Death of HIV/AIDS cases within 1 year in Jingzhou City from 1996 to 2021
LIN Maowen1, LIU Rui1, ZHANG Fan1, LI Shuchao1, LIU Jianzhao1, DOU Zhihui2, SUN Chun3
1. Department of AIDS/STD Control and Prevention, Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei 434000, China; 2. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; 3. Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei 434000, China
Abstract:Objective To investigate the characteristics of dead HIV/AIDS cases within 1 year after confirmatory testing in Jingzhou City, Hubei Province from 1996 to 2021, so as to provide the evidence for facilitating early identification and treatment of AIDS. Methods The basic and follow-up data of HIV/AIDS cases were retrieved from the HIV/AIDS Comprehensive Response Information System of Chinese Disease Prevention and Control Information System, and mortality density and its trend were evaluated within 1 year after confirmatory testing. The factors affecting death within 1 year after confirmatory testing were identified using a Cox proportional hazards model, and the demographics, detection, treatment and cause of death were analyzed among dead HIV/AIDS cases within 1 year after confirmatory testing. Results A total of 3 304 HIV/AIDS cases were included, with 508 deaths within 1 year after confirmatory testing. The overall mortality density was 17.43 per 100 person-years, and the mortality density appeared a tendency towards a reduction from 1996 to 2021 (χ2trend=21.053, P<0.001). Of all dead HIV/AIDS cases within 1 year after confirmatory testing, 77.76% were men, 67.72% at ages of 45 years and older, 83.86% with transmission by heterosexual contact, 83.66% identified in medical institutions, 62.20% without antiretroviral therapy, and 47.83% without detection of CD4+T cell count. Mortality that was not associated with AIDS was the predominant cause of death among dead HIV/AIDS cases within 1 year after confirmatory testing (58.86%). Age of 30 years and older (HR: 1.781-4.644, 95%CI: 1.073-7.784), identification in medical institutions (HR=2.130, 95%CI: 1.306-4.474), initial CD4+T cell count of <200 cells/μL (HR: 2.649-12.879, 95%CI: 1.669-19.189), no antiretroviral therapy (HR=7.945, 95%CI: 5.743-10.993) and initiation of antiretroviral therapy 4 to 12 months after confirmatory testing (HR=1.636, 95%CI: 1.005-2.662) resulted in a higher risk of mortality within 1 year after confirmatory testing. Conclusions The mortality density appeared a tendency towards a reduction among cases within 1 year after confirmatory testing in Jingzhou City from 1996 to 2021. Mortality within 1 year after confirmatory testing was associated with advanced age, heterosexual contact transmission, identification in medical institutions, low CD4+T cell counts, and delay or absence of antiretroviral therapy.
蔺茂文, 刘锐, 张凡, 李舒超, 刘建昭, 豆智慧, 孙春. 1996—2021年荆州市HIV/AIDS病例1年死亡分析[J]. 预防医学, 2023, 35(5): 396-400.
LIN Maowen, LIU Rui, ZHANG Fan, LI Shuchao, LIU Jianzhao, DOU Zhihui, SUN Chun. Death of HIV/AIDS cases within 1 year in Jingzhou City from 1996 to 2021. Preventive Medicine, 2023, 35(5): 396-400.
[1] 沈银忠,李太生.从我国艾滋病诊疗指南的变迁看艾滋病防治工作的进展与成效[J/CD].新发传染病电子杂志,2022,7(4):1-5. [2] 王斌,龚德光,朱洁群.鄞州区艾滋病抗病毒治疗患者生存率及影响因素分析[J].预防医学,2020,32(4):346-350. [3] 蔡畅,汤后林,李东民,等.我国艾滋病患者的死亡趋势及其相关危险因素分析[J].中华流行病学杂志,2021,42(1):121-125. [4] 叶振淼,金茜,王大勇,等.1985—2016年温州市HIV感染者和病人死亡情况分析[J].实用预防医学,2018,25(1):46-50. [5] 张金瑞,陈清峰,汤后林,等.黑龙江省佳木斯市2010—2020年HIV/AIDS确证后死亡密度特征分析[J].中华流行病学杂志,2022,43(12):1920-1924. [6] 张薇,彭国平,汤恒,等.2004—2013年湖北省HIV感染者/AIDS病人死亡情况分析[J].热带医学杂志,2016,16(1):102-105. [7] 李艳霞,王小平.我国艾滋病病毒感染者就医歧视化解研究[J].医学与法学,2016,8(6):48-51. [8] 叶振淼,金茜,王大勇,等.1985—2016年温州市HIV感染者和病人死亡情况分析[J].实用预防医学,2018,25(1):46-50. [9] 顾艳红,周春娟,徐里强.2000—2020年常熟市艾滋病死亡病例分析[J].江苏预防医学,2022,33(3):306-307. [10] 张薇,彭国平,汤恒,等.2004—2013年湖北省HIV感染者/AIDS病人死亡情况分析[J].热带医学杂志,2016,16(1):102-105. [11] 金怡晨,蔡畅,蓝光华,等.2019年广西两区县报告死亡HIV/AIDS患者的死因调查[J].中国艾滋病性病,2022,28(4):420-424. [12] 蔺茂文,张凡,李舒超,等.1996—2021年荆州市HIV/AIDS流行特征分析[J].预防医学情报杂志,2023,39(1):13-23. [13] 巩仪凡,金艳涛,李鹏宇,等.河南省某地区HIV/AIDS死因特点分析[J].中国皮肤性病学杂志,2021,35(10):1141-1145. [14] CHEN F F,CAI C,WANG S,et al.Trends in suicide mortality among people with HIV after diagnosis during 2012-18:a retrospective,national cohort study in China[J].Lancet HIV,2022,9(2):102-111. [15] 陈修远,张昱勤,张静,等.2016—2018年广东省艾滋病抗病毒治疗者首年死亡率分析[J].中华疾病控制杂志,2022,26(6):645-650. [16] BABIKER AG,PETO T,PORTER K,et al.Age as a determinant of survival in HIV infection[J/OL].J Clin Epidemiol,2001,54 [2023-04-11] .https://doi.org/10.1016/S0895-4356(01)00456-5. [17] 孙群露,周宗磊,詹志强,等.宝安区50岁及以上HIV/AIDS病例生存状况分析[J].预防医学,2021,33(2):170-173. [18] GARRIGA C,GARCIA-DE-OLALLA P,MIRO J M,et al.Mortality,Causes of death and associated factors relate to a large HIV population-based cohort[J/OL].PLoS One,2015,10(12)[2023-04-11] .https://doi.org/10.1371/journal.pone.0145701. [19] 金霞,熊燃,毛宇嵘.2008—2013年我国医疗机构检测发现艾滋病病例情况分析[J].中华流行病学杂志,2015,36(4):323-326. [20] RUFFIEUX Y,DHOKOTERA T,MUCHENGETI M,et al.Cancer risk in adolescents and young adults living with HIV in South Africa:a nationwide cohort study[J].Lancet HIV,2021,8(10):614-622. [21] 周涛,李月飞,白雪,等.2005—2019年伊犁州抗病毒治疗吸毒人群HIV/AIDS病例生存分析[J].预防医学,2021,33(1):25-30. [22] ZHANG F J,DOU Z H,MA Y,et al.Five-year outcomes of the China national free antiretroviral treatment program[J].Ann Intern Med,2009,151(4):1-42. [23] 胡晓松,吕华坤,王慎玉,等.文山州HIV/AIDS抗病毒治疗病例艾滋病羞辱和歧视的影响因素分析[J].预防医学,2021,33(3):226-230.