Effects of arsenic exposure during pregnancy on maternal and neonatal health: a review
WANG Xing1, TONG Juan1,2,3, LIANG Chunmei1,2,3, TAO Fangbiao1,2,3
1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; 2. Ministry of Education Key Laboratory of Population Health Across Life Cycle, Hefei, Anhui 230032, China; 3. Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui 230032, China
Abstract：Arsenic is a toxic metalloid, which may enter the human body through a variety of routes, including drinking water, food, and air. Previous studies have shown that arsenic exposure during pregnancy may cause pregnancy complications and adverse pregnancy outcomes, and maternal arsenic levels correlate with neonatal neurodevelopment and adult health. However, the negative impact of arsenic exposure during pregnancy on maternal and child health has not been widely accepted because of inconsistent study conclusions and unclear mechanisms. Based on international and national studies pertaining to the effect of arsenic exposure during pregnancy on maternal and child health during the period between 2007 and 2022, this review describes the influencing factors and biomarkers of arsenic exposure during pregnancy, associations of arsenic exposure during pregnancy with pregnancy complications and adverse pregnancy outcomes and impact of arsenic exposure during pregnancy on neonatal neurodevelopment, and discusses the mechanisms underlying negative health effects caused by arsenic exposure during pregnancy, so as to provide the evidence for assessing the hazards of arsenic exposure during pregnancy and formulating the control strategy.
汪兴, 童娟, 梁春梅, 陶芳标. 孕期砷暴露对母婴健康影响的研究进展[J]. 预防医学, 2023, 35(7): 591-595.
WANG Xing, TONG Juan, LIANG Chunmei, TAO Fangbiao. Effects of arsenic exposure during pregnancy on maternal and neonatal health: a review. Preventive Medicine, 2023, 35(7): 591-595.
[1] RAJU N J.Arsenic in the geo-environment:a review of sources,geochemical processes,toxicity and removal technologies[J/OL].Environ Res,2022,203[2023-05-17].https://doi.org/10.1016/j.envres.2021.111782. [2] WANG Y,ZHANG L,TENG Y,et al.Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose[J].J Environ Sci(China),2018,69:5-11. [3] BJØRKLUND G,TIPPAIROTE T,RAHAMAN M S,et al.Developmental toxicity of arsenic:a drift from the classical dose-response relationship[J].Arch Toxicol,2020,94(1):67-75. [4] MOCHIZUKI H.Arsenic neurotoxicity in humans[J/OL].Int J Mol Sci,2019,20(14)[2023-05-17].https://pubmed.ncbi.nlm.nih.gov/31336801/.DOI:10.3390/ijms20143418. [5] 张晶晶,魏淑慧,牛静萍,等.孕妇及胎儿体内镍、钴、铜、砷和硒暴露水平及影响因素探讨[J].环境卫生学杂志,2012,2(5):199-203,207. [6] BOZACK A K,SAXENA R,GAMBLE M V.Nutritional influences on one-carbon metabolism:effects on arsenic methylation and toxicity[J].Annu Rev Nutr,2018,38(1):401-429. [7] KILE M L,CARDENAS A,RODRIGUES E,et al.Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort[J].Epidemiology,2016,27(2):173-181. [8] BASSIL M,DAOU F,HASSAN H,et al.Lead,cadmium and arsenic in human milk and their socio-demographic and lifestyle determinants in Lebanon[J].Chemosphere,2018,191:911-921. [9] 余淑苑,季佳佳,刘宁,等.产妇和新生儿体内重金属水平及其影响因素分析[J].环境与健康杂志,2016,33(12):1073-1076. [10] 罗亚翠,张海君,郝伟.慢性砷中毒标志物及其形态分析[J].职业与健康,2019,35(8):1051-1054,1058. [11] KAJANTIE E,OSMOND C,ERIKSSON J G.Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring:the Helsinki birth cohort study[J].Am J Obstet Gynecol,2017,216(3):1-7. [12] WANG H,WENDER-OZEGOWSKA E,GARNE E,et al.Insulin analogues use in pregnancy among women with pregestational diabetes mellitus and risk of congenital anomaly:a retrospective population-based cohort study[J].BMJ Open,2018,8(2)[2023-05-17].https://pubmed.ncbi.nlm.nih.gov/29478010/.DOI:10.1136/bmjopen-2016-014972. [13] XIA X,LIANG C,SHENG J,et al.Association between serum arsenic levels and gestational diabetes mellitus:a population-based birth cohort study[J].Environ Pollut,2018,235:850-856. [14] ETTINGER A S,ZOTA A R,AMARASIRIWARDENA C J,et al.Maternal arsenic exposure and impaired glucose tolerance during pregnancy[J].Environ Health Perspect,2009,117(7):1059-1064. [15] FARZAN S F,GOSSAI A,CHEN Y,et al.Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study[J].Environ Health,2016,15(1)[2023-05-17].https://doi.org/10.1186/s12940-016-0194-0. [16] BONAVENTURA M M,BOURGUIGNON N S,BIZZOZZERO M,et al.Arsenite in drinking water produces glucose intolerance in pregnant rats and their female offspring[J].Food Chem Toxicol,2017,100:207-216. [17] 冯兰兰,梁春梅,黄锟,等.孕期和脐带血清砷水平及其与妊娠期高血压疾病关系[J].中国公共卫生,2019,35(5):542-545. [18] FARZAN S F,CHEN Y,WU F,et al.Blood pressure changes in relation to arsenic exposure in a U.S. pregnancy cohort[J].Environ Health Perspect,2015,123(10):999-1006. [19] WANG X,WU Y,SUN X,et al.Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women[J/OL].Ecotox Environ Safe,2021,222[2023-05-17].https://doi.org/10.1016/j.ecoenv.2021.112527. [20] WAGHE P,SARATH T S,GUPTA P,et al.Arsenic causes aortic dysfunction and systemic hypertension in rats:augmentation of angiotensin II signaling[J].Chem-Biol Interact,2015,237:104-114. [21] GOMEZ-LOPEZ N,GALAZ J,MILLER D,et al.The immunobiology of preterm labor and birth:intra-amniotic inflammation or breakdown of maternal-fetal homeostasis[J].Reproduction,2022,164(2):11-45. [22] VAHTER M E.Interactions between arsenic-induced toxicity and nutrition in early life[J].J Nutr,2007,137(12):2798-2804. [23] RAHMAN M L,KILE M L,RODRIGUES E G,et al.Prenatal arsenic exposure,child marriage,and pregnancy weight gain:associations with preterm birth in Bangladesh[J].Environ Int,2018,112:23-32. [24] VAN-DER-BOM T,ZOMER A C,ZWINDERMAN A H,et al.The changing epidemiology of congenital heart disease[J].Nat Rev Cardiol,2011,8(1):50-60. [25] RICHTER F,KLOSTER S,WODSCHOW K,et al.Maternal exposure to arsenic in drinking water and risk of congenital heart disease in the offspring[J/OL].Environ Int,2022,160[2023-05-17].https://doi.org/10.1016/j.envint.2021.107051. [26] JIN X,TIAN X,LIU Z,et al.Maternal exposure to arsenic and cadmium and the risk of congenital heart defects in offspring[J].Reprod Toxicol,2016,59:109-116. [27] LI D,LU C,WANG J,et al.Developmental mechanisms of arsenite toxicity in zebrafish(Danio rerio)embryos[J].Aquat Toxicol,2009,91(3):229-237. [28] XU F X,CHEN X,ZHANG H,et al.Association between gestational arsenic exposure and intrauterine growth restriction:the role of folate content[J].Environ Sci Pollut Res Int,2022,29(59):89652-89661. [29] SHIH Y H,SCANNELL-BRYAN M,ARGOS M.Association between prenatal arsenic exposure,birth outcomes,and pregnancy complications:an observational study within the national children's study cohort[J/OL].Environ Res,2020,183[2023-05-17].https://doi.org/10.1016/j.envres.2020.109182. [30] 丁秀丽,张亚萍,牛婷婷,等.脐带血重金属水平与胎儿生长发育情况的典型相关分析[J].环境与职业医学,2020,37(4):368-373. [31] KIPPLER M,WAGATSUMA Y,RAHMAN A,et al.Environmental exposure to arsenic and cadmium during pregnancy and fetal size:a longitudinal study in rural Bangladesh[J].Reprod Toxicol,2012,34(4):504-511. [32] 万君,柯红,王磊,等.低含量含砷水暴露对子代鼠生长和发育的影响[J].中国现代医学杂志,2019,29(4):9-13. [33] RAHMAN A,VAHTER M,EKSTRÖM E C,et al.Arsenic exposure in pregnancy increases the risk of lower respiratory tract infection and diarrhea during infancy in Bangladesh[J].Environ Health Perspect,2011,119(5):719-724. [34] SIGNES-PASTOR A J,MARTINEZ-CAMBLOR P,BAKER E,et al.Prenatal exposure to arsenic and lung function in children from the New Hampshire birth cohort study[J/OL].Environ Int,2021,155[2023-05-17].https://doi.org/10.1016/j.envint.2021.106673. [35] NAVAS-ACIEN A,SPRATLEN M J,ABUAWAD A,et al.Early-life arsenic exposure,nutritional status,and adult diabetes risk[J/OL].Curr Diab Rep,2019,19(12)[2023-05-17].https://doi.org/10.1007/s11892-019-1272-9. [36] ZHANG X,MEI D,LI Y,et al.Arsenic exposure via drinking water during pregnancy and lactation induces autism-like behaviors in male offspring mice[J/OL].Chemosphere,2022,290[2023-05-17].https://doi.org/10.1016/j.chemosphere.2021.133338. [37] FLORA S J.Arsenic-induced oxidative stress and its reversibility[J].Free Radic Biol Med,2011,51(2):257-281. [38] WEBER D,STUETZ W,BERNHARD W,et al.Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome[J].Eur J Clin Nutr,2014,68(2):215-222. [39] CHEN L,HEIKKINEN L,WANG C,et al.Trends in the development of miRNA bioinformatics tools[J].Brief Bioinform,2019,20(5):1836-1852. [40] RAHMAN M L,LIANG L,VALERI L,et al.Regulation of birthweight by placenta-derived miRNAs:evidence from an arsenic-exposed birth cohort in Bangladesh[J].Epigenetics,2018,13(6):573-590. [41] FU H Y,SHEN J Z,WU Y,et al.Arsenic trioxide inhibits DNA methyltransferase and restores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematologic malignant cells[J].Oncol Rep,2010,24(2):335-343. [42] TAM L M,PRICE N E,WANG Y.Molecular mechanisms of arsenic-induced disruption of DNA repair[J].Chem Res Toxicol,2020,33(3):709-726. [43] BROBERG K,AHMED S,ENGSTRÖM K,et al.Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood,particularly in boys[J].J Dev Orig Health Dis,2014,5(4):288-298.
