|
|
|
| A study on teratogenic effects of Chimonanthus salicifolius S. Y. Hu extract on SD rats |
| ZHENG Yun-yan, YAN jun, ZHU Zhou-jing, CAI De-lei, MENG Zhen, FU Jian-yun
|
| Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang,310051,China |
|
|
|
|
Abstract Objective To study maternal toxicity,embryotoxicity and teratogenecity of Chimonanthus salicifolius S. Y. Hu in SD rats.Methods A total of 64 successfully mated female SD rats were randomly divided in to 4 groups （16 per group）,in which 3 experimental groups were daily treated with 3.75,7.5 and 15.0 g/kg. bw test substance by lavage from 7th to 16th day during gestation respectively. Body weight and general conditions of the pregnant rats were recorded during the study. On the 20th day in pregnancy,the rats were anatomized and examined grossly,the fetuses were removed and counted,weight,length,visceral and skeletal changes were then examined. Results There was no significant difference in the conception rate,total weight gain during the pregnancy and the number of living, dead and resorbed fetuses between each dosage groups and the control group（P>0.05）. The number of the rib, sternum, the fifth sternum punctated and the parietal bone which were ossified defectively all showed no difference among the four groups（P>0.05）. Conclusion Chimonanthus salicifolius S. Y. Hu extract had no obvious maternal toxicity,embryotoxicity and teratogenecity in SD rats under this experiment condition.
|
|
Received: 13 October 2016
Revised: 15 December 2016
Published: 25 October 2017
|
|
|
|
|
|
[1] 张若蕙,沈湘林.蜡梅科的分类及地理分布与演化[J].北京林业大学学报,1999（2）：7-11.
[2] 李晓宇,何明.山腊梅叶镇痛、镇咳、祛痰作用的实验研究[J].中国中医药科技,1997,4（6）：366.
[3] 李萍,何明.山腊梅感冒茶抑菌抗炎解热作用的实验研究[J].中国中医药科技,1996,3（1）：19-20.
[4] 刁军成,伍学洲,丁舸.山蜡梅叶消毒抑菌的实验研究[J].江西中医药,2002,33（6）：35.
[5] 温慧萍,雷伟敏,吴宇锋.柳叶蜡梅茎叶水提物的“消导止泻”研究[J].中国现代中药,2013,15（11）：943-946.
[6] 中华人民共和国卫生部.食品安全性毒理学评价程序：GB 15193.1—2003[S].2003：89-94.
[7] 刘丽,蒋志红,褚婕.中药蜡梅花对正常小鼠免疫系统作用的研究[J].天津药学,2000,1（2）：29.
[8] 杨林波,江伟华,巴东娇,等.柳叶蜡梅灌肠剂对慢性盆腔炎大鼠子宫病理形态学的影响[J].中国中医药科技,2012,19（4）：344-345.
[9] 潘心禾,史小娟,张新凤,等.柳叶蜡梅化学成分及其抗氧化活性研究[J].中国实验方剂学杂志,2012,18（1）：99-101.
[10] 史小娟, 潘心禾, 张新凤, 等.柳叶蜡梅叶挥发性成分的提取及GC-MS分析[J]. 中国实验方剂学杂志, 2011, 17（9）： 129-132.
[11] 欧阳婷, 麦曦, 夏红英, 等.柳叶蜡梅叶挥发油化学成分GC-MS分析[J]. 南昌大学学报（理科版）, 2010, 34（1）： 78.
[12] 宋燕华,吴惠岭,夏勇,等.柳叶蜡梅对大鼠的亚慢性毒性研究[J]. 浙江预防医学,2013,25（10）：8-12.
[13] 王心如.毒理学基础[M].4版.北京：人民卫生出版社,2006：159-165. |
| [1] |
. [J]. Preventive Medicine, 2021, 33(12): 1290-1294. |
|
|
|
|
