Abstract：Objective To explore the influence of 30 day feeding test of health food containing caffeine on the physiological state of SD rat. Methods SD rats were randomly divided into five groups according weight :three health food containing caffeine(1.64, 3.28, 6.57 g/kg),one health food containing reduced caffeine(6.48 g/kg) and the control group. Haematological and biochemical parameters were measured at the end of experiment, and main organ tissue analysis was also performed. Results Weight at the end of 4 week, weight after absolute diet, total weight increased, and total food consumption and food consumption at the end of 4 week in 6.57 g/kg groups of male rats were decreased compared with the control group (P<0.05). Conclusion In comparison with 6.48 g/kg group, all those changes may be caused by overhigh caffeine in 6.48 g/kg group.
傅剑云, 陈苘, 张世鑫, 严峻, 郑云燕, 来婷, 夏勇. 含咖啡因保健食品30天喂养实验受试物处理与评价[J]. 预防医学, 2016, 28(7): 649-653,657.
FU Jian-yun, CHEN Qing, ZHANG Shi-xin, YAN Jun, ZHENG Yun-yan, LAI Ting, XIA Yong. A study on the influence of 30 day feeding test of healthfood containing caffeine on the physiological state of SD rat. Preventive Medicine, 2016, 28(7): 649-653,657.
[1]陈尧,周宏灏.咖啡因体内代谢及其应用的研究进展[J].生理科学进展,2010,41(4):256-260. [2]袁帅,毛方圆,刘洪利.咖啡因预防和治疗阿尔茨海默病的研究进展[J].山东医药,2012,52(9):90-92. [3]马莉,曹平安,陈阳,等.咖啡因在肿瘤防治中的研究进展[J].中华临床医师杂志:电子版,2013,7(20):9272-9274. [4]潘晓靓,刘冬琳,孟巍,等.咖啡因暴露对小鼠胚胎发育的影响[J].武汉大学学报:医学版,2008,29(2):165-168. [5]周书,黄晶,鲍冲,等.咖啡因致胎儿宫内发育迟缓机制的研究进展[J].中国药理学与毒理学杂志,2010,24(1):77-80. [6]中华人民共和国卫生部.保健食品检验与评价技术规范[Z].2003:169. [7]易超然,卫中庆.咖啡因的药理作用和应用[J].医学研究生学报,2005,18(3):270-272. [8]CHEN L W,WU Y,NEELAKANTAN N, et al.Maternal caffeine intake during pregnacy is associated with risk of low birth weight:a systematic review and dose-response meta-analysis [J].BMC Medicine,2014(12):174. [9]HITOMI O,YOSHIHIRO M, KEIKO T, et al.Materal total caffeine intake,mainly from Japanese and Chinese tea,during pregnancy was associated with risk of preterm birth :the Osaka maternal and child health study[J].Nutrition Research,2015,35(4):309-316. [10]GREENWOOD D C,THATCHER N J,YE J,et al.Caffeine intake during pregnancy and adverse birth outcomes:a systematic review and dose-response meta-analysis[J].Eur J Epidemiol,2014,29(10):725-734. [11]BRENT R L ,CHRISTIAN M S , DIENER R M.Evaluation of the reproductive and developmental risk of caffeine[J].Birth Defects Research,2011,92(2):152-187.DOI:10.1002/bdrb.20288. [12]CHRISTIAN M S,BRENT R L.Teratogen update:evaluation of the reproductive and developmental risks of caffeine[J].Teratology,2001,64(1):51-78.
