Abstract：On May 30 2022, Changsha Center for Disease Control and Prevention received a report of multiple cases of fever from a kindergarten. A field epidemiology investigation, laboratory testing, and control and prevention work were immediately conducted. A total of 76 cases were reported, and all were students, with an attack rate of 9.93%. The onset of illness was peaked between May 18 and June 8. The main clinical symptoms were fever, cough and sore throat, and all the cases were mild. There were 39 cases tested positive for human adenovirus (HAdV) nucleic acid or antigen, and 7 nucleic acid positive specimens were identified as HAdV-7 through virus isolation, culture and genotyping. The field epidemiology investigation and laboratory testing results concluded that it was a clustered outbreak caused by HAdV-7 infection. The main reason for the spread of the outbreak might be that the kindergarten failed to report it in time. High student density, poor classroom ventilation, lax morning and afternoon inspections, non-standard daily disinfection, and the prevalence of HAdV outbreaks in the community were also associated. Kindergartens should improve its infectious disease prevention and control mechanism, strictly follow the reporting regulations, implement the three early measures, standardize disinfection work, and enhance daily ventilation to avoid similar outbreaks in the future.
[1] 罗立梅,王晶,代春梅,等.学龄前呼吸道感染患儿8种呼吸道病原体的流行病学特征[J].中国热带医学,2019,19(12):1188-1190. [2] SCOTT M K,CHOMMANARD C,LU X Y,et al.Human adenovirus associated with severe respiratory infection,Oregon,USA,2013-2014[J].Emerg Infect Dis,2016,22(6):1044-1051. [3] 谌芳,赖源,覃亚斌,等.2016—2018年53 851例急性呼吸道感染儿童七项病毒检测结果分析[J].实用预防医学,2020,27(2):187-190. [4] WO Y,LU Q B,HUANG D D,et al.Epidemical features of HAdV-3 and HAdV-7 in pediatric pneumonia in Chongqing,China[J].Arch Virol,2015,160(3):633-638. [5] 陈伟,秦珑,王盛书,等.某学校一起呼吸道腺病毒7型暴发疫情调查与处置[J].军事医学,2017,41(12):994-997. [6] 人腺病毒呼吸道感染预防控制技术指南编写审定专家组.人腺病毒呼吸道感染预防控制技术指南(2019年版)[J].中华预防医学杂志,2019,53(11):1088-1093. [7] 中华人民共和国国家卫生健康委员会国家中医药管理局.儿童腺病毒肺炎诊疗规范(2019年版)[J].中华临床感染病杂志,2019,12(3):161-166. [8] 王亮,秦剑秋,尹刘江,等.人腺病毒7型流行病学及检测方法研究进展[J].中国卫生检验杂志,2022,32(19):2427-2430. [9] 陈晓飞,刘琪琦,周伟,等.人腺病毒及其分型方法研究进展[J].生物技术通讯,2017,28(5):700-703. [10] 王瑞欢,陈丽丽,马学军,等.人腺病毒分子生物学分型检测方法的研究进展[J].实用预防医学,2021,28(3):382-385. [11] 谢家敏,武婕.人腺病毒感染的流行病学研究进展[J].预防医学,2023,35(1):32-35,40. [12] 丁晨曦,艾乐乐,韩一芳,等.某部一起呼吸道腺病毒暴发疫情的流行病学分析[J].解放军预防医学杂志,2019,37(3):7-8,11. [13] WILLIAMS B G,GOUWS E,BOSCHI-PINTO C,et al.Estimates of world-wide distribution of child deaths from acute respiratory infections[J].Lancet Infect Dis,2002,2(1):25-32.
