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预防医学  2022, Vol. 34 Issue (11): 1096-1100,1104    DOI: 10.19485/j.cnki.issn2096-5087.2022.11.004
  艾滋病防治专题 本期目录 | 过刊浏览 | 高级检索 |
杭州市新确证在校学生HIV/AIDS分子传播网络分析
许珂, 陈珺芳, 张兴亮, 罗文杰, 吴嗣圣, 黄思超
杭州市疾病预防控制中心艾滋病性病防制所,浙江 杭州 310021
HIV-1 molecular transmission network among school students with newly confirmed HIV/AIDS in Hangzhou City
XU Ke, CHEN Junfang, ZHANG Xingliang, LUO Wenjie, WU Sisheng, HUANG Sichao
Department of HIV/AIDS and STDS Control and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang 310021, China
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摘要 目的 分析杭州市2020—2021年新确证在校学生艾滋病病毒感染者和艾滋病患者(HIV/AIDS)的HIV分子传播网络特征,为学校艾滋病防控提供依据。方法 选择杭州市2020—2021年新确证的在校学生HIV/AIDS为研究对象,通过中国疾病预防控制信息系统艾滋病综合防治信息系统收集人口学和流行病学调查资料。采集血样,采用反转录PCR和巢式PCR测定HIV-1 pol区基因,采用序列多重比对确定基因亚型;比较杭州市同期新确证HIV/AIDS病例基因序列,使用MEGA 11软件分析基因距离,使用Cytoscape 3.9.1软件绘制分子传播网络图,分析网络内成簇病例的特征。结果 杭州市2020—2021年新确证在校学生HIV/AIDS 99例,其中男性98例,占98.98%;男男性行为传播94例,占94.94%。87例获得HIV-1 pol基因序列,包括4种基因亚型,其中CRF07_BC 49例,占56.32%;CRF01_AE 27例,占31.03%;CRF55_01B 6例,占6.90%;CRF67_01B 5例,占5.75%。50例学生HIV/AIDS与男男性行为人群(MSM)形成30个分子簇,簇内学生病例数2~16例,其中27个分子簇与非学生病例相关,且成簇的学生病例均为男男性行为传播。感染途径、学校所在地、非学生病例现住址是学生病例成簇的影响因素,学校所在的范围是簇内HIV/AIDS病例重要的活动区域。结论 杭州市2020—2021年新确证在校学生HIV/AIDS的HIV-1亚型以CRF07_BC和CRF01_AE为主,病例传播与非学生病例关系密切,传播途径以男男性行为为主。需加强对MSM人群的干预,遏制艾滋病从社会面向校内传播。
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许珂
陈珺芳
张兴亮
罗文杰
吴嗣圣
黄思超
关键词 艾滋病学生分子传播网络男男性行为人群    
AbstractObjective To investigate the HIV-1 molecular transmission network among school students with newly confirmed HIV/AIDS in Hangzhou City from 2020 to 2021, so as to provide insights into AIDS control in school. Methods School students with newly confirmed HIV/AIDS in Hangzhou City from 2020 to 2021 were sampled, and participants' demographics and epidemiological survey data were retrieved from the HIV/AIDS Control Information System of Chinese Disease Prevention and Control Information System. The HIV-1 pol gene was amplified in participants' blood samples using reverse transcription (RT) and nested PCR assays, and the HIV subtypes were characterized through multiple sequence alignments. The gene sequences were aligned among newly confirmed HIV/AIDS patients in Hangzhou City during the same study period. The genetic distance was estimated using the software MEGA 11, and the molecular transmission network was created using the software Cytoscape 3.9.1 to analyze the characteristics of clustered cases in the network. Results A total of 99 school students were newly confirmed with HIV/AIDS in Hangzhou City from 2020 to 2021, including 98 men (98.98%), and 94 men who had sex with men (94.94%). The HIV-1 pol gene sequence was successfully amplified from 87 cases, and four HIV-1 subtypes were characterized, including CRF07_BC (49 cases, 56.32%), CRF01_AE (27 cases, 31.03%), CRF55_01B (6 cases, 6.90%) and CRF67_01B (5 cases, 5.75%). There were 30 molecular clusters in 50 MSM, with 2 to 16 cases in each cluster, and 27 molecular clusters associated with non-student cases, and clustered cases were all MSM. Infection route, location of schools and current address of non-student cases were identified as factors affecting case clustering, and the residence of schools was an important area of activity among clustered HIV/AIDS cases. Conclusions CRF07_BC and CRF01_AE were predominant HIV-1 subtypes among school students with newly confirmed HIV/AIDS in Hangzhou City from 2020 to 2021, and the transmission of HIV/AIDS strongly correlated with non-student cases, with men-men sexual behaviors as the predominant transmission route. The interventions for of MSM is recommended to be reinforced to block the transmission of HIV/AIDS from community to schools.
Key wordsAIDS    school student    molecular transmission network    man who have sex with man
收稿日期: 2022-07-04      修回日期: 2022-09-15      出版日期: 2022-11-10
中图分类号:  R512.91  
基金资助:浙江省基础公益研究计划(LGF20H260002); 杭州市农业与社会发展科研一般项目(20201203B203); 杭州市医学重点学科(感染性疾病学)
作者简介: 许珂,本科,副主任技师,主要从事艾滋病防制工作
引用本文:   
许珂, 陈珺芳, 张兴亮, 罗文杰, 吴嗣圣, 黄思超. 杭州市新确证在校学生HIV/AIDS分子传播网络分析[J]. 预防医学, 2022, 34(11): 1096-1100,1104.
XU Ke, CHEN Junfang, ZHANG Xingliang, LUO Wenjie, WU Sisheng, HUANG Sichao. HIV-1 molecular transmission network among school students with newly confirmed HIV/AIDS in Hangzhou City. Preventive Medicine, 2022, 34(11): 1096-1100,1104.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2022.11.004      或      http://www.zjyfyxzz.com/CN/Y2022/V34/I11/1096
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