肝疫苗加强免疫效果分析[J]. 浙江预防医学,2016,28（5）：508-509.
[20] 黎健,任宏,徐爱强,等. 新生儿5微克重组乙型肝炎疫苗（酿酒酵母）无应答者不同剂次和剂量再免疫血清学效果研究[J]. 中国疫苗和免疫,2014,20（1）：31-35. |
|
|
|
